| FT | CF America | 1-0 (1-0) | Queretaro FC | ||
| FT | Mazatlan FC | 2-2 (0-1) | Tijuana | ||
| FT | Atlas | 0-3 (0-3) | Pachuca | ||
| FT | Club Universidad Nacional | 1-1 (0-0) | Necaxa | ||
| FT | Santos Laguna | 1-0 (1-0) | CD Guadalajara |
| FT | Austin FC | 2-2 (2-0) | Houston Dynamo FC | ||
| FT | Chicago Fire FC | 2-2 (1-1) | Los Angeles FC | ||
| FT | FC Dallas | 2-0 (1-0) | Portland Timbers | ||
| FT | St. Louis City | 3-1 (2-0) | Nashville SC | ||
| FT | Sporting Kansas City | 0-2 (0-1) | San Diego FC | ||
| FT | San Jose Earthquakes | 2-1 (0-0) | Vancouver Whitecaps | ||
| FT | FC Cincinnati | 0-1 (0-0) | Charlotte FC | ||
| FT | Minnesota United | 1-2 (0-0) | Colorado Rapids | ||
| FT | New York Red Bulls | 2-1 (0-1) | Real Salt Lake | ||
| FT | Orlando City | 4-1 (1-1) | Inter Miami CF | ||
| FT | LA Galaxy | 0-4 (0-2) | Seattle Sounders FC |
| FT | Bucaramanga | 2-1 (1-1) | Santa Fe | ||
| FT | Envigado | 1-1 (1-0) | Junior FC | ||
| FT | Fortaleza FC | 0-0 (0-0) | Deportivo Pereira | ||
| FT | Llaneros FC | 0-1 (0-0) | Independiente Medellin |
| FT | Bahia | 3-3 (2-1) | Fluminense | ||
| FT | Palmeiras | 2-1 (0-0) | Ceara | ||
| FT | Vasco da Gama | 1-1 (1-1) | Atletico MG | ||
| FT | Cruzeiro | 1-2 (1-0) | Santos FC | ||
| FT | Gremio | 0-1 (0-0) | Sport Recife |
| FT | Manta | 0-0 (0-0) | Independiente del Valle | ||
| FT | Vinotinto del Ecuador | 0-1 (0-0) | Tecnico Universitario | ||
| FT | CSD Macara | 0-0 (0-0) | Delfin | ||
| FT | El Nacional | 1-2 (1-2) | Barcelona SC |
| FT | Barracas Central | 3-1 (1-0) | Aldosivi | ||
| FT | Instituto | 1-1 (1-0) | Club Atletico Platense | ||
| FT | Argentinos Juniors | 1-0 (1-0) | Union |
| FT | Guarani | 4-0 (2-0) | Olimpia | ||
| FT | Libertad | 1-1 (0-0) | Recoleta |
| FT | Everton CD | 1-1 (0-1) | Colo Colo | ||
| FT | Cobresal | 1-2 (1-1) | Coquimbo Unido |
| FT | Famalicao | 3-0 (2-0) | Santa Clara | ||
| FT | Braga | 3-0 (2-0) | Tondela | ||
| FT | Moreirense | 2-1 (1-1) | Alverca |
| FT | Vestri | 3-2 (1-1) | Fram Reykjavik | ||
| FT | KA Akureyri | 1-0 (0-0) | IBV Vestmannaeyjar | ||
| FT | Valur | 2-1 (0-1) | Breidablik | ||
| FT | Vikingur Reykjavik | 2-4 (0-2) | Stjarnan |
| FT | Atalanta | 3-3 (2-2) | Opatija | ||
| FT | Naples | 4-0 (2-0) | Sorrento | ||
| FT | Chelsea | 4-1 (2-0) | AC Milan | ||
| FT | Borussia Dortmund | 1-2 (0-1) | Juventus | ||
| FT | Sunderland | 0-3 (0-1) | Rayo Vallecano | ||
| FT | Toulouse | 1-1 (0-1) | FC Séville | ||
| FT | Barcelona | 5-0 (4-0) | Como | ||
| FT | Villarreal | 0-2 (0-1) | Aston Villa |
| FT | Radnik Bijeljina | 2-0 (2-0) | Posusje | ||
| FT | Siroki Brijeg | 1-3 (1-0) | FK Velez Mostar |
| FT | Slaven | 3-1 (1-1) | NK Varazdin | ||
| FT | Hajduk Split | 2-0 (0-0) | HNK Gorica |
| FT | Çaykur Rizespor | 0-3 (0-0) | Goztepe | ||
| FT | Eyupspor | 1-4 (0-3) | Konyaspor |
