| FT | Santa Fe | 1-2 (1-1) | Once Caldas |
| FT | Delfin | 0-0 (0-0) | Libertad |
| FT | Racing Club | 2-3 (1-2) | Union | ||
| FT | Gimnasia LP | 1-0 (0-0) | Atletico Tucuman | ||
| FT | Club Atletico Platense | 1-3 (0-1) | Godoy Cruz |
| FT | SD Huesca | 2-1 (1-1) | Eibar | ||
| FT | Leganes | 2-2 (2-0) | Deportivo La Coruna |
| FT | Csikszereda Miercurea Ciuc | 1-1 (0-1) | Otelul Galati | ||
| FT | FCV Farul Constanta | 2-1 (1-1) | Petrolul Ploiesti |
| FT | Zrinjski Mostar | 2-0 (1-0) | Radnik Bijeljina |
| FT | Llapi | 1-1 (0-0) | Drita |
| FT | Tijuana | 3-0 (1-0) | Necaxa |
| FT | Los Angeles FC | 1-2 (1-1) | San Diego FC |
| FT | Seattle Sounders FC | 3-0 (1-0) | Inter Miami CF |
