| FT | FC Juarez | 2-1 (0-1) | Santos Laguna | ||
| FT | Queretaro FC | 3-2 (1-1) | Atletico de San Luis | ||
| FT | Tijuana | 3-3 (1-0) | CD Guadalajara |
| FT | Llaneros FC | 2-1 (2-1) | Deportivo Pasto |
| FT | Palestino | 0-0 (0-0) | Colo Colo | ||
| FT | Deportes Limache | 2-2 (1-0) | O'Higgins |
| FT | Libertad | 3-2 (1-1) | Aucas |
| FT | Barracas Central | 1-1 (0-0) | Defensa y Justicia | ||
| FT | Tigre | 1-1 (0-0) | Independiente Rivadavia |
| FT | Nacional | 1-1 (1-0) | Atletico Tembetary |
| FT | Eibar | 3-0 (1-0) | Granada CF | ||
| FT | Castellon | 0-1 (0-1) | Real Valladolid | ||
| FT | Leganes | 1-1 (1-0) | Cadiz |
| FT | Real Betis | 1-0 (1-0) | Deportivo Alaves |
| FT | Chaves | 1-1 (1-0) | Felgueiras 1932 |
| FT | Posusje | 0-0 (0-0) | Rudar Prijedor |
| FT | Derby County | 1-1 (0-1) | Bristol City |
| FT | West Ham United | 1-5 (1-3) | Chelsea |
| FT | Bohemian FC | 3-0 (1-0) | Cork City | ||
| FT | Drogheda United | 0-1 (0-0) | St. Patrick's Athletic | ||
| FT | Galway United FC | 1-2 (1-1) | Derry City | ||
| FT | Waterford FC | 1-2 (1-0) | Sligo Rovers |
| FT | Bala Town | 1-0 (1-0) | Colwyn Bay | ||
| FT | Barry Town | 2-3 (1-1) | Penybont | ||
| FT | Flint Town United | 2-5 (2-2) | Caernarfon | ||
| FT | Haverfordwest | 2-2 (2-0) | Cardiff Met University | ||
| FT | Llanelli | 2-4 (2-2) | Briton Ferry | ||
| FT | TNS | 3-0 (2-0) | Connah's Quay Nomads |
| FT | Larne | 4-0 (2-0) | Portadown |
| FT | Paris St-Germain | 1-0 (0-0) | Angers |
| FT | Cobh Ramblers | 2-2 (1-1) | UCD | ||
| FT | Finn Harps | 2-1 (1-0) | Athlone Town | ||
| FT | Kerry FC | 1-0 (0-0) | Longford Town | ||
| FT | Treaty United | 0-7 (0-4) | Dundalk | ||
| FT | Wexford FC | 0-1 (0-1) | Bray Wanderers |
| FT | Pescara | 1-3 (1-1) | Cesena |
| FT | Fatih Karagumruk | 0-2 (0-1) | Goztepe |
| FT | Bayern Munich | 6-0 (3-0) | RB Leipzig |
| FT | UTA Arad | 1-1 (1-0) | FC Unirea Slobozia | ||
| FT | FC Metaloglobus Bucuresti | 1-2 (1-2) | Rapid Bucuresti |
| FT | Radomiak Radom | 1-1 (1-1) | Termalica Nieciecza | ||
| FT | Widzew Lodz | 1-2 (1-1) | Pogon Szczecin |
| FT | Domzale | 0-2 (0-0) | Aluminij |
| FT | Gent U23 | 1-1 (0-0) | Beerschot | ||
| FT | Patro Eisden | 2-1 (1-0) | Club Brugge NXT |
| FT | Sliema Wanderers | 0-1 (0-0) | Mosta |
| FT | Amiens | 0-1 (0-1) | Annecy FC | ||
| FT | Clermont Foot | 2-1 (0-0) | Grenoble | ||
| FT | Dunkerque | 1-3 (1-2) | Nancy | ||
| FT | Le Mans | 1-0 (0-0) | SC Bastia | ||
| FT | Rodez | 1-1 (1-0) | Laval |
| FT | Vukovar 91 | 2-2 (1-2) | HNK Gorica |
| FT | Puskas FC Academy | 1-3 (0-1) | Debreceni VSC |
| FT | Gomel | 2-3 (2-1) | BATE Borisov | ||
| FT | Maxline Vitebsk | 2-0 (1-0) | Naftan Novopolotsk |
| FT | PFC Lokomotiv Sofia 1929 | 0-0 (0-0) | Spartak Varna |
| Pen. | Kenya | 1-1(1-1) | Madagascar* | ||
| FT | Tanzania | 0-1 (0-0) | Maroc |
| FT | AEL Limassol | 2-0 (2-0) | Olympiakos Nicosia |
| FT | FC Orenburg | 2-2 (2-0) | FK Akhmat |
| FT | Javor | 0-0 (0-0) | Napredak |
| FT | KFUM | 2-2 (0-1) | Hamarkameratene |
| FT | Elversberg | 2-1 (1-0) | Kaiserslautern | ||
| FT | Preussen Muenster | 2-1 (2-0) | Nuernberg |
| FT | FCI Levadia | 1-3 (0-3) | Parnu JK Vaprus |
| FT | MC El Bayadh | 0-2 (0-1) | CS Constantine | ||
| FT | Olympique Akbou | 1-0 (0-0) | ES Mostaganem |
| FT | Riteriai | 0-2 (0-1) | Dziugas Telsiai |
| FT | Imisli FK | 0-0 (0-0) | FK Neftchi | ||
| FT | Qarabag FK | 0-1 (0-0) | Sumqayit |
| FT | VPS | 3-2 (1-2) | FC KTP |
| FT | ADO La Haye | 3-0 (1-0) | PEC Zwolle |
| FT | Kashiwa Reysol | 4-2 (0-2) | Urawa Red Diamonds |
| Pen. | *Lanus | 1-0(1-0) | Central Cordoba de Santiago |
| FT | Palmeiras | 0-0 (0-0) | Universitario de Deportes | ||
| Pen. | *River Plate | 1-1(1-1) | Libertad |
