| FT | CF America | 3-1 (1-0) | Tijuana | ||
| FT | Santos Laguna | 2-4 (2-1) | Toluca |
| FT | Atlanta United | 2-2 (0-1) | Chicago Fire FC | ||
| FT | Charlotte FC | 2-1 (1-0) | DC United | ||
| FT | FC Cincinnati | 3-0 (1-0) | Inter Miami CF | ||
| FT | New York Red Bulls | 5-3 (0-2) | New England Revolution | ||
| FT | Philadelphia Union | 2-1 (1-1) | CF Montreal | ||
| FT | Orlando City | 1-2 (1-0) | New York City FC | ||
| FT | Houston Dynamo FC | 0-3 (0-2) | Vancouver Whitecaps | ||
| FT | Minnesota United | 0-1 (0-1) | Los Angeles FC | ||
| FT | Nashville SC | 3-0 (2-0) | Columbus Crew | ||
| FT | Seattle Sounders FC | 3-3 (2-0) | Colorado Rapids | ||
| FT | LA Galaxy | 1-2 (0-1) | Austin FC | ||
| FT | Portland Timbers | 0-1 (0-0) | Real Salt Lake | ||
| FT | San Diego FC | 0-1 (0-1) | Toronto FC | ||
| FT | San Jose Earthquakes | 2-2 (1-1) | FC Dallas |
| FT | Bahia | 0-0 (0-0) | America de Cali | ||
| FT | Independiente del Valle | 4-0 (1-0) | Vasco da Gama | ||
| FT | Bolivar | 3-0 (0-0) | Palestino | ||
| FT | Alianza Lima | 2-0 (0-0) | Gremio | ||
| FT | San Antonio Bulo Bulo | 0-3 (0-0) | Once Caldas |
| FT | Palmeiras | 1-1 (0-0) | Mirassol | ||
| FT | Ceara | 0-1 (0-0) | Corinthians | ||
| FT | Santos FC | 1-0 (0-0) | Flamengo | ||
| FT | Botafogo RJ | 0-0 (0-0) | Vitoria | ||
| FT | Red Bull Bragantino | 2-2 (1-1) | Sao Paulo |
| FT | Nacional | 3-0 (1-0) | Machico | ||
| FT | St.Truiden | 1-0 (1-0) | MVV Maastricht | ||
| FT | Estoril | 2-3 (0-0) | Maritimo | ||
| FT | Club Brugge | 3-0 (0-0) | NK Lokomotiva | ||
| FT | FC Bâle | 1-1 (1-0) | Wil | ||
| FT | VFL Bochum | 3-2 (0-1) | Waldhof Mannheim | ||
| FT | Academico Viseu | 1-1 (1-0) | Tondela | ||
| FT | Ajax Amsterdam | 2-1 (1-0) | PAOK Thessaloniki FC | ||
| FT | Braga | 2-0 (1-0) | Moreirense | ||
| FT | Farense | 1-1 (0-0) | Santa Clara | ||
| FT | Young Boys | 1-1 (1-0) | Huddersfield Town | ||
| FT | Nice | 3-0 (1-0) | Aubagne | ||
| FT | Goztepe | 2-1 (1-0) | Kryvbas | ||
| FT | Angers | 0-1 (0-1) | Les Herbiers | ||
| FT | Coventry City | 0-5 (0-2) | Monaco | ||
| FT | Grasshopper Zurich | 2-1 (1-0) | FC Rapperswil-Jona | ||
| FT | Paris FC | 0-1 (0-0) | Union St.Gilloise | ||
| FT | SF Lauffen | 0-11 (0-6) | Hoffenheim | ||
| FT | US Mondorf les Bains | 0-1 (0-0) | Metz | ||
| FT | VFL Bochum | 5-4 (1-4) | Young Boys | ||
| FT | Vitoria de Guimaraes | 10-0 (9-0) | Ponferradina | ||
| FT | Wolfsberger AC | 3-2 (2-2) | Besiktas | ||
| FT | FC Twente | 2-1 (1-0) | Kaizer Chiefs | ||
| FT | KV Mechelen | 2-2 (0-2) | KSK Heist | ||
| FT | Saarbruecken | 1-4 (0-4) | Mainz 05 | ||
| FT | Stoke City | 1-3 (1-1) | Brighton & Hove Albion | ||
| FT | Winterthur | 3-1 (3-1) | FC Dietikon | ||
| FT | La Gantoise | 1-2 (1-1) | AZ Alkmaar | ||
| FT | Farnborough | 0-5 (0-1) | Portsmouth | ||
| FT | Panathinaikos | 3-1 (1-0) | Westerlo | ||
| FT | Sporting CP | 0-2 (0-0) | Celtic | ||
| FT | Walsall | 1-0 (1-0) | Aston Villa | ||
| FT | Richmond Kickers | 1-1 (1-1) | Leganes |
| FT | Norvège F | 1-2 (0-0) | Italie F |
| AP | Dinamo Minsk | AP 2-2 | Ludogorets Razgrad | ||
| FT | Linfield | 1-1 (1-1) | Shelbourne |
| FT | Kilmarnock | 1-0 (1-0) | Livingston |
| Pen. | Auda | 2-2(2-2) | Larne* |
| FT | Fredrikstad | 0-1 (0-0) | Bodoe/Glimt |
