| FT | Cerezo Osaka | 2-0 (0-0) | Avispa Fukuoka | ||
| FT | Nagoya Grampus | 2-1 (0-0) | Urawa Red Diamonds | ||
| FT | Fagiano Okayama FC | 2-2 (1-0) | Machida Zelvia | ||
| FT | Albirex Niigata | 2-1 (1-1) | Shonan Bellmare | ||
| FT | Shimizu S-Pulse | 3-2 (2-0) | Vissel Kobe | ||
| FT | Yokohama F.Marinos | 3-1 (3-1) | Kashima Antlers | ||
| FT | Yokohama FC | 1-1 (1-1) | Kashiwa Reysol |
| FT | Seattle Sounders FC | 1-0 (0-0) | FC Dallas | ||
| FT | San Diego FC | 2-1 (1-1) | LA Galaxy | ||
| FT | CF Montreal | 2-2 (2-1) | Los Angeles FC | ||
| FT | Charlotte FC | 3-2 (2-1) | Columbus Crew | ||
| FT | DC United | 0-2 (0-1) | New York Red Bulls | ||
| FT | Orlando City | 1-0 (1-0) | Portland Timbers | ||
| FT | Philadelphia Union | 3-3 (2-0) | Inter Miami CF | ||
| FT | Toronto FC | 1-2 (0-0) | Nashville SC | ||
| FT | Minnesota United | 1-1 (1-1) | Austin FC | ||
| FT | Sporting Kansas City | 3-3 (0-2) | New England Revolution | ||
| FT | Colorado Rapids | 1-0 (1-0) | St. Louis City | ||
| FT | Real Salt Lake | 2-3 (2-2) | Vancouver Whitecaps | ||
| FT | San Jose Earthquakes | 3-3 (0-1) | Houston Dynamo FC |
| FT | Fluminense | 2-1 (1-1) | Vasco da Gama | ||
| FT | Sao Paulo | 0-2 (0-0) | Mirassol | ||
| FT | Atletico MG | 0-0 (0-0) | Corinthians |
| FT | Barcelona SC | 0-0 (0-0) | Deportivo Cuenca | ||
| FT | Manta | 2-2 (1-2) | Vinotinto del Ecuador | ||
| FT | Universidad Catolica | 3-1 (0-0) | LDU de Quito | ||
| FT | Orense | 2-1 (2-0) | Aucas |
| FT | Everton CD | 2-2 (0-2) | Cobresal | ||
| FT | Colo Colo | 4-1 (3-1) | Union Espanola | ||
| FT | Coquimbo Unido | 0-0 (0-0) | Palestino |
| FT | Anguilla | 2-4 (0-3) | St. Kitts and Nevis |
| FT | Cerro Porteno | 1-1 (0-0) | 2 de Mayo | ||
| FT | Guarani | 2-1 (1-0) | Luqueno | ||
| FT | Libertad | 1-0 (0-0) | General Caballero JLM |
| Pen. | Independiente | 0-0(0-0) | Huracan* |
| FT | Envigado | 1-2 (0-0) | Llaneros FC | ||
| FT | Fortaleza FC | 0-1 (0-0) | Union Magdalena |
| FT | KA Akureyri | 1-0 (0-0) | Afturelding | ||
| FT | Valur | 3-0 (3-0) | IBV Vestmannaeyjar | ||
| FT | Vestri | 3-1 (0-1) | Stjarnan | ||
| FT | Vikingur Reykjavik | 2-1 (2-1) | IA Akranes |
| FT | Paris St-Germain | 3-0 (3-0) | Reims |
| FT | Real Madrid | 2-0 (1-0) | Real Sociedad | ||
| FT | Espanyol | 2-0 (0-0) | Las Palmas | ||
| FT | Leganes | 3-0 (3-0) | Real Valladolid | ||
