| FT | Puebla | 0-2 (0-1) | Atletico de San Luis | ||
| FT | Necaxa | 0-1 (0-1) | Leon | ||
| FT | CD Guadalajara | 1-2 (0-1) | FC Juarez | ||
| FT | Cruz Azul | 3-2 (2-1) | Santos Laguna | ||
| FT | Pachuca | 0-2 (0-2) | Tijuana | ||
| FT | Tigres | 1-3 (1-1) | CF America | ||
| FT | Toluca | 1-1 (0-1) | Club Universidad Nacional |
| FT | CF Montreal | 1-1 (1-1) | DC United | ||
| FT | Charlotte FC | 1-0 (1-0) | Real Salt Lake | ||
| FT | Inter Miami CF | 3-1 (1-0) | LA Galaxy | ||
| FT | New England Revolution | 0-2 (0-0) | Los Angeles FC | ||
| FT | New York Red Bulls | 1-0 (0-0) | Philadelphia Union | ||
| FT | Toronto FC | 1-1 (0-1) | Columbus Crew | ||
| FT | Austin FC | 1-1 (0-1) | FC Dallas | ||
| FT | Minnesota United | 1-0 (0-0) | Seattle Sounders FC | ||
| FT | Colorado Rapids | 3-1 (1-1) | Atlanta United | ||
| FT | Chicago Fire FC | 3-2 (1-0) | St. Louis City | ||
| FT | Portland Timbers | 2-3 (1-3) | FC Cincinnati | ||
| FT | Orlando City | 3-1 (1-1) | Sporting Kansas City |
| FT | La Equidad | 2-1 (1-1) | Llaneros FC | ||
| FT | Aguilas Doradas | 2-0 (0-0) | Chico FC | ||
| FT | Atletico Nacional | 2-2 (1-2) | Fortaleza FC |
| FT | Ceara | 1-0 (1-0) | Red Bull Bragantino | ||
| FT | Fluminense | 2-1 (1-0) | Fortaleza | ||
| FT | Sport Recife | 2-2 (1-0) | Sao Paulo | ||
| FT | Vitoria | 2-2 (1-0) | Juventude | ||
| FT | Corinthians | 1-2 (1-2) | Bahia |
| FT | Delfin | 0-3 (0-2) | El Nacional | ||
| FT | Mushuc Runa | 1-0 (0-0) | Aucas | ||
| FT | Universidad Catolica | 1-1 (1-1) | Libertad | ||
| FT | Independiente del Valle | 2-1 (1-0) | Orense |
| FT | Racing Club | 1-2 (1-0) | Tigre | ||
| FT | Club Atletico Platense | 2-1 (2-1) | San Lorenzo | ||
| FT | Huracan | 1-0 (0-0) | Argentinos Juniors | ||
| FT | Rosario Central | 1-1 (1-0) | Deportivo Riestra | ||
| FT | Velez Sarsfield | 2-1 (1-0) | Independiente |
| FT | Union La Calera | 1-1 (1-0) | La Serena | ||
| FT | CD Nublense | 1-0 (1-0) | Palestino | ||
| FT | Colo Colo | 1-4 (1-3) | Universidad Catolica | ||
| FT | O'Higgins | 1-0 (1-0) | Cobresal |
| FT | Sportivo Ameliano | 0-1 (0-1) | Luqueno | ||
| FT | Guarani | 3-4 (2-2) | Cerro Porteno |
| FT | Tondela | 0-1 (0-0) | Famalicao | ||
| FT | Vitoria de Guimaraes | 3-2 (1-1) | Estoril | ||
| FT | Estrela da Amadora | 0-1 (0-0) | Benfica |
| FT | Racing Santander | 3-1 (2-1) | Castellon | ||
| FT | Malaga | 1-1 (0-0) | Eibar | ||
| FT | Granada CF | 1-3 (0-1) | Deportivo La Coruna |
| FT | Mallorca | 0-3 (0-2) | Barcelona | ||
| FT | Deportivo Alaves | 2-1 (1-0) | Levante | ||
| FT | Valencia | 1-1 (0-0) | Real Sociedad |
| FT | Venezia | 4-0 (2-0) | Mantova | ||
| FT | Como | 3-1 (3-1) | Sudtirol | ||
| Pen. | *Cagliari | 1-1(1-1) | Virtus Entella | ||
| Pen. | Cremonese | 0-0(0-0) | Palermo* |
