| FT | Gimhae FC 2008 | 1-4 (1-0) | Ansan Greeners |
| FT | Incheon United | 1-2 (0-0) | FC Seoul | ||
| FT | Ulsan HD FC | 3-1 (2-0) | Gangwon FC |
| FT | Machida Zelvia | 2-1 (1-0) | JEF United Chiba | ||
| FT | Yokohama F.Marinos | 3-2 (1-0) | Tokyo Verdy | ||
| FT | Urawa Red Diamonds | 2-3 (2-1) | Kashima Antlers |
| FT | Melbourne Victory | 1-1 (1-1) | Adelaide United | ||
| FT | Auckland FC | 3-0 (1-0) | Melbourne City FC |
| FT | Mazatlan FC | 1-0 (1-0) | Pachuca | ||
| FT | Queretaro FC | 2-2 (2-2) | Santos Laguna | ||
| FT | FC Juarez | 3-1 (2-1) | Atlas | ||
| FT | Tijuana | 1-1 (1-1) | Club Universidad Nacional |
| FT | Millonarios | 5-1 (4-0) | Deportivo Pereira | ||
| FT | Once Caldas | 3-0 (2-0) | Chico FC |
| FT | Costa Rica F | 2-5 (0-3) | Brésil F |
| FT | Tecnico Universitario | 1-1 (0-1) | Orense |
| FT | Cobresal | 0-1 (0-1) | La Serena | ||
| FT | Union La Calera | 3-0 (1-0) | Audax Italiano |
| FT | FAR Rabat | 3-0 (2-0) | CODM Meknes | ||
| FT | MAS Fes | 1-1 (0-0) | KACM |
| FT | MC El Bayadh | 0-0 (0-0) | USM Alger | ||
| FT | Paradou AC | 1-2 (0-1) | MC Oran | ||
| FT | JS Saoura | 1-0 (0-0) | ES Ben Aknoun |
| FT | FC Porto | 3-1 (1-0) | Arouca | ||
| FT | Sporting CP | 3-0 (2-0) | Estoril |
| FT | Derry City | 4-2 (0-1) | Waterford FC | ||
| FT | Drogheda United | 1-2 (1-0) | Shelbourne | ||
| FT | Galway United FC | 1-0 (1-0) | Sligo Rovers | ||
| FT | St. Patrick's Athletic | 4-0 (2-0) | Dundalk | ||
| FT | Bohemian FC | 3-2 (1-0) | Shamrock Rovers |
| FT | Monza | 2-0 (0-0) | Virtus Entella | ||
| FT | Sampdoria | 0-2 (0-1) | Bari |
| FT | Levante | 2-0 (0-0) | Deportivo Alaves |
| FT | Bristol City | 1-2 (1-1) | Watford |
| FT | Wolverhampton Wanderers | 2-0 (0-0) | Aston Villa |
| FT | Bala Town | 0-0 (0-0) | Llanelli |
| FT | Caernarfon | 3-0 (1-0) | Colwyn Bay |
| FT | Athlone Town | 2-2 (1-1) | Wexford FC | ||
| FT | Cobh Ramblers | 1-1 (1-0) | Finn Harps | ||
| FT | Cork City | 1-0 (1-0) | Bray Wanderers | ||
| FT | Kerry FC | 1-1 (0-0) | Longford Town | ||
| FT | UCD | 2-0 (2-0) | Treaty United |
| FT | Strasbourg | 1-1 (1-0) | Lens |
| FT | Standard Liege | 1-1 (1-1) | RAAL La Louviere |
| FT | Parma Calcio 1913 | 1-1 (0-0) | Cagliari |
| FT | Albacete | 1-1 (0-0) | Almeria |
| FT | Augsburg | 2-0 (0-0) | FC Koeln |
| FT | Cracovia | 2-3 (1-0) | Piast Gliwice | ||
| FT | Arka Gdynia | 2-2 (1-0) | Lechia Gdansk |
| FT | Debreceni VSC | 2-2 (0-0) | MTK Budapest |
| FT | Al Hazem | 3-1 (2-1) | Al-Ettifaq | ||
| FT | Al Ittihad | 1-0 (0-0) | Al Khaleej | ||
| FT | Al Shabab | 3-5 (2-3) | Al Hilal |
| FT | Clermont Foot | 2-1 (0-1) | Dunkerque | ||
| FT | Grenoble | 0-0 (0-0) | Boulogne | ||
| FT | Laval | 1-1 (1-0) | Nancy | ||
| FT | Montpellier | 0-0 (0-0) | Reims | ||
| FT | SC Bastia | 0-2 (0-2) | Annecy FC |
| FT | Gent U23 | 2-1 (0-1) | Patro Eisden | ||
| FT | Kortrijk | 3-1 (1-0) | FC Liege |
| FT | Telstar | 3-0 (1-0) | NAC Breda |
| FT | Zalgiris Vilnius | 4-1 (1-1) | FK Panevezys |
| FT | Hermannstadt | 3-1 (2-0) | Botosani | ||
| FT | Universitatea Cluj | 4-0 (2-0) | Otelul Galati |
| FT | Magesi FC | 0-2 (0-1) | Polokwane City | ||
| FT | Stellenbosch FC | 1-0 (1-0) | AmaZulu FC |
| FT | Dynamo Dresden | 3-1 (2-0) | Darmstadt | ||
| FT | Fortuna Duesseldorf | 2-1 (1-0) | VFL Bochum |
| FT | Istanbul Basaksehir | 2-0 (0-0) | Konyaspor | ||
| FT | Trabzonspor | 3-1 (1-1) | Fatih Karagumruk |
| FT | Dukla Praha | 0-2 (0-2) | Slavia Prague |
| FT | Slaven | 1-0 (0-0) | NK Istra 1961 |
| FT | Zenit St. Petersburg | 1-0 (0-0) | Baltika |
| FT | Independiente del Valle | 1-2 (1-1) | Inter Miami CF | ||
| FT | Rosenborg | 0-1 (0-1) | Vaalerenga | ||
| FT | Molde | 4-1 (2-0) | Aalesund | ||
| FT | Lillestroem | 0-0 (0-0) | Tromsoe |
| FT | Arda Kardzhali | 1-0 (0-0) | Spartak Varna | ||
| FT | Montana | 0-0 (0-0) | Botev Plovdiv | ||
| FT | Slavia Sofia | 0-2 (0-2) | CSKA 1948 |
| FT | FC Kapaz | 3-0 (3-0) | Sumqayit | ||
| FT | Araz PFK | 0-1 (0-0) | Zira |
| FT | Dynamo Kyiv | 4-0 (1-0) | Epitsentr Kamianets-Podilskyi | ||
| FT | Shakhtar Donetsk | 1-0 (0-0) | Veres Rivne |
| FT | Sanfrecce Hiroshima | 1-2 (1-0) | Kyoto Sanga FC | ||
| FT | Vissel Kobe | 2-1 (0-0) | Avispa Fukuoka |
| Pen. | *Tolima | 0-1(0-1) | Deportivo Tachira |
| FT | Philadelphia Union | 7-0 (3-0) | Defence Force |
