| FT | Toluca | 2-0 (0-0) | CF America |
| FT | Coquimbo Unido | 0-0 (0-0) | Palestino | ||
| FT | CD Nublense | 0-1 (0-0) | O'Higgins | ||
| FT | Universidad Catolica | 1-3 (0-1) | La Serena | ||
| FT | Deportes Iquique | 0-1 (0-0) | Union La Calera |
| FT | Atletico MG | 0-0 (0-0) | Corinthians | ||
| FT | Gremio | 1-0 (0-0) | Bahia | ||
| FT | Palmeiras | 0-2 (0-0) | Flamengo | ||
| FT | Sport Recife | 1-1 (1-0) | Internacional | ||
| FT | Vitoria | 0-1 (0-1) | Santos FC | ||
| FT | Fortaleza | 0-2 (0-2) | Cruzeiro |
| FT | Orense | 2-1 (2-0) | Aucas | ||
| FT | Libertad | 0-1 (0-0) | CSD Macara | ||
| FT | Tecnico Universitario | 1-2 (0-0) | Delfin | ||
| FT | El Nacional | 2-0 (2-0) | Emelec |
| FT | Minnesota United | 1-1 (1-1) | Austin FC | ||
| FT | Sporting Kansas City | 3-3 (0-2) | New England Revolution | ||
| FT | Colorado Rapids | 1-0 (1-0) | St. Louis City | ||
| FT | Real Salt Lake | 2-3 (2-2) | Vancouver Whitecaps | ||
| FT | San Jose Earthquakes | 3-3 (0-1) | Houston Dynamo FC | ||
| FT | New York City FC | 3-1 (0-1) | Chicago Fire FC | ||
| FT | Atlanta United | 4-2 (2-0) | FC Cincinnati |
| FT | Alianza FC | 6-1 (3-0) | Santa Fe | ||
| FT | America de Cali | 2-0 (0-0) | Independiente Medellin | ||
| FT | Atletico Nacional | 2-3 (0-2) | Junior FC | ||
| FT | Bucaramanga | 2-1 (1-1) | Deportivo Pasto | ||
| FT | Millonarios | 4-2 (1-2) | Chico FC | ||
| FT | Once Caldas | 1-0 (1-0) | Deportivo Cali | ||
| FT | Tolima | 1-2 (0-0) | Aguilas Doradas |
| FT | Nacional | 1-1 (1-0) | Olimpia |
| FT | FH Hafnarfjordur | 2-0 (1-0) | Breidablik |
| FT | St. Kitts and Nevis | 0-3 (0-0) | Saint Vincent and The Grenadines |
| FT | San Lorenzo | 0-1 (0-0) | Club Atletico Platense |
| FT | Girona | 0-4 (0-0) | Atletico Madrid | ||
| FT | Villarreal | 4-2 (3-1) | FC Séville | ||
| FT | Athletic Bilbao | 0-3 (0-2) | Barcelona |
| FT | Atalanta | 2-3 (2-0) | Parma Calcio 1913 | ||
| FT | Empoli | 1-2 (1-1) | Hellas Verona | ||
| FT | Lazio | 0-1 (0-1) | Lecce | ||
| FT | Torino | 0-2 (0-1) | Roma | ||
| FT | Udinese | 2-3 (1-0) | Fiorentina | ||
| FT | Venezia | 2-3 (1-2) | Juventus |
| FT | Botev Vratsa | 2-1 (1-1) | Slavia Sofia | ||
| FT | Krumovgrad | 1-2 (0-0) | Septemvri Sofia | ||
| FT | Lokomotiv Plovdiv | 0-1 (0-1) | CSKA 1948 | ||
| FT | PFC Lokomotiv Sofia 1929 | 3-0 (0-0) | Hebar |
| FT | Cremonese | 3-0 (1-0) | Juve Stabia | ||
| FT | Spezia | 2-1 (1-1) | Catanzaro |
| FT | Hamarkameratene | 2-1 (1-1) | Molde | ||
| FT | Kristiansund BK | 0-1 (0-0) | Viking | ||
| FT | Sandefjord | 3-2 (2-0) | Stroemsgodset | ||
| FT | Sarpsborg 08 | 0-1 (0-0) | Tromsoe | ||
| FT | FK Haugesund | 0-2 (0-0) | Brann |
| FT | FK Radnicki 1923 | 5-2 (2-0) | TSC Backa Topola | ||
| FT | OFK Beograd | 2-3 (1-1) | Novi Pazar | ||