| FT | Lens | 0-1 (0-1) | Lyon | ||
| FT | Monaco | 3-1 (1-0) | Le Havre | ||
| FT | Nice | 0-1 (0-0) | Toulouse |
| FT | Valletta | 0-0 (0-0) | Birkirkara | ||
| FT | Zabbar St. Patrick | 1-2 (1-2) | Sliema Wanderers |
| FT | FK Sarajevo | 2-1 (1-1) | Posusje |
| FT | Excelsior | 1-2 (1-2) | Feyenoord | ||
| FT | Heracles | 1-4 (1-1) | NEC Nijmegen | ||
| FT | FC Groningen | 2-1 (1-1) | SC Heerenveen |
| FT | NK Lokomotiva | 1-3 (1-0) | HNK Gorica | ||
| FT | Rijeka | 0-2 (0-2) | Dinamo Zagreb |
| FT | Roma | 2-2 (2-2) | Neom SC | ||
| FT | Lazio | 2-0 (0-0) | Atromitos | ||
| FT | Inter Milan | 2-0 (1-0) | Olympiacos | ||
| FT | Atalanta | 1-2 (0-0) | Juventus | ||
| FT | Bologna | 2-4 (1-0) | OFI Crete |
| FT | Zulte Waregem | 0-1 (0-0) | Club Brugge | ||
| FT | KV Mechelen | 1-1 (1-0) | La Gantoise | ||
| FT | Union St.Gilloise | 3-0 (1-0) | Standard Liege |
| FT | Kocaelispor | 0-1 (0-0) | Samsunspor | ||
| FT | Alanyaspor | 0-0 (0-0) | Çaykur Rizespor | ||
| FT | Goztepe | 0-0 (0-0) | Fenerbahce |
| FT | Romanshorn | 2-4 (0-0) | FC Altstatten | ||
| FT | Walenstadt | 0-13 (0-5) | Saint-Gall | ||
| FT | FC La Sarraz Eclepens | 1-4 (0-2) | FC Grand-Saconnex | ||
| AP | Lommiswil | AP 1-4 | Prishtina Bern | ||
| FT | Stade Payerne | 1-3 (0-0) | Yverdon | ||
| AP | Kriens | AP 2-3 | Wil | ||
| FT | Breitenbach | 0-5 (0-2) | Bosna Neuchatel | ||
| FT | CS Le Locle | 2-1 (1-1) | FC Saxon Sports | ||
| FT | Diaspora | 2-3 (1-1) | Xamax | ||
| FT | FC Morbio | 2-1 (1-0) | FC Gossau | ||
| Pen. | *FC Unterstrass | 4-4(2-2) | FC Klingnau | ||
| FT | FC Veyrier Sport | 0-2 (0-0) | FC Stade Lausanne-Ouchy | ||
| AP | Haerkingen | AP 2-3 | Schaffhausen | ||
| FT | Nebikon | 0-4 (0-1) | Bellinzona | ||
| FT | SV Schaffhausen | 0-5 (0-1) | Winterthur | ||
| AP | Signal FC Bernex-Confignon | AP 0-3 | Etoile Carouge | ||
| AP | Vernier | AP 0-1 | Echallens | ||
| Pen. | *Zug | 0-0(0-0) | Mendrisio FC | ||
| FT | Wohlen | 1-3 (1-1) | Aarau | ||
| FT | FC Bâle | 6-1 (4-0) | Biel/Bienne |
| FT | Petrolul Ploiesti | 1-1 (0-0) | Hermannstadt |
| FT | Ruzomberok | 0-1 (0-1) | Zemplin Michalovce | ||
| FT | Slovan Bratislava | 1-0 (1-0) | Skalica | ||
| FT | Zeleziarne Podbrezova | 2-1 (2-0) | Komarno | ||
| FT | Tatran Presov | 0-0 (0-0) | DAC 1904 Dunajska Streda |
| FT | VfB Stuttgart | 1-2 (0-1) | Bayern Munich |
| FT | Mura | 3-0 (1-0) | Domzale | ||
| FT | Maribor | 3-3 (0-1) | NK Bravo |
| FT | Diosgyori VTK | 2-2 (0-2) | Kazincbarcikai BSC | ||
| FT | Ferencvarosi TC | 1-2 (1-1) | Puskas FC Academy |
| FT | Spartak Varna | 1-3 (1-2) | Cherno More Varna | ||
| FT | Beroe | 1-2 (0-0) | Botev Plovdiv |
| FT | Motor Lublin | 0-0 (0-0) | Piast Gliwice | ||
| FT | GKS Katowice | 4-1 (2-1) | Arka Gdynia | ||
| FT | Lech Poznan | 1-1 (0-0) | Korona Kielce |
