| Pen. | *Vasco da Gama | 1-1(1-1) | Operario Ferroviario | ||
| FT | Athletico Paranaense | 1-0 (1-0) | Brusque | ||
| FT | Gremio | 0-0 (0-0) | CS Alagoano | ||
| FT | Nautico | 1-2 (0-1) | Sao Paulo |
| Pen. | Argentinos Juniors | 1-1(1-1) | San Lorenzo* | ||
| FT | Boca Juniors | 0-1 (0-0) | Independiente | ||
| Pen. | River Plate | 1-1(1-1) | Club Atletico Platense* |
| FT | St. Kitts and Nevis | 1-3 (1-1) | Saint Vincent and The Grenadines |
| FT | Luqueno | 0-0 (0-0) | Recoleta | ||
| FT | Sportivo Trinidense | 2-0 (0-0) | Nacional |
| FT | Crystal Palace | 4-2 (2-1) | Wolverhampton Wanderers | ||
| FT | Manchester City | 3-1 (2-0) | AFC Bournemouth |
| FT | Boulogne | 1-3 (1-1) | Clermont Foot |
| FT | FC Den Bosch | 0-0 (0-0) | Telstar |
| FT | DAC 1904 Dunajska Streda | 2-1 (1-1) | Zemplin Michalovce | ||
| Pen. | FC Kosice | 2-2(2-2) | Zeleziarne Podbrezova* |
| FT | Zlate Moravce | 1-1 (1-0) | Trencin |
| FT | Al Qadsiah | 3-1 (0-0) | Al-Orobah FC | ||
| FT | Al-Taawoun | 3-2 (1-2) | Al Riyadh | ||
| FT | Al Shabab | 2-3 (1-2) | Al Ittihad |
| FT | Hebar | 1-0 (1-0) | Botev Vratsa | ||
| FT | Septemvri Sofia | 0-2 (0-2) | PFC Lokomotiv Sofia 1929 |
| FT | Naftan Novopolotsk | 1-3 (1-3) | Neman Grodno | ||
| FT | Slavia Mozyr | 1-0 (0-0) | Torpedo Zhodino |
| FT | Auda | 1-1 (1-0) | BFC Daugavpils | ||
| FT | RFS | 2-0 (1-0) | FS Metta/LU |
| FT | Dila Gori | 4-3 (2-2) | FC Samgurali Tskhaltubo | ||
| FT | Iberia 1999 | 1-0 (0-0) | Dinamo Tbilisi | ||
| FT | Torpedo Kutaisi | 2-1 (1-1) | Kolkheti-1913 Poti |
| FT | HJK | 4-2 (3-0) | SJK |
| FT | Guangzhou Dandelion Alpha | 0-1 (0-1) | Zhejiang Professional | ||
| FT | Shaanxi Union | 2-1 (0-1) | Wuhan Three Towns | ||
| FT | Guangxi Hengchen | 2-1 (1-1) | Meizhou Hakka |
| FT | Llaneros FC | 1-3 (0-3) | Tolima | ||
| FT | Independiente Medellin | 2-0 (0-0) | Deportivo Pereira |
| FT | Colo Colo | 2-2 (1-2) | CD Nublense | ||
| FT | La Serena | 2-1 (1-1) | Deportes Iquique |
| FT | LDU de Quito | 1-1 (0-0) | Libertad |
