| FT | Toluca | 2-1 (1-0) | Monterrey | ||
| FT | CF America | 2-0 (2-0) | Pachuca | ||
| FT | Cruz Azul | 2-1 (1-1) | Leon | ||
| FT | Tigres | 2-2 (0-0) | Necaxa |
| FT | Fortaleza FC | 4-0 (3-0) | La Equidad | ||
| FT | Santa Fe | 2-1 (0-0) | Junior FC | ||
| FT | Alianza FC | 2-0 (2-0) | Deportivo Cali | ||
| FT | Atletico Nacional | 2-1 (2-0) | Llaneros FC | ||
| FT | Once Caldas | 2-2 (2-1) | Millonarios |
| FT | Racing Club | 0-1 (0-0) | Club Atletico Platense | ||
| Pen. | *Boca Juniors | 0-0(0-0) | Lanus | ||
| FT | Independiente | 1-0 (0-0) | Independiente Rivadavia | ||
| FT | Argentinos Juniors | 3-1 (0-0) | Instituto | ||
| FT | Huracan | 3-2 (1-0) | Deportivo Riestra |
| FT | Gremio | 1-1 (0-0) | Red Bull Bragantino | ||
| FT | Mirassol | 2-1 (0-1) | Corinthians | ||
| FT | Vitoria | 2-1 (0-1) | Vasco da Gama | ||
| FT | Flamengo | 1-0 (1-0) | Bahia | ||
| FT | Sport Recife | 0-4 (0-3) | Cruzeiro | ||
| FT | Atletico MG | 3-2 (0-0) | Fluminense | ||
| FT | Palmeiras | 1-0 (0-0) | Sao Paulo | ||
| FT | Botafogo RJ | 4-0 (2-0) | Internacional |
| FT | CSD Macara | 0-1 (0-1) | LDU de Quito | ||
| FT | Libertad | 0-1 (0-1) | Delfin | ||
| FT | Tecnico Universitario | 1-2 (0-1) | Independiente del Valle | ||
| FT | Universidad Catolica | 2-2 (0-1) | Barcelona SC | ||
| FT | Emelec | 0-1 (0-0) | Aucas |
| FT | FC Cincinnati | 2-1 (1-0) | Austin FC | ||
| FT | New York City FC | 0-1 (0-0) | CF Montreal | ||
| FT | New York Red Bulls | 7-0 (3-0) | LA Galaxy | ||
| FT | Orlando City | 3-3 (2-2) | New England Revolution | ||
| FT | Philadelphia Union | 2-2 (1-0) | Columbus Crew | ||
| FT | FC Dallas | 1-1 (0-1) | Real Salt Lake | ||
| FT | Houston Dynamo FC | 1-3 (1-1) | Seattle Sounders FC | ||
| FT | Nashville SC | 2-1 (0-0) | Charlotte FC | ||
| FT | St. Louis City | 1-2 (0-0) | San Diego FC | ||
| FT | Colorado Rapids | 0-2 (0-1) | San Jose Earthquakes | ||
| FT | Portland Timbers | 1-0 (1-0) | Sporting Kansas City | ||
| FT | Vancouver Whitecaps | 2-2 (1-2) | Los Angeles FC |
| FT | Sportivo Ameliano | 1-2 (0-1) | Recoleta | ||
| FT | Olimpia | 0-3 (0-2) | General Caballero JLM | ||
| FT | Luqueno | 1-0 (0-0) | Libertad |
| FT | Dominica | 0-0 (0-0) | Barbados |
| FT | Estrela da Amadora | 0-1 (0-0) | AVS Futebol SAD | ||
| FT | Moreirense | 2-2 (1-0) | Estoril | ||
| FT | Vitoria de Guimaraes | 1-2 (0-1) | Farense | ||
| FT | Boavista | 1-2 (1-2) | FC Porto |
| FT | KA Akureyri | 0-1 (0-1) | Breidablik | ||
| FT | Vikingur Reykjavik | 3-1 (2-1) | FH Hafnarfjordur |
| FT | CODM Meknes | 0-3 (0-1) | FUS Rabat | ||
| FT | Difaa El Jadida | 2-1 (0-1) | Ittihad Tanger | ||
| FT | Hassania Agadir | 0-3 (0-0) | FAR Rabat | ||
| FT | MAS Fes | 1-3 (0-1) | RSB Berkane | ||