| FT | Universitatea Craiova | 1-0 (1-0) | Hermannstadt | ||
| FT | FCSB | 0-1 (0-1) | FC Unirea Slobozia |
| FT | Calcio Padova | 0-2 (0-1) | LR Vicenza | ||
| FT | Avellino | 0-1 (0-0) | Audace Cerignola | ||
| FT | Pescara | 1-0 (1-0) | Rimini |
| FT | Radnicki Nis | 2-3 (2-1) | Novi Pazar | ||
| FT | Napredak | 2-7 (0-3) | Partizan Beograd |
| FT | Domzale | 1-3 (0-0) | Olimpija Ljubljana | ||
| FT | NK Celje | 3-0 (1-0) | Mura | ||
| FT | Primorje | 0-2 (0-1) | Maribor |
| FT | Levski Sofia | 2-1 (2-0) | Spartak Varna | ||
| FT | Botev Plovdiv | 0-1 (0-1) | PFC Lokomotiv Sofia 1929 |
| FT | Jagiellonia Bialystok | 5-2 (1-2) | Cracovia | ||
| FT | Legia Warszawa | 3-1 (1-0) | GKS Katowice |
| FT | Bohemians 1905 | 0-1 (0-1) | Jablonec | ||
| FT | Hradec Kralove | 1-1 (1-0) | Pardubice | ||
| FT | Banik Ostrava | 1-2 (0-0) | Karvina | ||
| FT | Sparta Prague | 1-0 (0-0) | Sigma Olomouc |
| FT | Kisvarda | 2-1 (2-1) | Puskas FC Academy | ||
| FT | Zalaegerszegi TE | 1-1 (1-0) | Gyori ETO | ||
| FT | Ujpest | 1-2 (1-1) | Paksi SE |
| FT | FC Orenburg | 0-1 (0-0) | FC Krasnodar | ||
| FT | PFC Sochi | 1-1 (0-1) | Dinamo Moscow | ||
| FT | FC Rostov | 1-0 (0-0) | Nizhny Novgorod |
| FT | Dynamo Brest | 2-0 (1-0) | Naftan Novopolotsk | ||
| FT | Arsenal Dzerzhinsk | 0-4 (0-1) | Maxline Vitebsk | ||
| FT | Dinamo Minsk | 4-0 (3-0) | Torpedo Zhodino |
| FT | RAAL La Louviere | 1-0 (1-0) | Sporting Charleroi | ||
| FT | Anderlecht | 2-3 (0-1) | Zulte Waregem | ||
| FT | Standard Liege | 2-1 (1-0) | RC Genk | ||
| FT | Royal Antwerp | 3-1 (1-0) | OH Leuven |
| FT | Bryne | 0-0 (0-0) | KFUM | ||
| FT | FK Haugesund | 3-2 (0-0) | Sarpsborg 08 | ||
| FT | Sandefjord | 1-2 (1-0) | Viking |
| FT | Chaves | 1-1 (1-1) | Benfica B | ||
| FT | Maritimo | 0-1 (0-0) | Lusitania Lourosa | ||
| FT | Leixoes | 3-0 (2-0) | Felgueiras 1932 | ||
| FT | FC Porto B | 0-0 (0-0) | Feirense | ||
| FT | Uniao de Leiria | 3-2 (1-1) | Academico Viseu |
| FT | FC Kosice | 0-1 (0-0) | Trencin | ||
| FT | Spartak Trnava | 1-0 (1-0) | Tatran Presov |
| FT | FK Tukums 2000 | 1-0 (1-0) | Auda | ||
| FT | Riga FC | 2-0 (0-0) | Grobina | ||
| FT | RFS | 4-1 (3-0) | SK Super Nova |
| FT | Dinamo Tbilisi | 1-1 (0-0) | FC Samgurali Tskhaltubo | ||
| FT | FC Gagra | 0-1 (0-0) | Dila Gori |
| FT | Galway United FC | 0-0 (0-0) | Shamrock Rovers | ||
| FT | St. Patrick's Athletic | 3-0 (0-0) | Sligo Rovers |
| FT | TNS | 0-3 (0-1) | Briton Ferry | ||
| FT | Colwyn Bay | 1-1 (1-1) | Connah's Quay Nomads |
| FT | Hegelmann | 0-1 (0-0) | Dainava Alytus | ||
| FT | Banga Gargzdai | 2-0 (1-0) | Riteriai |
| FT | FC Midtjylland | 3-3 (2-1) | Fredericia | ||
| FT | Silkeborg | 4-2 (2-1) | FC Nordsjaelland | ||
| FT | Broendby IF | 2-1 (2-1) | Vejle Boldklub |
| FT | Nomme JK Kalju | 1-2 (0-1) | Parnu JK Vaprus |
| FT | Leicester City | 2-1 (0-1) | Sheffield Wednesday |
