| FT | CF Montreal | 1-2 (0-0) | Puebla | ||
| FT | Houston Dynamo FC | 1-2 (0-1) | Pachuca | ||
| FT | Mazatlan FC | 0-2 (0-0) | San Diego FC | ||
| FT | Tigres | 1-2 (0-1) | Los Angeles FC | ||
| FT | Orlando City | 5-1 (4-0) | Necaxa | ||
| FT | Atlanta United | 4-1 (3-0) | Atlas | ||
| FT | Inter Miami CF | 3-1 (1-1) | Club Universidad Nacional | ||
| FT | Minnesota United | 0-2 (0-1) | Atletico de San Luis | ||
| Pen. | *CF America | 1-1(1-1) | Portland Timbers | ||
| FT | Real Salt Lake | 1-0 (1-0) | Queretaro FC | ||
| FT | Seattle Sounders FC | 2-1 (0-1) | Tijuana |
| Pen. | *Atletico MG | 0-1(0-1) | Flamengo | ||
| FT | Red Bull Bragantino | 0-1 (0-0) | Botafogo RJ | ||
| Pen. | *Athletico Paranaense | 1-0(1-0) | Sao Paulo | ||
| FT | Retro FC | 0-0 (0-0) | Bahia | ||
| FT | Fluminense | 1-1 (0-0) | Internacional | ||
| FT | Palmeiras | 0-2 (0-1) | Corinthians |
| FT | Afturelding | 1-1 (0-1) | Vestri | ||
| FT | Fram Reykjavik | 1-1 (0-0) | Stjarnan |
| FT | Atalanta | 2-1 (0-1) | Monza | ||
| FT | Lille | 3-0 (2-0) | Venezia | ||
| FT | Paris FC | 2-2 (1-1) | UNFP FC | ||
| FT | Strasbourg | 3-2 (2-0) | Sturm Graz | ||
| Pen. | Arsenal | 2-3(2-3) | Villarreal* | ||
| FT | Deportivo La Coruna | 2-1 (0-0) | Real Oviedo | ||
| FT | Osasuna | 3-0 (2-0) | CD Mirandes | ||
| FT | Poblense | 0-2 (0-1) | Mallorca | ||
| FT | Real Betis | 2-3 (0-2) | Como | ||
| FT | Aston Villa | 4-0 (3-0) | Roma |
| FT | Kairat Almaty | 1-0 (0-0) | Slovan Bratislava | ||
| FT | Red Bull Salzbourg | 0-1 (0-0) | Club Brugge | ||
| FT | Ludogorets Razgrad | 0-0 (0-0) | Ferencvarosi TC | ||
| FT | Lech Poznan | 1-3 (1-1) | FK Crvena Zvezda | ||
| FT | Feyenoord | 2-1 (1-0) | Fenerbahce | ||
| FT | Nice | 0-2 (0-0) | Benfica |
| FT | RFS | 1-2 (0-2) | KuPS | ||
| FT | Rijeka | 1-2 (0-0) | Shelbourne |
| FT | FC Bâle | 4-1 (1-1) | Young Boys |
| FT | Burkina Faso | 4-2 (1-1) | Central African Republic | ||
| FT | Mauritanie | 0-1 (0-0) | Tanzania |
