| FT | Tigres | 1-2 (1-0) | Pachuca | ||
| FT | Puebla | 0-4 (0-1) | CF America | ||
| FT | Atlas | 3-2 (1-2) | Atletico de San Luis | ||
| FT | Leon | 2-1 (2-1) | Santos Laguna | ||
| FT | Necaxa | 0-3 (0-0) | Toluca | ||
| FT | Cruz Azul | 2-1 (1-0) | CD Guadalajara | ||
| FT | Tijuana | 1-1 (1-0) | Mazatlan FC |
| FT | Shimizu S-Pulse | 1-0 (0-0) | Vissel Kobe | ||
| FT | Nagoya Grampus | 1-3 (0-0) | V-Varen Nagasaki | ||
| FT | Fagiano Okayama FC | 1-2 (1-1) | Gamba Osaka | ||
| FT | Kyoto Sanga FC | 2-0 (1-0) | Avispa Fukuoka |
| Pen. | *Tokyo Verdy | 2-2(2-2) | Machida Zelvia | ||
| FT | Yokohama F.Marinos | 0-2 (0-0) | Urawa Red Diamonds | ||
| FT | Kawasaki Frontale | 1-2 (1-2) | FC Tokyo | ||
| FT | Kashima Antlers | 2-0 (1-0) | Kashiwa Reysol | ||
| Pen. | *Mito Hollyhock | 1-1(1-1) | JEF United Chiba |
| FT | St. Louis City | 1-1 (0-0) | Charlotte FC | ||
| FT | FC Cincinnati | 2-0 (0-0) | Atlanta United | ||
| FT | DC United | 1-0 (1-0) | Philadelphia Union | ||
| FT | Orlando City | 1-2 (0-2) | Red Bull New York | ||
| FT | Vancouver Whitecaps | 1-0 (0-0) | Real Salt Lake | ||
| FT | Austin FC | 2-2 (1-1) | Minnesota United | ||
| FT | FC Dallas | 3-2 (2-1) | Toronto FC | ||
| FT | Houston Dynamo FC | 2-1 (0-1) | Chicago Fire FC | ||
| FT | Nashville SC | 4-1 (3-0) | New England Revolution | ||
| FT | Los Angeles FC | 3-0 (1-0) | Inter Miami CF | ||
| FT | Portland Timbers | 3-2 (2-2) | Columbus Crew | ||
| FT | San Diego FC | 5-0 (2-0) | CF Montreal | ||
| FT | San Jose Earthquakes | 3-0 (2-0) | Sporting Kansas City |
| FT | Deportivo Pereira | 2-2 (1-0) | Deportivo Pasto | ||
| FT | Once Caldas | 4-2 (1-1) | Fortaleza FC | ||
| FT | Bucaramanga | 0-0 (0-0) | Deportivo Cali | ||
| FT | Atletico Nacional | 3-0 (2-0) | Alianza FC | ||
| FT | Internacional de Bogota | 3-2 (0-0) | Millonarios |
| FT | Gimnasia Mendoza | 0-1 (0-1) | Gimnasia LP | ||
| FT | Rosario Central | 0-1 (0-1) | Talleres | ||
| FT | Club Atletico Platense | 1-0 (0-0) | Barracas Central | ||
| FT | Independiente Rivadavia | 3-2 (1-0) | Independiente | ||
| FT | Banfield | 3-0 (0-0) | Newell's Old Boys | ||
| FT | Deportivo Riestra | 0-0 (0-0) | Huracan | ||
| FT | Central Cordoba de Santiago | 0-0 (0-0) | Tigre |
| FT | Huachipato | 2-1 (0-1) | Palestino | ||
| FT | O'Higgins | 0-1 (0-0) | Colo Colo | ||
| FT | Universidad Catolica | 3-1 (1-1) | Coquimbo Unido |
| FT | KACM | 0-0 (0-0) | Difaa El Jadida | ||
| FT | Olympique Dcheira | 0-5 (0-3) | Wydad Casablanca | ||
| FT | Union Touarga Sport | 1-1 (0-0) | FAR Rabat |
| FT | Orense | 1-2 (1-2) | LDU de Quito | ||
| FT | Aucas | 1-1 (1-0) | Mushuc Runa | ||
| FT | Barcelona SC | 1-0 (0-0) | Tecnico Universitario |