| FT | Kortrijk | 1-0 (0-0) | K. Lierse SK | ||
| FT | Beerschot | 1-1 (0-1) | Eupen | ||
| FT | Gent U23 | 0-1 (0-0) | Anderlecht Futures | ||
| FT | KSC Lokeren | 1-3 (0-2) | RWDM Brussels | ||
| FT | Lommel | 3-0 (1-0) | Olympic de Charleroi |
| FT | Annecy FC | 2-2 (2-1) | Dunkerque | ||
| FT | Reims | 1-0 (1-0) | Guingamp | ||
| FT | St-Etienne | 4-0 (1-0) | Rodez |
| FT | Dukla Praha | 2-0 (2-0) | Viktoria Plzen | ||
| FT | Mlada Boleslav | 3-2 (2-1) | Hradec Kralove | ||
| FT | Sigma Olomouc | 1-0 (0-0) | FC Zlin | ||
| FT | Slovacko | 2-1 (0-1) | Teplice | ||
| FT | Jablonec | 1-1 (1-0) | Slavia Prague |
| FT | Novi Pazar | 2-0 (1-0) | FK Radnik Surdulica | ||
| FT | Vojvodina | 2-2 (0-0) | Javor |
| FT | Grazer AK | 1-1 (0-1) | WSG Tirol | ||
| FT | Hartberg | 1-2 (0-1) | Red Bull Salzbourg | ||
| FT | Ried | 1-3 (1-3) | Sturm Graz |
| FT | Baltika | 1-1 (1-0) | Lokomotiv Moscow | ||
| FT | Spartak Moscow | 2-2 (2-1) | Zenit St. Petersburg | ||
| FT | FK Akhmat | 3-1 (1-0) | Krylya Sovetov Samara |
| FT | Burkina Faso | 1-2 (1-1) | Madagascar | ||
| FT | Central African Republic | 0-0 (0-0) | Tanzania |
| FT | BATE Borisov | 2-1 (1-0) | FK Molodechno | ||
| FT | Naftan Novopolotsk | 3-0 (1-0) | FK Vitebsk | ||
| FT | Torpedo Zhodino | 2-2 (1-1) | FK Slutsk |
| FT | Greenock Morton | 0-3 (0-2) | Aberdeen | ||
| FT | Partick Thistle | 2-0 (2-0) | Ayr United | ||
| AP | St. Johnstone | AP 0-1 | Motherwell | ||
| Pen. | *St. Mirren | 1-1(1-1) | Hearts | ||
| FT | Rangers | 4-2 (2-1) | Alloa Athletic |
| FT | Union Titus Petange | 0-2 (0-1) | US Hostert |
| FT | Aston Villa | 0-0 (0-0) | Newcastle United | ||
| FT | Brighton & Hove Albion | 1-1 (0-0) | Fulham | ||
| FT | Sunderland | 3-0 (0-0) | West Ham United | ||
| FT | Tottenham Hotspur | 3-0 (1-0) | Burnley | ||
| FT | Wolverhampton Wanderers | 0-4 (0-2) | Manchester City |
| FT | Barry Town | 1-1 (1-1) | Colwyn Bay | ||
| FT | Caernarfon | 6-1 (2-0) | Llanelli | ||
| FT | Penybont | 0-2 (0-1) | TNS |
| FT | Imisli FK | 0-1 (0-0) | Turan Tovuz | ||
| FT | FK Neftchi | 1-1 (1-1) | Shamakhi FK |
| AP | BFC Dynamo | AP 1-3 | VFL Bochum | ||
| AP | Pirmasens | AP 1-2 | Hamburger SV | ||
| FT | Bahlinger SC | 0-5 (0-2) | FC Heidenheim | ||
| Pen. | Eintracht Norderstedt | 0-0(0-0) | St. Pauli* | ||
| Pen. | *FV Illertissen | 3-3(3-3) | Nuernberg | ||
| FT | Hansa Rostock | 0-4 (0-1) | Hoffenheim | ||
| FT | SV Hemelingen | 0-9 (0-3) | VFL Wolfsburg | ||
| FT | Sandhausen | 2-4 (2-2) | RB Leipzig | ||
| FT | Energie Cottbus | 1-0 (1-0) | Hannover 96 | ||
| FT | Luebeck | 1-2 (0-1) | Darmstadt | ||
| FT | Sportfreunde Lotte | 0-2 (0-1) | Freiburg |
| FT | AC Oulu | 0-4 (0-0) | Ilves | ||
| FT | IFK Mariehamn | 3-0 (0-0) | FC KTP |
| FT | Paide Linnameeskond | 5-1 (3-1) | FC Kuressaare | ||
