| FT | Instituto | 0-4 (0-2) | River Plate | ||
| FT | Barracas Central | 0-3 (0-0) | Independiente Rivadavia | ||
| FT | Newell's Old Boys | 1-2 (0-1) | Banfield | ||
| FT | Tigre | 2-1 (0-0) | Argentinos Juniors | ||
| FT | Belgrano | 0-1 (0-0) | Racing Club | ||
| FT | Independiente | 1-2 (0-1) | Talleres |
| FT | Delfin | 0-1 (0-0) | Barcelona SC | ||
| FT | Tecnico Universitario | 1-0 (1-0) | CSD Macara | ||
| FT | Emelec | 1-0 (1-0) | Mushuc Runa | ||
| FT | LDU de Quito | 2-2 (0-1) | Deportivo Cuenca |
| FT | Sao Paulo | 2-0 (2-0) | Corinthians | ||
| FT | Internacional | 1-0 (1-0) | Ceara | ||
| FT | Cruzeiro | 4-0 (1-0) | Juventude | ||
| FT | Vitoria | 1-0 (1-0) | Red Bull Bragantino | ||
| FT | Palmeiras | 3-2 (1-1) | Atletico MG | ||
| FT | Sport Recife | 0-1 (0-0) | Botafogo RJ | ||
| FT | Flamengo | 1-0 (0-0) | Fluminense |
| FT | Chico FC | 2-0 (0-0) | Independiente Medellin | ||
| FT | Envigado | 0-0 (0-0) | Deportivo Cali | ||
| FT | Fortaleza FC | 2-1 (2-1) | Once Caldas |
| FT | Cerro Porteno | 0-0 (0-0) | Luqueno | ||
| FT | Guarani | 0-0 (0-0) | Sportivo Trinidense |
| FT | Vikingur Reykjavik | 1-2 (0-1) | Valur |
| FT | BW Linz | 4-0 (1-0) | Donau Linz | ||
| FT | Reims | 0-1 (0-0) | OH Leuven | ||
| FT | Royal Antwerp | 2-0 (0-0) | Eupen | ||
| FT | Dynamo Dresden | 0-2 (0-2) | VFL Wolfsburg | ||
| FT | Ulm | 3-0 (1-0) | FC Zürich | ||
| FT | FSV Zwickau | 0-2 (0-2) | VFL Wolfsburg | ||
| FT | Karlsruher SC | 1-6 (0-3) | St. Pauli | ||
| FT | Trabzonspor | 4-0 (1-0) | Zob Ahan | ||
| FT | Union Berlin | 1-1 (1-0) | Rapid Vienne | ||
| FT | Bologna | 7-0 (3-0) | Virtus Verona | ||
| FT | Excelsior Maassluis | 0-5 (0-5) | Marseille | ||
| FT | Galatasaray | 2-1 (1-0) | Admira Wacker | ||
| FT | Uniao de Leiria | 0-2 (0-0) | Fenerbahce |
| FT | Audax Italiano | 1-1 (0-1) | Universidad Catolica | ||
| FT | CD Nublense | 2-2 (0-0) | Universidad de Chile |
| FT | FCV Farul Constanta | 3-2 (2-1) | Otelul Galati | ||
| FT | Rapid Bucuresti | 1-1 (0-1) | CFR 1907 Cluj |
| FT | Koper | 2-1 (0-0) | NK Bravo | ||
| FT | Maribor | 1-2 (1-0) | NK Celje |
| FT | Slavia Sofia | 2-2 (0-2) | Botev Vratsa | ||
| FT | Levski Sofia | 5-0 (2-0) | Montana |
| FT | Gornik Zabrze | 2-1 (1-0) | Lechia Gdansk | ||
| FT | Motor Lublin | 1-0 (0-0) | Arka Gdynia | ||
| FT | Radomiak Radom | 5-1 (1-0) | Pogon Szczecin |
| FT | Slovacko | 0-1 (0-0) | Sigma Olomouc | ||
| FT | Mlada Boleslav | 3-3 (1-1) | Slovan Liberec | ||
| FT | Slavia Prague | 2-2 (0-1) | Hradec Kralove |
| FT | Mladost Lucani | 1-1 (1-1) | FK IMT Beograd | ||
| FT | TSC Backa Topola | 2-1 (1-1) | Radnicki Nis | ||
| FT | Vojvodina | 2-0 (1-0) | FK Radnik Surdulica | ||
| FT | Zeleznicar Pancevo | 0-1 (0-0) | Partizan Beograd |