| FT | MAT Tetouan | 0-3 (0-1) | Salmi | ||
| FT | Union Touarga Sport | 0-2 (0-0) | Olympic Club de Safi | ||
| FT | Wydad Casablanca | 2-0 (2-0) | Renaissance Club Zemamra |
| FT | Lyon (F) | 4-1 (2-0) | Dijon Foot | ||
| FT | Paris St-Germain (F) | 3-0 (1-0) | Paris FC (F) |
| FT | Racing Santander | 1-1 (0-1) | Real Oviedo | ||
| FT | Albacete | 3-2 (1-0) | SD Huesca | ||
| FT | Eldense | 1-0 (0-0) | Malaga | ||
| FT | Tenerife | 0-0 (0-0) | Racing de Ferrol |
| FT | Leganes | 3-2 (2-0) | Espanyol | ||
| FT | Barcelona | 4-3 (4-2) | Real Madrid | ||
| FT | Athletic Bilbao | 1-0 (0-0) | Deportivo Alaves | ||
| FT | Real Betis | 1-1 (0-0) | Osasuna |
| FT | Udinese | 1-2 (0-0) | Monza | ||
| FT | Hellas Verona | 1-1 (1-1) | Lecce | ||
| FT | Torino | 0-2 (0-1) | Inter Milan | ||
| FT | Naples | 2-2 (1-1) | Genoa |
| Pen. | *Central Cordoba de Rosario | 1-1(1-1) | Gimnasia LP |
| FT | OFK Beograd | 1-0 (0-0) | Mladost Lucani | ||
| FT | FK Crvena Zvezda | 1-1 (1-0) | Vojvodina | ||
| FT | Partizan Beograd | 1-2 (0-0) | TSC Backa Topola |
| FT | FC Nordsjaelland | 2-2 (1-1) | Broendby IF | ||
| FT | AGF | 1-3 (1-1) | Randers FC | ||
| FT | FC Koebenhavn | 1-1 (0-1) | FC Midtjylland |
| FT | ES Setif | 1-0 (0-0) | Olympique Akbou | ||
| FT | USM Alger | 2-1 (0-1) | CS Constantine |
| FT | Al Shabab | 3-1 (2-1) | Al Ahli | ||
| FT | Damac FC | 1-0 (0-0) | Al-Raed | ||
| FT | Al-Taawoun | 0-1 (0-0) | Al Qadasiya | ||
| FT | Al Ittihad | 3-0 (1-0) | Al-Fayha |
| FT | Zeljeznicar | 1-0 (0-0) | Sloga Doboj | ||
| FT | GOSK Gabela | 1-2 (0-2) | Posusje |
| FT | Hebar | 1-2 (1-0) | Lokomotiv Plovdiv | ||
| FT | Botev Vratsa | 1-0 (1-0) | Krumovgrad | ||
| FT | CSKA 1948 | 2-0 (1-0) | Septemvri Sofia |
| FT | Universitatea Cluj | 0-2 (0-0) | FCSB |
| FT | Bayer Leverkusen | 2-4 (1-2) | Borussia Dortmund | ||
| FT | Eintracht Frankfurt | 2-2 (1-2) | St. Pauli | ||
| FT | VfB Stuttgart | 4-0 (1-0) | Augsburg |
| FT | Hapoel Haifa | 1-0 (1-0) | Beitar Jerusalem |
| FT | FCV Dender EH | 5-0 (4-0) | OH Leuven |
| FT | Brann | 0-0 (0-0) | Rosenborg | ||
| FT | Bryne | 0-3 (0-3) | Molde | ||
| FT | KFUM | 1-3 (1-1) | Tromsoe | ||
| FT | Kristiansund BK | 0-1 (0-0) | Fredrikstad | ||
| FT | Sandefjord | 2-1 (1-1) | Vaalerenga | ||
| FT | Sarpsborg 08 | 4-0 (1-0) | Hamarkameratene | ||
| FT | FK Haugesund | 1-4 (0-2) | Viking |
| FT | PAOK Thessaloniki FC | 1-0 (1-0) | AEK Athens | ||
| FT | Panathinaikos | 0-1 (0-0) | Olympiacos |
| FT | Iberia 1999 | 2-1 (0-0) | FC Samgurali Tskhaltubo | ||
| FT | Torpedo Kutaisi | 1-0 (0-0) | Dinamo Batumi |
| FT | Torreense | 3-2 (1-2) | Leixoes | ||
| FT | Tondela | 1-2 (1-2) | Alverca | ||
| FT | Vizela | 1-1 (1-0) | Academico Viseu | ||