| FT | Flora Tallinn | 3-1 (2-0) | Harju Jalgpallikool |
| FT | Halmstads BK | 0-4 (0-3) | Malmoe FF | ||
| FT | IFK Norrkoeping | 2-1 (1-0) | Elfsborg |
| FT | FC Oleksandriya | 1-4 (0-0) | Metalist 1925 | ||
| FT | FC Kolos Kovalivka | 1-1 (1-0) | Karpaty | ||
| FT | Epitsentr Kamianets-Podilskyi | 1-4 (1-2) | Dynamo Kyiv |
| FT | Felgueiras 1932 | 0-1 (0-0) | Maritimo | ||
| FT | Vizela | 4-0 (2-0) | FC Porto B | ||
| FT | Academico Viseu | 0-0 (0-0) | Pacos de Ferreira | ||
| FT | Lusitania Lourosa | 2-2 (0-2) | Chaves |
| FT | Carrick Rangers | 1-0 (1-0) | Glenavon | ||
| FT | Cliftonville | 0-0 (0-0) | Coleraine | ||
| FT | Dungannon Swifts | 1-4 (1-2) | Portadown | ||
| FT | Glentoran | 1-0 (0-0) | Bangor |
| FT | Derby County | 3-5 (2-2) | Coventry City | ||
| FT | Portsmouth | 1-2 (0-2) | Norwich City | ||
| FT | Wrexham | 2-3 (1-1) | West Bromwich Albion | ||
| FT | Blackburn Rovers | 1-2 (0-0) | Birmingham City | ||
| FT | Bristol City | 0-0 (0-0) | Charlton Athletic | ||
| FT | Millwall | 0-3 (0-0) | Middlesbrough | ||
| FT | Preston North End | 2-1 (1-0) | Leicester City | ||
| FT | Sheffield Wednesday | 0-3 (0-1) | Stoke City | ||
| FT | Swansea City | 1-0 (0-0) | Sheffield United | ||
| FT | Watford | 2-1 (2-1) | Queens Park Rangers |
| FT | Kolkheti-1913 Poti | 1-3 (1-1) | Dinamo Tbilisi |
| FT | Tianjin Jinmen Tiger | 2-0 (1-0) | Dalian Yingbo | ||
| FT | Changchun Yatai | 1-0 (1-0) | Meizhou Hakka | ||
| FT | Qingdao West Coast | 1-3 (0-1) | Beijing Guoan | ||
| FT | Shenzhen Peng City | 1-3 (0-2) | Shandong Taishan | ||
| FT | Zhejiang Professional | 0-0 (0-0) | Shanghai Shenhua | ||
| FT | Chengdu Rongcheng FC | 0-0 (0-0) | Qingdao Hainiu |
| FT | Liaoning Tieren | 2-1 (1-0) | Qingdao Red Lions | ||
| FT | Shanghai Jiading | 0-0 (0-0) | Suzhou Dongwu | ||
| FT | Foshan Nanshi | 2-3 (1-1) | Guangdong GZ-Power | ||
| FT | Guangxi Pingguo | 3-1 (2-0) | Dingnan United | ||
| FT | Nantong Zhiyun FC | 2-0 (2-0) | Dalian Kuncheng |
| FT | Cheongju FC | 1-1 (0-0) | Hwaseong FC | ||
| FT | Gimpo FC | 3-1 (1-0) | Suwon Samsung Bluewings | ||
| FT | Gyeongnam FC | 1-1 (0-0) | Seoul E-Land FC | ||
| FT | Incheon United | 1-2 (0-2) | Seongnam FC |
| FT | Jeonbuk Hyundai Motors FC | 3-0 (1-0) | Daegu FC | ||
| FT | Suwon FC | 4-2 (1-1) | Ulsan HD FC |
| FT | Kashima Antlers | 1-1 (0-0) | Avispa Fukuoka | ||
| FT | Shimizu S-Pulse | 1-3 (0-2) | Yokohama F.Marinos | ||
| FT | Albirex Niigata | 1-1 (1-1) | Kawasaki Frontale | ||
| FT | Kyoto Sanga FC | 1-0 (0-0) | Tokyo Verdy | ||
| FT | Machida Zelvia | 3-0 (2-0) | Cerezo Osaka | ||
| FT | Sanfrecce Hiroshima | 1-0 (1-0) | Gamba Osaka | ||
| FT | Shonan Bellmare | 2-2 (0-1) | FC Tokyo | ||
| FT | Urawa Red Diamonds | 2-1 (2-0) | Nagoya Grampus | ||
| FT | Vissel Kobe | 0-1 (0-0) | Yokohama FC |
