| FT | CF America | 0-0 (0-0) | Toluca |
| Pen. | Fortaleza | 1-1(1-1) | Retro FC* | ||
| FT | Aparecidense | 1-4 (1-2) | Fluminense | ||
| FT | Bahia | 4-0 (3-0) | Paysandu | ||
| FT | Atletico MG | 4-0 (1-0) | Maringa FC | ||
| FT | Corinthians | 1-0 (0-0) | Novorizontino | ||
| FT | Flamengo | 4-2 (3-1) | Botafogo PB | ||
| FT | Maracana EC | 0-3 (0-0) | Internacional | ||
| FT | Vila Nova | 0-3 (0-0) | Cruzeiro | ||
| FT | Palmeiras | 3-0 (0-0) | Ceara | ||
| Pen. | *CRB | 0-0(0-0) | Santos FC | ||
| FT | Capital FC | 1-0 (1-0) | Botafogo RJ | ||
| FT | Red Bull Bragantino | 6-0 (2-0) | Criciuma |
| FT | Lanus | 2-0 (2-0) | Velez Sarsfield | ||
| FT | Defensa y Justicia | 0-2 (0-1) | Newell's Old Boys |
| FT | AZ Alkmaar | 4-1 (3-0) | SC Heerenveen | ||
| AP | FC Twente | AP 3-2 | NEC Nijmegen |
| FT | Livingston | 1-1 (1-0) | Ross County |
| FT | FC Heidenheim | 2-2 (0-2) | Elversberg |
| FT | Grasshopper Zurich | 2-0 (1-0) | Saint-Gall | ||
| FT | Winterthur | 2-0 (2-0) | Sion | ||
| FT | Yverdon | 3-2 (1-0) | FC Zürich |
| FT | Al Akhdoud | 1-0 (0-0) | Al-Raed | ||
| FT | Damac FC | 0-1 (0-0) | Al Fateh FC | ||
| FT | Al Ahli | 1-3 (1-0) | Al-Ettifaq |
| FT | Levadiakos | 3-2 (1-1) | NFC Volos | ||
| FT | Panetolikos | 1-0 (1-0) | Panserraikos FC | ||
| FT | Athens Kallithea FC | 3-0 (1-0) | Lamia |
| FT | Hammarby | 1-2 (1-1) | Mjaellby | ||
| FT | Malmoe FF | 0-0 (0-0) | AIK |
| FT | CS Constantine | 2-2 (2-0) | MC Oran |
| FT | Blumenthaler SV | 4-6 (2-3) | Werder Bremen |
| FT | Atletico Tembetary | 1-2 (0-1) | Guarani | ||
| FT | Olimpia | 1-1 (0-1) | Libertad | ||
| FT | Sportivo Ameliano | 0-0 (0-0) | Cerro Porteno |
