| FT | Machida Zelvia | 3-0 (3-0) | Kashiwa Reysol | ||
| FT | Sanfrecce Hiroshima | 2-1 (0-0) | Tokyo Verdy | ||
| FT | Vissel Kobe | 3-2 (0-0) | Gamba Osaka | ||
| FT | Yokohama F.Marinos | 0-3 (0-1) | Kyoto Sanga FC | ||
| FT | Avispa Fukuoka | 1-1 (0-0) | Nagoya Grampus |
| FT | Independiente Medellin | 0-1 (0-0) | Tolima | ||
| FT | Junior FC | 2-1 (1-0) | Fortaleza FC | ||
| FT | Millonarios | 1-0 (1-0) | Envigado |
| FT | Deportivo Cuenca | 2-0 (2-0) | Tecnico Universitario |
| FT | Union La Calera | 0-1 (0-0) | Coquimbo Unido |
| FT | Recoleta | 1-1 (0-0) | Atletico Tembetary | ||
| FT | Cerro Porteno | 2-1 (2-1) | General Caballero JLM |
| FT | Alverca | 2-1 (1-0) | Portimonense | ||
| FT | Maritimo | 1-2 (1-1) | Vizela | ||
| FT | Uniao de Leiria | 0-2 (0-0) | Tondela |
| FT | Aston Villa | 2-0 (0-0) | Tottenham Hotspur | ||
| FT | Chelsea | 1-0 (0-0) | Manchester United |
| FT | Lyon (F) | 3-0 (1-0) | Paris St-Germain (F) |
| FT | Livingston | 2-0 (1-0) | Partick Thistle |
| FT | OH Leuven | 0-2 (0-1) | Westerlo |
| FT | Bray Wanderers | 3-1 (2-0) | Athlone Town | ||
| FT | Cobh Ramblers | 1-2 (0-2) | Dundalk | ||
| FT | Kerry FC | 1-1 (1-0) | Wexford FC | ||
| FT | Treaty United | 4-0 (1-0) | UCD |
| FT | Bohemian FC | 1-0 (1-0) | Shelbourne | ||
| FT | Drogheda United | 1-1 (1-0) | Derry City | ||
| FT | Galway United FC | 0-1 (0-0) | Sligo Rovers | ||
| FT | St. Patrick's Athletic | 3-2 (1-0) | Cork City | ||
| FT | Waterford FC | 1-3 (1-1) | Shamrock Rovers |
| FT | Levante | 1-0 (1-0) | Albacete |
| FT | Kecskemeti TE | 0-1 (0-0) | Puskas FC Academy | ||
| FT | Ujpest | 2-2 (1-1) | Nyiregyhaza Spartacus FC |
| FT | Stal Mielec | 2-2 (1-1) | Radomiak Radom | ||
| FT | Slask Wroclaw | 1-1 (0-0) | Jagiellonia Bialystok |
| AP | Cambuur | AP 1-1 | FC Den Bosch |
| FT | Dinamo Bucarest | 1-3 (1-0) | Universitatea Cluj |
| FT | Brann | 2-2 (1-1) | Sarpsborg 08 | ||
| FT | Fredrikstad | 1-0 (1-0) | KFUM | ||
| FT | Molde | 0-1 (0-1) | Kristiansund BK | ||
| FT | Rosenborg | 1-0 (1-0) | FK Haugesund | ||
| FT | Stroemsgodset | 0-2 (0-1) | Bryne | ||
| FT | Tromsoe | 2-1 (0-1) | Bodoe/Glimt | ||
| FT | Viking | 3-1 (0-0) | Sandefjord | ||
| FT | Vaalerenga | 1-1 (1-1) | Hamarkameratene |
| FT | Al Fateh FC | 3-4 (2-0) | Al Hilal | ||
| FT | Al-Orobah FC | 1-2 (1-1) | Al Khaleej | ||
| FT | Al Nassr FC | 1-1 (0-0) | Al-Taawoun |
| FT | Famalicao | 2-1 (1-0) | Casa Pia AC | ||
| FT | Rio Ave | 1-1 (1-1) | Gil Vicente |
| FT | FC Smorgon | 0-2 (0-0) | Slavia Mozyr | ||
| FT | Torpedo Zhodino | 0-1 (0-0) | Neman Grodno | ||
| FT | Gomel | 2-0 (1-0) | Naftan Novopolotsk |
| FT | FC Nordsjaelland | 2-0 (1-0) | AGF |
| FT | IF Gnistan | 2-2 (1-1) | SJK | ||
| FT | Haka | 1-3 (0-1) | KuPS |
| FT | Dainava Alytus | 0-3 (0-1) | Suduva |
| FT | FC Gareji 1960 | 0-0 (0-0) | FC Telavi | ||
| FT | Kolkheti-1913 Poti | 2-2 (1-1) | Iberia 1999 | ||
| FT | Dinamo Batumi | 0-3 (0-1) | Dila Gori | ||
| FT | FC Gagra | 1-1 (1-1) | Dinamo Tbilisi |
| FT | SK Super Nova | 1-1 (0-1) | FK Tukums 2000 |
| FT | NK Istra 1961 | 3-0 (2-0) | Sibenik |
| FT | MC Oran | 2-1 (2-1) | NC Magra | ||
| FT | Olympique Akbou | 2-1 (1-0) | USM Khenchela |
| FT | Otelul Galati | 0-0 (0-0) | FCV Farul Constanta |
| FT | Zhejiang Professional | 2-2 (2-1) | Henan FC | ||
| FT | Yunnan Yukun | 2-0 (1-0) | Meizhou Hakka |
| FT | Dalian Kuncheng | 2-1 (1-1) | Shenzhen Juniors | ||
| FT | Guangxi Pingguo | 0-1 (0-1) | Foshan Nanshi | ||
| FT | Nanjing City FC | 2-1 (0-0) | Suzhou Dongwu |
| FT | Western United FC | 0-3 (0-1) | Melbourne City FC |
| FT | Cruz Azul | 1-0 (0-0) | CF America |
| FT | Atletico MG | 3-1 (1-0) | Caracas | ||
| FT | Cienciano | 4-0 (3-0) | Deportes Iquique |
| FT | Once Caldas | 2-1 (1-0) | GV San Jose |
| FT | Flamengo | 2-0 (1-0) | LDU de Quito |
| FT | River Plate | 6-2 (3-2) | Independiente del Valle |