| FT | Deportivo Alaves | 1-1 (0-0) | Osasuna | ||
| FT | Getafe | 1-2 (1-1) | Celta Vigo | ||
| FT | Rayo Vallecano | 0-0 (0-0) | Mallorca |
| FT | AVS Futebol SAD | 3-0 (0-0) | Vizela |
| FT | Bologna | 1-3 (0-3) | Genoa | ||
| FT | AC Milan | 2-0 (0-0) | Monza |
| Pen. | *Willem II | 3-2(3-2) | FC Dordrecht |
| FT | CF Os Belenenses | 2-1 (0-0) | Pacos de Ferreira |
| FT | FCV Dender EH | 2-2 (2-2) | KV Mechelen | ||
| FT | Sporting Charleroi | 2-1 (1-1) | OH Leuven | ||
| FT | Westerlo | 0-0 (0-0) | Standard Liege |
| FT | Universitatea Cluj | 2-2 (2-1) | Rapid Bucuresti | ||
| FT | Universitatea Craiova | 2-1 (0-1) | Dinamo Bucarest |
| FT | Arminia Bielefeld | 2-4 (0-3) | VfB Stuttgart |
| FT | MTK Budapest | 1-3 (1-2) | Ujpest | ||
| FT | Videoton FC Fehervar | 0-3 (0-1) | Debreceni VSC | ||
| FT | Gyori ETO | 1-2 (0-1) | Ferencvarosi TC | ||
| FT | Puskas FC Academy | 4-3 (1-1) | Diosgyori VTK |
| FT | Hapoel Beer Sheva | 5-0 (2-0) | Hapoel Haifa | ||
| FT | Maccabi Netanya | 2-3 (2-1) | Maccabi Haifa | ||
| FT | Maccabi Tel Aviv | 5-0 (2-0) | Beitar Jerusalem |
| FT | HNK Gorica | 0-3 (0-1) | NK Lokomotiva |
| FT | FK Crvena Zvezda | 3-1 (2-0) | Mladost Lucani |
| FT | Kolkheti-1913 Poti | 1-2 (1-1) | Dila Gori | ||
| FT | Dinamo Tbilisi | 2-0 (1-0) | Torpedo Kutaisi |
| FT | Albacete | 2-0 (1-0) | Racing de Ferrol |
| FT | FC Bâle | 4-0 (2-0) | FC Lucerne | ||
| FT | Lugano | 1-1 (0-0) | Young Boys | ||
| FT | Servette | 3-3 (1-0) | Lausanne |
| FT | FF Jaro | 1-1 (1-1) | IF Gnistan | ||
| FT | Ilves | 0-0 (0-0) | AC Oulu | ||
| FT | IFK Mariehamn | 0-4 (0-1) | HJK |
| FT | Riteriai | 2-4 (2-2) | Hegelmann |
| FT | Arsenal Women | 1-0 (0-0) | FC Barcelone (F) |
| FT | Bryne | 4-3 (2-2) | Fredrikstad | ||
| FT | Bodoe/Glimt | 4-0 (3-0) | Rosenborg |
| FT | Eyupspor | 2-1 (2-0) | Antalyaspor | ||
| FT | Gaziantep FK | 2-2 (2-0) | Kasimpasa | ||
| FT | Goztepe | 0-2 (0-0) | Galatasaray |
| Pen. | *Deportivo Riestra | 2-2(2-2) | Deportivo Armenio |
| FT | IFK Vaernamo | 1-1 (1-0) | Oesters IF | ||
| FT | GAIS | 2-1 (0-0) | Sirius |
| FT | Shamakhi FK | 0-1 (0-0) | Qarabag FK | ||
| FT | Sabah FK | 1-0 (0-0) | FK Neftchi |
| FT | Gornik Zabrze | 1-1 (0-0) | Korona Kielce | ||
| FT | Jagiellonia Bialystok | 1-1 (0-1) | Pogon Szczecin | ||
| FT | Lech Poznan | 1-0 (1-0) | Piast Gliwice | ||
