| FT | Deportes Iquique | 0-1 (0-0) | Union La Calera | ||
| FT | Audax Italiano | 4-3 (1-2) | Huachipato |
| FT | Red Bull Bragantino | 1-0 (1-0) | Juventude |
| FT | Sportivo Ameliano | 2-0 (0-0) | Atletico Tembetary | ||
| FT | Recoleta | 1-2 (0-1) | Sportivo Trinidense |
| FT | Ross County | 2-4 (2-1) | Livingston |
| FT | US Biskra | 0-2 (0-2) | MC Oran | ||
| FT | USM Alger | 1-1 (0-0) | Olympique Akbou |
| FT | Elversberg | 1-2 (1-1) | FC Heidenheim |
| FT | Al Fateh FC | 3-2 (1-1) | Al Nassr FC | ||
| FT | Al Hilal | 2-0 (1-0) | Al Qadasiya | ||
| FT | Al Ittihad | 1-0 (0-0) | Damac FC | ||
| FT | Al Khaleej | 2-3 (0-0) | Al Akhdoud | ||
| FT | Al Riyadh | 0-1 (0-1) | Al Ahli | ||
| FT | Al-Ettifaq | 2-1 (1-0) | Al-Wehda | ||
| FT | Al-Fayha | 0-2 (0-1) | Al Shabab | ||
| FT | Al-Orobah FC | 3-2 (2-2) | Al-Taawoun | ||
| FT | Al-Raed | 1-2 (0-1) | Al Kholood |
| FT | BATE Borisov | 2-2 (2-1) | FC Smorgon |
| FT | Beroe | 3-1 (2-1) | Spartak Varna | ||
| FT | Botev Plovdiv | 0-4 (0-1) | PFK CSKA Sofia |
| FT | IFK Norrkoeping | 1-1 (0-1) | Mjaellby | ||
| FT | Hammarby | 1-0 (0-0) | Degerfors |
| FT | FC Voluntari | 2-1 (1-1) | FC Unirea Slobozia |
| FT | LASK | 2-0 (1-0) | Hartberg |
| FT | KFUM | 0-1 (0-0) | Vaalerenga |
| FT | Hatayspor | 4-2 (1-1) | Fenerbahce |
| FT | SV Glehn | 2-14 (0-10) | Borussia Moenchengladbach |
| FT | Grobina | 1-1 (1-0) | SK Super Nova |
| FT | Cherno More Varna | 0-0 (0-0) | Levski Sofia | ||
| FT | Ludogorets Razgrad | 2-2 (1-1) | Arda Kardzhali |
| FT | Yanbian Longding | 3-0 (2-0) | Dingnan United | ||
| FT | Qingdao Red Lions | 0-1 (0-0) | Nantong Zhiyun FC | ||
| FT | Shenzhen Juniors | 2-1 (2-0) | Guangdong GZ-Power |
| FT | Toluca | 2-0 (0-0) | CF America |