| FT | Cerro Porteno | 0-1 (0-1) | Olimpia |
| FT | ES Ben Aknoun | 2-3 (0-0) | USM Khenchela | ||
| FT | ES Mostaganem | 2-2 (0-0) | JS Kabylie | ||
| FT | Olympique Akbou | 4-3 (1-2) | Paradou AC | ||
| FT | USM Alger | 1-2 (0-2) | JS Saoura |
| FT | Alverca | 1-1 (1-0) | Santa Clara | ||
| FT | Arouca | 3-0 (0-0) | Nacional | ||
| FT | Benfica | 3-0 (3-0) | AVS Futebol SAD | ||
| FT | Moreirense | 0-3 (0-0) | Sporting CP | ||
| FT | Braga | 3-2 (2-1) | Vitoria de Guimaraes |
| FT | Lens | 2-3 (1-0) | Monaco | ||
| FT | Toulouse | 1-1 (0-1) | Paris FC | ||
| FT | Paris St-Germain | 3-0 (2-0) | Metz |
| FT | Saint-Etienne | 0-2 (0-0) | Strasbourg (F) | ||
| FT | FC Fleury 91 (F) | 0-0 (0-0) | Dijon Foot | ||
| FT | Nantes | 2-2 (2-0) | Montpellier | ||
| FT | Marseille | 2-6 (0-2) | Lyon (F) |
| FT | Leganes | 1-1 (0-1) | Cultural Leonesa | ||
| FT | Deportivo La Coruna | 1-0 (1-0) | Eibar | ||
| FT | SD Huesca | 1-2 (0-1) | CD Mirandes | ||
| FT | Almeria | 2-1 (2-0) | Cordoba | ||
| FT | Las Palmas | 1-1 (1-0) | Castellon |
| FT | Real Sociedad | 3-3 (0-0) | Real Oviedo | ||
| FT | Real Betis | 1-1 (1-1) | Rayo Vallecano | ||
| FT | Osasuna | 2-1 (1-0) | Real Madrid | ||
| FT | Atletico Madrid | 4-2 (1-1) | Espanyol |
| FT | PSV Eindhoven | 3-1 (1-1) | SC Heerenveen | ||
| FT | NAC Breda | 1-0 (0-0) | FC Volendam | ||
| FT | Ajax Amsterdam | 1-1 (1-0) | NEC Nijmegen |
| FT | Aston Villa | 1-1 (0-1) | Leeds United | ||
| FT | Brentford | 0-2 (0-2) | Brighton & Hove Albion | ||
| FT | Chelsea | 1-1 (1-0) | Burnley | ||
| FT | West Ham United | 0-0 (0-0) | AFC Bournemouth | ||
| FT | Manchester City | 2-1 (2-1) | Newcastle United |
| FT | FCV Dender EH | 1-4 (1-2) | St.Truiden | ||
| FT | Club Brugge | 2-1 (0-0) | OH Leuven | ||
| FT | Union St.Gilloise | 2-1 (1-0) | Royal Antwerp |
| FT | Juventus | 0-2 (0-1) | Como | ||
| FT | Lecce | 0-2 (0-0) | Inter Milan | ||
| FT | Cagliari | 0-0 (0-0) | Lazio |
| FT | Servette | 1-1 (1-1) | Saint-Gall | ||
| FT | Grasshopper Zurich | 1-2 (0-1) | FC Zürich |
| FT | Longford Town | 1-2 (0-2) | Cobh Ramblers |
| FT | Darmstadt | 2-1 (1-1) | Fortuna Duesseldorf | ||
| FT | Elversberg | 3-1 (2-1) | Eintracht Braunschweig | ||
| FT | Karlsruher SC | 3-1 (1-0) | Holstein Kiel | ||
| FT | Schalke 04 | 5-3 (2-1) | Magdeburg |
| FT | Aberdeen | 2-3 (1-2) | Dundee FC | ||
| FT | Dundee United | 1-1 (0-0) | Kilmarnock | ||
| FT | Hearts | 1-0 (1-0) | Falkirk | ||
| FT | St. Mirren | 0-5 (0-2) | Motherwell |
| FT | Rakow Czestochowa | 1-0 (1-0) | Termalica Nieciecza | ||
| FT | Gornik Zabrze | 0-1 (0-0) | Pogon Szczecin | ||
| FT | Legia Warszawa | 2-1 (1-0) | Wisla Plock |