| FT | Lechia Gdansk | 2-3 (1-1) | GKS Katowice | ||
| FT | Legia Warszawa | 2-2 (0-0) | Stal Mielec | ||
| FT | Puszcza Niepolomice | 1-1 (1-0) | Slask Wroclaw | ||
| FT | Radomiak Radom | 2-3 (0-1) | Motor Lublin | ||
| FT | Rakow Czestochowa | 2-1 (1-0) | Widzew Lodz | ||
| FT | Zaglebie Lubin | 1-2 (0-2) | Cracovia |
| FT | Trencin | 4-2 (1-1) | Zlate Moravce |
| FT | FK IMT Beograd | 2-1 (0-1) | Napredak | ||
| FT | FK Spartak Subotica | 2-4 (1-3) | Tekstilac Odzaci | ||
| FT | Radnicki Nis | 3-1 (2-0) | Jedinstvo Ub |
| FT | Austria Wien | 2-2 (1-0) | BW Linz | ||
| FT | Red Bull Salzbourg | 4-2 (3-1) | Rapid Vienne | ||
| FT | Sturm Graz | 1-1 (1-0) | Wolfsberger AC |
| FT | FS Metta/LU | 0-3 (0-2) | Riga FC | ||
| FT | FK Liepaja | 0-0 (0-0) | Auda |
| FT | Chornomorets Odesa | 0-0 (0-0) | FC Oleksandriya | ||
| FT | Rukh Lviv | 1-1 (0-0) | Shakhtar Donetsk | ||
| FT | Dynamo Kyiv | 1-1 (1-0) | FC Kolos Kovalivka |
| FT | Sheffield United | 1-2 (1-0) | Sunderland |
| Pen. | *Aberdeen | 1-1(1-1) | Celtic |
| FT | Slavia Prague | 3-0 (2-0) | Banik Ostrava | ||
| FT | Sparta Prague | 1-1 (0-0) | Sigma Olomouc | ||
| FT | Viktoria Plzen | 4-1 (3-0) | Jablonec |
| FT | Akron Togliatti | 1-4 (0-1) | Lokomotiv Moscow | ||
| FT | CSKA Moscow | 2-0 (1-0) | Nizhny Novgorod | ||
| FT | Dynamo Makhachkala | 1-1 (1-0) | FC Rostov | ||
| FT | FC Krasnodar | 3-0 (0-0) | Dinamo Moscow | ||
| FT | Fakel | 1-1 (0-1) | Krylya Sovetov Samara | ||
| FT | Rubin Kazan | 4-2 (3-2) | FC Orenburg | ||
| FT | Spartak Moscow | 5-0 (2-0) | Khimki | ||
| FT | Zenit St. Petersburg | 3-0 (2-0) | FK Akhmat |
| FT | Lyngby | 3-1 (1-0) | AaB | ||
| FT | Silkeborg | 1-2 (1-2) | Viborg | ||
| FT | Vejle Boldklub | 2-3 (0-0) | Soenderjyske Fodbold |
| FT | Mamelodi Sundowns FC | 1-1 (0-0) | Pyramids FC |
| FT | NK Bravo | 0-0 (0-0) | Olimpija Ljubljana |
| FT | Cheongju FC | 0-0 (0-0) | Ansan Greeners | ||
| FT | Hwaseong FC | 0-1 (0-1) | Seoul E-Land FC | ||
| FT | Gyeongnam FC | 3-1 (3-1) | Cheonan City | ||
| FT | Seongnam FC | 0-0 (0-0) | Busan I'Park |
| FT | FC Seoul | 1-1 (1-0) | Suwon FC | ||
| FT | Daejeon Hana Citizen | 2-1 (1-0) | Daegu FC | ||
| FT | Ulsan HD FC | 3-2 (0-1) | Gimcheon Sangmu |
| FT | Auckland FC | 0-2 (0-0) | Melbourne Victory | ||
| FT | Melbourne City FC | 1-1 (1-0) | Western United FC |
