| 02h30 | ABC | Chapecoense AF |
| 02h00 | Universidad Catolica | Mushuc Runa |
| 23h00 | Guairena | Luqueno | |||
| 01h30 | Libertad | Sportivo Ameliano |
| 01h00 | Independiente | Sarmiento |
| FT | Barracas Central | 0-0 (0-0) | Rosario Central |
| FT | Cork City | 1-2 (1-1) | Dundalk | ||
| FT | Derry City | 0-0 (0-0) | Bohemian FC | ||
| FT | Drogheda United | 2-1 (1-1) | St. Patrick's Athletic | ||
| FT | Shelbourne | 1-1 (1-1) | Sligo Rovers | ||
| FT | Shamrock Rovers | 4-0 (3-0) | UCD |
| FT | Lebanon | 3-1 (0-0) | Vanuatu | ||
| FT | India | 2-0 (2-0) | Mongolia | ||
| FT | Luxembourg | 0-1 (0-0) | Malta |
| FT | Viborg | 0-1 (0-0) | FC Midtjylland |
| FT | Shakhtyor Soligorsk | 3-0 (2-0) | Isloch | ||
| FT | Dinamo Minsk | 4-1 (2-0) | Dynamo Brest |
| FT | Hammarby | 2-1 (1-0) | Brommapojkarna |
| FT | Beroe | 1-0 (1-0) | Sportist Svoge |
| FT | FS Metta/LU | 0-6 (0-2) | RFS | ||
| FT | Valmiera FC | 1-0 (0-0) | Riga FC | ||
| FT | FK Liepaja | 2-1 (2-1) | SK Super Nova |
| FT | Henan FC | 2-2 (0-1) | Zhejiang Professional | ||
| FT | Dalian Professional FC | 2-2 (2-0) | Beijing Guoan | ||
| FT | Meizhou Hakka | 2-3 (1-1) | Fujian Smart Hero | ||
| FT | Shanghai East Asia | 2-1 (0-1) | Nantong Zhiyun FC | ||
| FT | Wuhan Three Towns | 1-1 (1-1) | Shandong Taishan |
| FT | Santa Fe | 2-0 (1-0) | Universitario de Deportes |
| FT | Universidad Cesar Vallejo | 3-2 (2-1) | Magallanes |
| FT | Olimpia | 3-0 (1-0) | Atletico Nacional |
| FT | Flamengo | 2-1 (1-0) | Racing Club |
| FT | San Lorenzo | 0-0 (0-0) | Palestino |
