| FT | Orlando City | 5-1 (4-0) | Necaxa | ||
| FT | Atlanta United | 4-1 (3-0) | Atlas | ||
| FT | Inter Miami CF | 3-1 (1-1) | Club Universidad Nacional | ||
| FT | Minnesota United | 0-2 (0-1) | Atletico de San Luis | ||
| Pen. | *CF America | 1-1(1-1) | Portland Timbers | ||
| FT | Real Salt Lake | 1-0 (1-0) | Queretaro FC | ||
| FT | Seattle Sounders FC | 2-1 (0-1) | Tijuana | ||
| FT | Monterrey | 0-2 (0-0) | Charlotte FC | ||
| Pen. | *New York Red Bulls | 1-1(1-1) | FC Juarez | ||
| Pen. | *Cruz Azul | 2-2(2-2) | Colorado Rapids | ||
| FT | FC Cincinnati | 1-2 (0-1) | CD Guadalajara | ||
| FT | LA Galaxy | 4-0 (3-0) | Santos Laguna |
| Pen. | *Atletico MG | 0-1(0-1) | Flamengo | ||
| FT | Red Bull Bragantino | 0-1 (0-0) | Botafogo RJ | ||
| Pen. | *Athletico Paranaense | 1-0(1-0) | Sao Paulo | ||
| FT | Retro FC | 0-0 (0-0) | Bahia | ||
| FT | Fluminense | 1-1 (0-0) | Internacional | ||
| FT | Palmeiras | 0-2 (0-1) | Corinthians | ||
| FT | Vasco da Gama | 3-1 (3-0) | CS Alagoano | ||
| FT | CRB | 0-2 (0-1) | Cruzeiro |
| FT | Godoy Cruz | 1-2 (0-2) | Gimnasia LP | ||
| FT | San Lorenzo | 1-0 (1-0) | Velez Sarsfield | ||
| FT | Estudiantes | 2-1 (2-0) | Independiente Rivadavia |
| FT | Union Magdalena | 1-1 (1-0) | Deportivo Pasto |
| FT | Bayern Munich | 4-0 (1-0) | Tottenham Hotspur | ||
| FT | Al Nassr FC | 4-0 (2-0) | Rio Ave |
| FT | Araz PFK | 0-4 (0-2) | Omonia Nicosia | ||
| FT | Aris Limassol | 2-2 (2-2) | AEK Athens | ||
| FT | FC Milsami Orhei | 3-2 (1-0) | Virtus Acquaviva | ||
| FT | FK Kauno Zalgiris | 0-1 (0-0) | Arda Kardzhali | ||
| FT | Rosenborg | 0-0 (0-0) | Hammarby | ||
| FT | Banik Ostrava | 4-3 (2-1) | Austria Wien | ||
| FT | AIK | 2-1 (2-0) | Gyori ETO | ||
| FT | Riga FC | 3-0 (0-0) | Beitar Jerusalem | ||
| FT | Silkeborg | 0-1 (0-1) | Jagiellonia Bialystok | ||
| FT | Viking | 1-3 (1-0) | Istanbul Basaksehir | ||
| FT | AZ Alkmaar | 3-0 (1-0) | FC Vaduz | ||
| FT | Anderlecht | 3-0 (1-0) | FC Sheriff | ||
| FT | FC Differdange 03 | 2-3 (1-2) | FCI Levadia | ||
| FT | Levski Sofia | 1-0 (0-0) | Sabah FK | ||
| FT | Olimpija Ljubljana | 0-0 (0-0) | Egnatia | ||
| FT | Polissya Zhytomyr | 3-0 (2-0) | Paksi SE | ||
| FT | Sparta Prague | 4-1 (2-1) | Ararat Armenia | ||
| FT | Vikingur | 2-1 (1-1) | Linfield | ||
| FT | Lausanne | 3-1 (2-0) | FC Astana | ||
| FT | Ballkani | 1-0 (0-0) | Shamrock Rovers | ||
| FT | Lugano | 0-5 (0-2) | NK Celje | ||
| FT | Universitatea Craiova | 3-0 (0-0) | Spartak Trnava | ||
| FT | St. Patrick's Athletic | 1-4 (0-4) | Besiktas | ||
| FT | Vikingur Reykjavik | 3-0 (1-0) | Broendby IF | ||
| FT | Hajduk Split | 2-1 (0-1) | FC Dinamo City | ||
| FT | Larne | 0-3 (0-3) | Santa Clara | ||
| FT | Partizan Beograd | 0-2 (0-1) | Hibernian | ||
| FT | Rakow Czestochowa | 0-1 (0-0) | Maccabi Haifa | ||
| FT | Rapid Vienne | 2-2 (2-1) | Dundee United |
| FT | Fredrikstad | 1-3 (0-2) | FC Midtjylland | ||
| FT | Lincoln Red Imps FC | 1-1 (1-1) | FC Noah | ||
| FT | AEK Larnaca | 4-1 (1-1) | Legia Warszawa | ||
| FT | CFR 1907 Cluj | 1-2 (1-1) | Braga | ||
| FT | Haecken | 0-2 (0-1) | Brann | ||
| FT | PAOK Thessaloniki FC | 0-0 (0-0) | Wolfsberger AC | ||
| FT | Panathinaikos | 0-0 (0-0) | Shakhtar Donetsk | ||
| FT | Zrinjski Mostar | 1-1 (0-1) | Breidablik | ||
| FT | FCSB | 3-2 (0-1) | Drita | ||
| FT | Servette | 1-3 (1-0) | FC Utrecht |
| FT | DR Congo | 2-0 (0-0) | Zambia | ||
| FT | Angola | 1-1 (1-1) | Kenya |
| FT | Zalgiris Vilnius | 1-0 (1-0) | Suduva |