| FT | Al Hilal | 1-1 (1-0) | Al Ittihad | ||
| FT | Al Khaleej | 0-1 (0-0) | Neom SC | ||
| FT | Al Nassr FC | 4-0 (2-0) | Al Hazem |
| FT | Eupen | 1-1 (0-1) | Francs Borains | ||
| FT | K. Lierse SK | 1-3 (1-1) | Gent U23 | ||
| FT | KSC Lokeren | 2-3 (0-1) | Lommel |
| FT | Reims | 0-0 (0-0) | Amiens | ||
| FT | Troyes | 4-3 (2-2) | Pau | ||
| FT | St-Etienne | 2-1 (2-1) | Laval |
| FT | Calcio Padova | 1-1 (1-1) | Bari | ||
| FT | Mantova | 2-1 (0-1) | Sampdoria | ||
| FT | Palermo | 3-0 (2-0) | Sudtirol | ||
| FT | Venezia | 3-2 (2-1) | Pescara | ||
| FT | Virtus Entella | 1-3 (0-1) | Catanzaro | ||
| FT | Cesena | 2-3 (1-1) | Spezia | ||
| FT | Carrarese | 0-1 (0-0) | Monza |
| FT | CFR 1907 Cluj | 2-1 (0-0) | Petrolul Ploiesti | ||
| FT | Rapid Bucuresti | 2-1 (2-0) | Dinamo Bucarest |
| FT | Torreense | 1-0 (1-0) | Benfica B | ||
| FT | Maritimo | 1-0 (0-0) | Sporting CP B | ||
| FT | Oliveirense | 2-4 (0-1) | Uniao de Leiria |
| FT | Bangor | 1-3 (0-1) | Glenavon | ||
| FT | Cliftonville | 5-2 (2-1) | Crusaders | ||
| FT | Portadown | 1-0 (0-0) | Dungannon Swifts | ||
| FT | Linfield | 1-0 (0-0) | Glentoran |
| FT | Maccabi Tel Aviv | 3-2 (2-1) | FC Ashdod | ||
| FT | Maccabi Haifa | 0-1 (0-0) | Hapoel Petah Tikva | ||
| FT | Hapoel Jerusalem FC | 0-1 (0-0) | Hapoel Ironi Kiryat Shmona | ||
| FT | Bnei Sakhnin | 0-0 (0-0) | Hapoel Tel Aviv | ||
| FT | Ironi Tiberias | 2-1 (0-0) | Maccabi Bnei Raina |
| FT | AS Jeunesse Esch | 3-2 (0-1) | Racing FC Union Luxembourg |
| FT | FK Velez Mostar | 1-0 (0-0) | Zeljeznicar | ||
| FT | Rudar Prijedor | 0-0 (0-0) | Radnik Bijeljina | ||
| FT | FK Sarajevo | 3-0 (2-0) | Posusje |
| FT | Bayern Munich | 3-2 (2-0) | Eintracht Frankfurt | ||
| FT | FC Koeln | 2-2 (1-1) | Hoffenheim | ||
| FT | Union Berlin | 1-0 (1-0) | Bayer Leverkusen | ||
| FT | VFL Wolfsburg | 2-3 (1-0) | Augsburg | ||
| FT | RB Leipzig | 2-2 (2-0) | Borussia Dortmund |
| FT | Nyiregyhaza Spartacus FC | 2-2 (1-2) | Kisvarda | ||
| FT | Kazincbarcikai BSC | 0-2 (0-2) | Puskas FC Academy | ||
| FT | Ujpest | 2-1 (2-0) | Diosgyori VTK |
| FT | Eyupspor | 1-0 (0-0) | Genclerbirligi | ||
| FT | Alanyaspor | 1-2 (0-2) | Istanbul Basaksehir | ||
| FT | Konyaspor | 2-0 (0-0) | Galatasaray |
| FT | DAC 1904 Dunajska Streda | 3-2 (3-0) | Skalica | ||
| FT | Tatran Presov | 1-1 (0-1) | Komarno | ||
| FT | Trencin | 1-2 (0-0) | Zemplin Michalovce | ||
| FT | Spartak Trnava | 0-5 (0-2) | Zeleziarne Podbrezova |
| FT | Hradec Kralove | 0-0 (0-0) | FC Zlin | ||
| FT | Jablonec | 1-0 (0-0) | Karvina | ||
| FT | Slovacko | 2-0 (1-0) | Pardubice | ||
| FT | Slavia Prague | 1-0 (0-0) | Slovan Liberec |
| FT | Olimpija Ljubljana | 3-3 (0-1) | Koper | ||
