| FT | Alianza FC | 0-1 (0-1) | Tolima | ||
| FT | Santa Fe | 0-0 (0-0) | Aguilas Doradas | ||
| FT | Deportivo Pereira | 2-1 (2-1) | Atletico Nacional |
| FT | Cerro Largo | 0-3 (0-1) | Central Cordoba de Santiago | ||
| FT | America de Cali | 2-0 (1-0) | Bahia | ||
| FT | Vasco da Gama | 1-1 (0-1) | Independiente del Valle |
| AP | Angleterre F | AP 2-1 | Italie F |
| FT | Bristol City | 1-0 (0-0) | Newport County | ||
| FT | Borussia Moenchengladbach | 1-3 (1-1) | Metalist 1925 | ||
| FT | Naples | 0-2 (0-1) | S.S. Arezzo | ||
| FT | Telstar | 3-3 (1-1) | Samsunspor | ||
| FT | Deportivo Alaves | 1-0 (0-0) | Athletic Bilbao | ||
| FT | Nancy | 1-2 (0-1) | Strasbourg | ||
| FT | Qatar SC | 1-5 (1-2) | Blackburn Rovers | ||
| FT | Saint-Gall | 2-2 (1-0) | Villarreal | ||
| FT | AFC Wimbledon | 0-3 (0-2) | Millwall | ||
| FT | Mansfield Town | 0-1 (0-1) | Oxford United | ||
| FT | Walsall | 2-3 (2-1) | Derby County | ||
| FT | Burton Albion | 1-2 (1-0) | Sheffield United |
| FT | KuPS | 2-0 (0-0) | Kairat Almaty | ||
| FT | FC Noah | 1-2 (1-1) | Ferencvarosi TC | ||
| FT | Lincoln Red Imps FC | 0-1 (0-1) | FK Crvena Zvezda | ||
| FT | FC Koebenhavn | 2-0 (0-0) | Drita | ||
| FT | Hamrun Spartans | 0-3 (0-1) | Dynamo Kyiv | ||
| FT | Pafos FC | 1-1 (0-0) | Maccabi Tel Aviv | ||
| FT | RFS | 1-4 (1-2) | Malmoe FF | ||
| FT | Viktoria Plzen | 0-1 (0-1) | Servette | ||
| FT | KF Shkendija | 1-0 (0-0) | FCSB | ||
| FT | Slovan Bratislava | 4-0 (2-0) | Zrinjski Mostar | ||
| FT | Lech Poznan | 7-1 (5-1) | Breidablik | ||
| FT | Rangers | 2-0 (0-0) | Panathinaikos | ||
| FT | Rijeka | 0-0 (0-0) | Ludogorets Razgrad |
| FT | Dunfermline Athletic | 2-1 (1-0) | Hamilton Academical |
| FT | East Kilbride | 2-6 (1-1) | Inverness CT | ||
| FT | St. Johnstone | 3-1 (1-0) | Raith Rovers |
| FT | Arbroath | 6-0 (3-0) | Annan Athletic | ||
| FT | Ayr United | 3-0 (3-0) | Forfar Athletic |
| Pen. | *Clyde | 2-2(2-2) | Stenhousemuir | ||
| FT | Motherwell | 3-0 (0-0) | Greenock Morton |
| FT | Bonnyrigg Rose | 1-3 (1-1) | Dundee FC |
| FT | East Fife | 3-0 (2-0) | Brora Rangers | ||
| Pen. | *Kelty Hearts | 0-0(0-0) | Kilmarnock |
| FT | Partick Thistle | 2-0 (2-0) | Queen of the South | ||
| FT | Ross County | 8-0 (3-0) | Edinburgh City |
| FT | Brechin City | 0-3 (0-3) | Cove Rangers | ||
| FT | Falkirk | 3-1 (1-1) | Queen's Park |
| FT | Ballkani | 4-2 (3-2) | Floriana |
| FT | Tanzania | 1-0 (1-0) | Uganda |
| Pen. | Qingdao West Coast | 2-2(1-1) | Beijing Guoan* | ||
| FT | Yunnan Yukun | 3-0 (2-0) | Guangdong GZ-Power |
| FT | FC Anyang | 4-0 (2-0) | Daegu FC | ||
| FT | Gwangju FC | 1-1 (1-0) | Gimcheon Sangmu | ||
| FT | Pohang Steelers | 1-5 (1-2) | Suwon FC |
| FT | Defensa y Justicia | 2-0 (0-0) | Aldosivi | ||
| FT | San Martin San Juan | 3-2 (1-1) | Deportivo Riestra |
| FT | Libertad | 1-0 (0-0) | Manta |