| FT | VPS | 1-2 (1-0) | SJK |
| FT | Obolon Kyiv | 1-0 (0-0) | FC Oleksandriya | ||
| FT | Polissya Zhytomyr | 0-1 (0-0) | FC Kolos Kovalivka | ||
| FT | Karpaty | 3-3 (1-2) | Shakhtar Donetsk |
| FT | Kenya | 1-0 (1-0) | Maroc | ||
| FT | Zambia | 1-2 (0-0) | Angola |
| FT | Austria Wien | 0-2 (0-2) | Wolfsberger AC | ||
| FT | Sturm Graz | 1-2 (0-0) | Rapid Vienne | ||
| FT | WSG Tirol | 3-1 (2-0) | LASK |
| FT | PEC Zwolle | 1-0 (1-0) | FC Twente | ||
| FT | AZ Alkmaar | 4-1 (3-1) | FC Groningen | ||
| FT | Ajax Amsterdam | 2-0 (1-0) | Telstar | ||
| FT | FC Utrecht | 4-0 (1-0) | Heracles |
| FT | Young Boys | 0-0 (0-0) | Sion | ||
| FT | Lausanne | 1-2 (1-1) | FC Zürich | ||
| FT | Lugano | 3-1 (2-0) | FC Bâle | ||
| FT | Servette | 1-1 (0-1) | Grasshopper Zurich |
| FT | AIK | 0-0 (0-0) | Djurgaarden | ||
| FT | Degerfors | 0-0 (0-0) | Haecken | ||
| FT | IFK Norrkoeping | 0-2 (0-0) | Hammarby | ||
| FT | Oesters IF | 1-1 (1-0) | Brommapojkarna |
| FT | Club Brugge NXT | 1-1 (0-0) | Francs Borains |
| FT | Atert Bissen | 0-0 (0-0) | AS Jeunesse Esch | ||
| FT | Racing FC Union Luxembourg | 1-3 (0-1) | FC Jeunesse Canach | ||
| FT | US Hostert | 0-0 (0-0) | FC Rodange 91 | ||
| FT | Una Strassen | 2-4 (1-0) | Swift Hesperange | ||
| FT | Union Titus Petange | 1-1 (0-0) | FC Victoria Rosport |
| FT | Bangor | 3-1 (1-0) | Cliftonville | ||
| FT | Coleraine | 1-0 (0-0) | Larne | ||
| FT | Linfield | 3-0 (0-0) | Dungannon Swifts |
| FT | Aberdeen | 0-2 (0-1) | Celtic | ||
| FT | Dundee United | 2-3 (2-1) | Hearts | ||
| FT | Hibernian | 2-2 (2-1) | Kilmarnock |
| Pen. | *Crystal Palace | 2-2(2-2) | Liverpool |
| FT | Tianjin Jinmen Tiger | 0-0 (0-0) | Qingdao West Coast | ||
| FT | Zhejiang Professional | 3-4 (2-1) | Beijing Guoan | ||
| FT | Wuhan Three Towns | 1-2 (0-1) | Meizhou Hakka |
| FT | Hertha Berlin | 0-0 (0-0) | Karlsruher SC | ||
| FT | Holstein Kiel | 0-2 (0-2) | Arminia Bielefeld | ||
| FT | VFL Bochum | 2-0 (0-0) | Elversberg |
| FT | Suzhou Dongwu | 1-1 (1-1) | Shijiazhuang Gongfu | ||
| FT | Dingnan United | 3-0 (0-0) | Foshan Nanshi | ||
| FT | Guangdong GZ-Power | 0-1 (0-0) | Guangxi Pingguo | ||
| FT | Qingdao Red Lions | 1-0 (0-0) | Shanghai Jiading |
| FT | Jeonnam Dragons | 3-4 (0-0) | Cheonan City | ||
| FT | Seoul E-Land FC | 0-0 (0-0) | Hwaseong FC | ||
| FT | Cheongju FC | 0-1 (0-0) | Bucheon FC 1995 |
| FT | Daejeon Hana Citizen | 3-2 (1-2) | Suwon FC | ||
| FT | Pohang Steelers | 1-0 (1-0) | Gwangju FC |
| FT | Sanfrecce Hiroshima | 0-0 (0-0) | Shimizu S-Pulse | ||
| FT | FC Tokyo | 0-1 (0-0) | Kashima Antlers | ||
| FT | Gamba Osaka | 0-3 (0-2) | Fagiano Okayama FC | ||
| FT | Kashiwa Reysol | 2-0 (1-0) | Shonan Bellmare | ||
| FT | Machida Zelvia | 2-0 (2-0) | Vissel Kobe | ||
| FT | Nagoya Grampus | 1-2 (0-0) | Kyoto Sanga FC |
