| FT | Tigres | 1-1 (1-1) | Toluca | ||
| FT | Cruz Azul | 1-0 (0-0) | CF America |
| FT | Atletico MG | 3-1 (1-0) | Caracas | ||
| FT | Cienciano | 4-0 (3-0) | Deportes Iquique |
| FT | Once Caldas | 2-1 (1-0) | GV San Jose |
| FT | Flamengo | 2-0 (1-0) | LDU de Quito |
| FT | Universitario de Deportes | 1-0 (1-0) | Barcelona SC | ||
| FT | River Plate | 6-2 (3-2) | Independiente del Valle |
| FT | Independiente Medellin | 0-1 (0-0) | Tolima |
| FT | America de Cali | 0-0 (0-0) | Huracan | ||
| FT | Racing | 0-1 (0-0) | Corinthians |
| FT | Independiente | 1-0 (1-0) | Guarani |
| FT | Palmeiras | 2-0 (2-0) | Bolivar |
| FT | Sao Paulo | 1-1 (0-0) | Libertad | ||
| FT | Talleres | 2-0 (2-0) | Alianza Lima |
| FT | Nacional | 0-2 (0-1) | Internacional |
| FT | Penafiel | 0-0 (0-0) | Chaves | ||
| FT | Mafra | 2-0 (1-0) | Torreense |
| FT | Osasuna | 2-0 (1-0) | Atletico Madrid | ||
| FT | Rayo Vallecano | 2-2 (2-0) | Real Betis | ||
| FT | Espanyol | 0-2 (0-0) | Barcelona | ||
| FT | Getafe | 0-2 (0-0) | Athletic Bilbao |
| FT | Servette | 4-1 (2-1) | Lugano | ||
| FT | Young Boys | 2-1 (1-0) | FC Lucerne |
| FT | Widzew Lodz | 0-2 (0-2) | Legia Warszawa |
| FT | Al Qadasiya | 3-1 (1-1) | Al-Wehda | ||
| FT | Al Riyadh | 1-3 (1-2) | Al Shabab | ||
| FT | Al-Raed | 1-3 (1-2) | Al Ittihad |
| FT | Krumovgrad | 0-1 (0-1) | Slavia Sofia | ||
| FT | Lokomotiv Plovdiv | 1-3 (1-1) | Botev Vratsa | ||
| FT | Septemvri Sofia | 1-0 (1-0) | Hebar |
| FT | Djurgaarden | 1-3 (1-1) | Mjaellby | ||
| FT | Elfsborg | 4-3 (2-2) | Brommapojkarna | ||
| FT | IFK Göteborg | 0-1 (0-0) | Oesters IF | ||
| FT | IFK Norrkoeping | 1-2 (0-0) | Degerfors | ||
| FT | IFK Vaernamo | 2-2 (1-2) | Malmoe FF |
| FT | ES Setif | 0-1 (0-0) | CS Constantine |
| FT | FK Jelgava | 3-1 (2-1) | Auda | ||
| FT | FS Metta/LU | 1-1 (0-1) | Grobina |
| FT | FC Samgurali Tskhaltubo | 0-1 (0-1) | Torpedo Kutaisi |
| FT | Houston Dynamo FC | 2-0 (1-0) | Minnesota United | ||
| FT | Nashville SC | 2-1 (1-0) | New York Red Bulls | ||
| FT | St. Louis City | 2-2 (2-0) | Sporting Kansas City | ||
| FT | Austin FC | 1-1 (0-0) | Atlanta United | ||
| FT | Real Salt Lake | 0-0 (0-0) | Portland Timbers | ||
| FT | Los Angeles FC | 4-0 (1-0) | Seattle Sounders FC | ||
| FT | San Diego FC | 2-0 (1-0) | Colorado Rapids | ||
| FT | San Jose Earthquakes | 3-3 (3-2) | Inter Miami CF |
| FT | Cruzeiro | 2-1 (0-1) | Palestino |
| FT | Cerro Largo | 0-1 (0-0) | Vitoria |
| FT | Racing Club | 4-0 (2-0) | Colo Colo |
| FT | Botafogo RJ | 3-2 (1-0) | Estudiantes |