| FT | Radomlje | 2-1 (1-0) | Primorje |
| FT | NK Istra 1961 | 0-2 (0-1) | HNK Gorica | ||
| FT | NK Lokomotiva | 3-1 (0-1) | Osijek |
| FT | Apollon Limassol | 1-0 (1-0) | Ethnikos Achnas | ||
| FT | Olympiakos Nicosia | 1-3 (1-0) | Akritas Chlorakas | ||
| FT | Pafos FC | 0-0 (0-0) | Anorthosis |
| FT | Altach | 2-1 (2-1) | Austria Wien | ||
| FT | Hartberg | 1-0 (0-0) | Grazer AK | ||
| FT | Rapid Vienne | 2-0 (0-0) | Wolfsberger AC |
| FT | Birkirkara | 0-3 (0-1) | Zabbar St. Patrick | ||
| FT | Tarxien Rainbows | 1-2 (0-0) | Naxxar Lions FC | ||
| FT | Valletta | 0-1 (0-0) | Sliema Wanderers |
| FT | Dobrudzha Dobrich | 1-0 (1-0) | Montana | ||
| FT | Lokomotiv Plovdiv | 1-1 (0-0) | Spartak Varna | ||
| FT | PFK CSKA Sofia | 1-0 (0-0) | Slavia Sofia |
| FT | PFC Sochi | 3-0 (2-0) | Aktobe | ||
| FT | Vaalerenga | 3-2 (1-1) | Tromsoe | ||
| FT | CSKA Moscow | 2-1 (2-0) | Lokomotiv Moscow | ||
| FT | Spartak Moscow | 5-2 (1-0) | FC Rostov | ||
| FT | PFC Sochi | 3-2 (2-0) | Bars Karakol | ||
| FT | Vaalerenga | 1-0 (1-0) | KFUM |
| FT | Asteras Tripolis | 1-2 (0-2) | Atromitos | ||
| FT | Olympiacos | 2-0 (1-0) | Panetolikos |
| FT | Hull City | 1-3 (1-1) | Queens Park Rangers | ||
| FT | Stoke City | 2-2 (1-0) | Leicester City | ||
| FT | Swansea City | 1-0 (1-0) | Bristol City | ||
| FT | West Bromwich Albion | 0-2 (0-2) | Coventry City | ||
| FT | Middlesbrough | 0-0 (0-0) | Oxford United | ||
| FT | Millwall | 1-3 (0-0) | Portsmouth | ||
| FT | Norwich City | 1-2 (0-2) | Birmingham City | ||
| FT | Southampton | 1-1 (0-0) | Charlton Athletic | ||
| FT | Watford | 2-0 (1-0) | Derby County | ||
| FT | Wrexham | 5-3 (2-2) | Ipswich Town |
| FT | FK Radnik Surdulica | 2-1 (0-1) | Napredak | ||
| FT | OFK Beograd | 0-0 (0-0) | Zeleznicar Pancevo | ||
| FT | Vojvodina | 0-3 (0-2) | Novi Pazar |
| FT | Briton Ferry | 2-1 (0-0) | Bala Town | ||
| FT | Flint Town United | 1-1 (0-0) | Cardiff Met University |
| FT | Barry Town | 1-0 (0-0) | Connah's Quay Nomads | ||
| FT | Colwyn Bay | 3-1 (1-0) | Penybont |
| FT | FC Fiorentino | 2-1 (0-0) | Juvenes/Dogana | ||
| FT | La Fiorita Montegiardino | 2-2 (1-1) | SP Libertas | ||
| FT | SS Pennarossa | 2-3 (0-1) | Folgore |
| FT | Epitsentr Kamianets-Podilskyi | 0-2 (0-1) | LNZ Cherkasy | ||
| FT | Metalist 1925 | 0-0 (0-0) | Kryvbas |
| FT | OB | 2-2 (1-0) | FC Koebenhavn |
| FT | Zalgiris Vilnius | 2-3 (1-1) | Dziugas Telsiai |
| FT | Malisheva | 0-0 (0-0) | Dukagjini |
| FT | Karvan FK | 0-2 (0-1) | Araz PFK |
| FT | Wellington Phoenix | 0-5 (0-4) | Auckland FC | ||
| FT | Sydney FC | 1-0 (0-0) | Brisbane Roar FC | ||
| FT | Melbourne City FC | 1-3 (1-1) | Melbourne Victory |