| FT | Partizan Beograd | 3-2 (2-0) | Vojvodina |
| FT | FC Gagra | 3-0 (0-0) | FC Telavi | ||
| FT | FC Samgurali Tskhaltubo | 3-0 (2-0) | Dinamo Batumi | ||
| FT | FC Gareji 1960 | 1-1 (0-1) | Iberia 1999 |
| FT | FC Minsk | 1-2 (1-1) | Maxline Vitebsk | ||
| FT | FK Molodechno | 0-1 (0-1) | FK Slutsk | ||
| FT | Gomel | 0-1 (0-0) | Dinamo Minsk |
| FT | Club Brugge | 1-1 (1-1) | Royal Antwerp | ||
| FT | RC Genk | 2-1 (1-1) | Anderlecht | ||
| FT | Union St.Gilloise | 3-1 (1-1) | La Gantoise |
| FT | Burgos CF | 2-3 (2-1) | Levante | ||
| FT | CD Mirandes | 0-0 (0-0) | Almeria | ||
| FT | Cadiz | 4-0 (4-0) | SD Huesca | ||
| FT | Eibar | 4-1 (1-0) | Cordoba | ||
| FT | Elche | 2-0 (0-0) | Malaga | ||
| FT | Eldense | 3-3 (1-1) | Racing Santander | ||
| FT | Granada CF | 2-1 (1-0) | Castellon | ||
| FT | Saragosse | 1-0 (0-0) | Deportivo La Coruna | ||
| FT | Sporting Gijon | 3-2 (1-1) | Cartagena | ||
| FT | Tenerife | 0-1 (0-0) | Real Oviedo |
| AP | Benfica | AP 1-3 | Sporting CP |
| FT | AZ Alkmaar | 3-2 (1-2) | FC Twente |
| FT | Zalgiris Vilnius | 1-1 (0-1) | Dainava Alytus | ||
| FT | Dziugas Telsiai | 1-1 (0-1) | Suduva |
| FT | ES Mostaganem | 1-0 (1-0) | ASO Chlef | ||
| FT | ES Setif | 0-1 (0-1) | USM Khenchela | ||
| FT | NC Magra | 1-3 (1-1) | JS Kabylie |
| FT | Besiktas | 1-2 (0-0) | Çaykur Rizespor | ||
| FT | Istanbul Basaksehir | 2-3 (2-1) | Adana Demirspor | ||
| FT | Kayserispor | 1-1 (0-1) | Bodrum FK | ||
| FT | Konyaspor | 1-2 (0-2) | Alanyaspor | ||
| FT | Trabzonspor | 2-2 (0-1) | Samsunspor |
| FT | KuPS | 0-2 (0-1) | VPS | ||
| FT | SJK | 0-1 (0-1) | FC Inter Turku |
| FT | Turan Tovuz | 4-0 (4-0) | FC Kapaz | ||
| FT | Araz PFK | 0-1 (0-0) | Zira |
| FT | Maribor | 0-1 (0-1) | Nafta | ||
| FT | NK Celje | 1-1 (0-1) | Domzale | ||
| FT | Mura | 1-3 (1-2) | Koper |
| FT | Clermont Foot | 1-2 (0-0) | Boulogne |
| FT | AGF | 2-3 (2-2) | Broendby IF | ||
| FT | FC Koebenhavn | 3-0 (1-0) | FC Nordsjaelland | ||
| FT | FC Midtjylland | 3-2 (1-1) | Randers FC |
| FT | BFC Daugavpils | 1-0 (1-0) | FK Jelgava | ||
| FT | FK Tukums 2000 | 2-5 (0-3) | RFS |
| FT | Veres Rivne | 1-1 (0-0) | LNZ Cherkasy | ||
| FT | Karpaty | 1-3 (1-1) | Zorya | ||
| FT | Polissya Zhytomyr | 1-1 (0-1) | Kryvbas |
| FT | AFC Bournemouth | 2-0 (0-0) | Leicester City | ||
| FT | Fulham | 0-2 (0-1) | Manchester City | ||
| FT | Ipswich Town | 1-3 (0-1) | West Ham United | ||
| FT | Liverpool | 1-1 (0-1) | Crystal Palace | ||
| FT | Manchester United | 2-0 (0-0) | Aston Villa | ||
| FT | Newcastle United | 0-1 (0-0) | Everton | ||
| FT | Nottingham | 0-1 (0-0) | Chelsea | ||
| FT | Southampton | 1-2 (0-1) | Arsenal | ||
| FT | Tottenham Hotspur | 1-4 (1-0) | Brighton & Hove Albion | ||