| FT | Leon | 1-0 (0-0) | CD Guadalajara | ||
| FT | Tigres | 1-0 (0-0) | FC Juarez | ||
| FT | Atlas | 3-3 (2-0) | Cruz Azul | ||
| FT | Club Universidad Nacional | 2-3 (2-2) | Pachuca |
| FT | Fredericia | 2-3 (1-3) | FC Nordsjaelland | ||
| FT | Vejle Boldklub | 1-1 (0-0) | Randers FC | ||
| FT | Soenderjyske Fodbold | 1-1 (0-1) | AGF | ||
| FT | FC Midtjylland | 3-3 (2-2) | OB | ||
| FT | Broendby IF | 3-0 (1-0) | Silkeborg |
| FT | Nizhny Novgorod | 0-3 (0-1) | FC Krasnodar | ||
| FT | Zenit St. Petersburg | 2-1 (0-1) | FC Rostov | ||
| FT | FK Akhmat | 0-2 (0-1) | Rubin Kazan |
| FT | Vaalerenga | 3-0 (0-0) | FK Haugesund | ||
| FT | Sandefjord | 6-0 (4-0) | Kristiansund BK | ||
| FT | Tromsoe | 3-1 (1-0) | Bryne | ||
| FT | Hamarkameratene | 1-1 (1-0) | Fredrikstad |
| FT | FK Panevezys | 2-0 (1-0) | FA Siauliai | ||
| FT | Suduva | 0-0 (0-0) | Riteriai |
| FT | Nomme JK Kalju | 6-2 (3-0) | Talinna Kalev | ||
| FT | Tammeka | 1-2 (1-2) | Flora Tallinn | ||
| FT | FC Kuressaare | 2-1 (0-1) | Parnu JK Vaprus | ||
| FT | Paide Linnameeskond | 2-0 (1-0) | Narva Trans |
| FT | SJK | 3-1 (0-1) | IF Gnistan | ||
| FT | FF Jaro | 0-1 (0-0) | Ilves | ||
| FT | HJK | 3-1 (2-0) | AC Oulu |
| FT | Mjaellby | 2-0 (0-0) | AIK | ||
| FT | Sirius | 0-1 (0-0) | IFK Göteborg | ||
| FT | Halmstads BK | 0-0 (0-0) | Haecken | ||
| FT | Hammarby | 3-2 (0-2) | Brommapojkarna |
| FT | Auda | 1-3 (0-0) | BFC Daugavpils | ||
| FT | FK Jelgava | 1-0 (1-0) | SK Super Nova |
| FT | Dingnan United | 2-0 (0-0) | Shaanxi Union | ||
| FT | Nanjing City FC | 2-1 (0-1) | Guangxi Pingguo |
| FT | Bucheon FC 1995 | 5-3 (2-1) | Chungnam Asan FC | ||
| FT | Cheongju FC | 2-1 (1-1) | Cheonan City | ||
| FT | Gyeongnam FC | 0-2 (0-0) | Incheon United |
| FT | FC Seoul | 1-0 (1-0) | Ulsan HD FC |
| FT | Kashima Antlers | 3-2 (2-1) | Kashiwa Reysol | ||
| FT | Tokyo Verdy | 0-1 (0-0) | Machida Zelvia | ||
| FT | Shimizu S-Pulse | 2-0 (0-0) | Yokohama FC | ||
| FT | Albirex Niigata | 0-2 (0-1) | Sanfrecce Hiroshima | ||
| FT | Fagiano Okayama FC | 1-2 (0-1) | Vissel Kobe | ||
| FT | Gamba Osaka | 2-1 (1-1) | Kawasaki Frontale | ||
| FT | Yokohama F.Marinos | 3-0 (2-0) | Nagoya Grampus |
| FT | FC Dallas | 3-0 (1-0) | St. Louis City | ||
| FT | Houston Dynamo FC | 1-1 (1-1) | Philadelphia Union | ||
| FT | Seattle Sounders FC | 3-2 (1-1) | San Jose Earthquakes | ||
| FT | Sporting Kansas City | 1-1 (0-1) | New York City FC | ||
| FT | Nashville SC | 1-0 (1-0) | Toronto FC | ||
| FT | Real Salt Lake | 0-1 (0-0) | FC Cincinnati | ||
| FT | Los Angeles FC | 3-3 (2-1) | LA Galaxy | ||
| FT | Portland Timbers | 1-1 (0-0) | Minnesota United | ||
| FT | San Diego FC | 1-1 (0-1) | Vancouver Whitecaps |