| FT | Wolverhampton Wanderers | 1-1 (0-1) | Brentford |
| FT | Dinamo Zagreb | 1-0 (1-0) | NK Varazdin | ||
| FT | Osijek | 1-1 (0-1) | NK Istra 1961 | ||
| FT | Rijeka | 2-0 (1-0) | Slaven | ||
| FT | Sibenik | 0-1 (0-0) | Hajduk Split |
| FT | Halmstads BK | 1-4 (1-2) | Elfsborg | ||
| FT | IFK Göteborg | 1-0 (0-0) | Malmoe FF | ||
| FT | Brommapojkarna | 0-1 (0-1) | AIK | ||
| FT | Djurgaarden | 1-1 (0-0) | Haecken |
| FT | Drita | 4-1 (2-1) | Feronikeli | ||
| FT | FC Prishtina | 2-2 (0-2) | Malisheva | ||
| FT | Ferizaj | 2-2 (1-0) | Gjilani | ||
| FT | Llapi | 3-1 (2-0) | Dukagjini | ||
| FT | Suhareka | 2-2 (1-1) | Ballkani |
| FT | Dukla Praha | 2-1 (2-1) | SK Dynamo Ceske Budejovice | ||
| FT | Mlada Boleslav | 2-2 (0-0) | Slovacko | ||
| FT | Teplice | 3-0 (1-0) | Pardubice |
| FT | CS Fola Esch | 1-4 (0-2) | FC Victoria Rosport | ||
| FT | F91 Dudelange | 5-0 (1-0) | SC Bettembourg | ||
| FT | FC Progres Niederkorn | 7-2 (3-1) | FC Mondercange | ||
| FT | FC Wiltz 71 | 2-2 (0-0) | US Hostert | ||
| FT | Racing FC Union Luxembourg | 2-0 (0-0) | FC Rodange 91 | ||
| FT | US Mondorf les Bains | 4-1 (2-1) | AS Jeunesse Esch | ||
| FT | Una Strassen | 1-0 (0-0) | FC Differdange 03 | ||
| FT | Union Titus Petange | 0-3 (0-0) | Swift Hesperange |
| FT | Borac Banja Luka | 1-0 (0-0) | Posusje | ||
| FT | FK Sarajevo | 1-1 (1-1) | Radnik Bijeljina | ||
| FT | Sloga Doboj | 0-1 (0-1) | Siroki Brijeg | ||
| FT | Zeljeznicar | 2-1 (1-0) | FK Velez Mostar | ||
| FT | Zrinjski Mostar | 3-0 (1-0) | Igman Konjic |
| FT | Simba SC | 1-1 (1-0) | RSB Berkane |
| FT | Nyiregyhaza Spartacus FC | 0-0 (0-0) | Zalaegerszegi TE |
| FT | CSM Politehnica Iasi | 1-1 (1-0) | FC Metaloglobus Bucuresti |
| FT | Hradec Kralove | 2-0 (1-0) | Bohemians 1905 |
| FT | Dalian Kuncheng | 1-0 (0-0) | Foshan Nanshi | ||
| FT | Shanghai Jiading | 2-4 (0-3) | Shaanxi Union | ||
| FT | Suzhou Dongwu | 1-1 (0-0) | Liaoning Tieren | ||
| FT | Chongqing Tongliang Long | 0-0 (0-0) | Guangxi Pingguo | ||
| FT | Shijiazhuang Gongfu | 2-0 (1-0) | Nanjing City FC |
| FT | Kazakhstan | 3-1 (2-1) | Kyrgyzstan |
| FT | Chungnam Asan FC | 2-2 (2-1) | Bucheon FC 1995 | ||
| FT | Incheon United | 2-0 (1-0) | Jeonnam Dragons | ||
| FT | Suwon Samsung Bluewings | 1-1 (0-1) | Gimpo FC |
| FT | Gwangju FC | 0-1 (0-0) | Gangwon FC |
| FT | Fagiano Okayama FC | 2-2 (1-0) | Machida Zelvia | ||
| FT | Albirex Niigata | 2-1 (1-1) | Shonan Bellmare | ||
| FT | Shimizu S-Pulse | 3-2 (2-0) | Vissel Kobe | ||
| FT | Yokohama F.Marinos | 3-1 (3-1) | Kashima Antlers | ||
| FT | Yokohama FC | 1-1 (1-1) | Kashiwa Reysol | ||
| FT | FC Tokyo | 0-3 (0-0) | Sanfrecce Hiroshima | ||
| FT | Tokyo Verdy | 1-0 (0-0) | Kyoto Sanga FC | ||
| FT | Kawasaki Frontale | 2-2 (1-0) | Gamba Osaka |