| FT | Benfica B | 1-1 (0-0) | Penafiel | ||
| FT | Portimonense | 0-3 (0-2) | FC Porto B |
| FT | La Gantoise | 0-3 (0-2) | Royal Antwerp | ||
| FT | RC Genk | 0-2 (0-1) | Club Brugge |
| FT | Akron Togliatti | 3-2 (2-1) | FK Akhmat | ||
| FT | Fakel | 0-1 (0-1) | Lokomotiv Moscow | ||
| FT | Dinamo Moscow | 2-0 (2-0) | Spartak Moscow | ||
| FT | Rubin Kazan | 1-0 (0-0) | FC Rostov |
| FT | HNK Gorica | 1-1 (0-0) | Hajduk Split | ||
| FT | NK Istra 1961 | 0-0 (0-0) | NK Varazdin |
| Pen. | *Caernarfon | 0-0(0-0) | Cardiff Met University |
| FT | AEL Limassol | 1-0 (1-0) | Karmiotissa Pano Polemidion | ||
| FT | Enosis Paralimni | 4-2 (2-2) | Ethnikos Achnas | ||
| FT | Omonia Aradippou | 4-1 (2-0) | Omonia 29 Maiou |
| FT | Silkeborg | 1-0 (0-0) | Soenderjyske Fodbold | ||
| FT | Viborg | 3-1 (0-0) | AaB |
| FT | DAC 1904 Dunajska Streda | 1-0 (1-0) | Spartak Trnava |
| FT | Zemplin Michalovce | 4-5 (2-3) | Komarno |
| FT | FK Tukums 2000 | 2-0 (0-0) | FS Metta/LU | ||
| FT | SK Super Nova | 1-1 (1-0) | Auda |
| FT | FC Kapaz | 1-0 (1-0) | Sumqayit | ||
| FT | Qarabag FK | 2-0 (1-0) | Araz PFK |
| FT | Sivasspor | 0-0 (0-0) | Bodrum FK | ||
| FT | Besiktas | 4-1 (2-1) | Adana Demirspor | ||
| FT | Goztepe | 1-1 (1-1) | Hatayspor |
| FT | Viktoria Plzen | 1-2 (0-0) | Banik Ostrava |
| FT | Domzale | 2-0 (1-0) | Nafta | ||
| FT | Maribor | 3-1 (2-0) | Primorje |
| FT | Newcastle United | 2-0 (1-0) | Chelsea | ||
| FT | Manchester United | 0-2 (0-1) | West Ham United | ||
| FT | Nottingham | 2-2 (1-1) | Leicester City | ||
| FT | Tottenham Hotspur | 0-2 (0-1) | Crystal Palace | ||
| FT | Liverpool | 2-2 (2-0) | Arsenal |
| FT | Lechia Gdansk | 3-2 (2-0) | Korona Kielce | ||
| FT | GKS Katowice | 2-1 (1-1) | Cracovia | ||
| FT | Legia Warszawa | 0-1 (0-0) | Lech Poznan |
| FT | Banga Gargzdai | 0-1 (0-1) | Suduva | ||
| FT | Dainava Alytus | 1-2 (1-1) | FA Siauliai |
| FT | FK Spartak Subotica | 1-0 (1-0) | Radnicki Nis |
| FT | Wolfsberger AC | 2-0 (1-0) | BW Linz | ||
| FT | Austria Wien | 1-2 (0-1) | Rapid Vienne |
| FT | FK Vitebsk | 4-1 (2-1) | FK Slutsk | ||
| FT | Isloch | 2-2 (0-1) | Dinamo Minsk | ||
| FT | Neman Grodno | 0-1 (0-0) | FC Smorgon |
| FT | Kryvbas | 0-1 (0-1) | FC Kolos Kovalivka | ||
| FT | Karpaty | 2-1 (0-1) | FC Oleksandriya |
| FT | PEC Zwolle | 1-1 (0-0) | Go Ahead Eagles | ||
| FT | FC Twente | 2-0 (1-0) | FC Utrecht | ||
| FT | Feyenoord | 2-3 (2-0) | PSV Eindhoven | ||
| FT | AZ Alkmaar | 3-0 (2-0) | FC Groningen | ||
| FT | Ajax Amsterdam | 0-3 (0-0) | NEC Nijmegen |
| FT | FC Lucerne | 1-1 (0-0) | Lausanne | ||
| FT | Servette | 0-0 (0-0) | Young Boys |
| FT | AIK | 2-1 (1-1) | Mjaellby | ||
| FT | Hammarby | 1-1 (1-1) | IFK Norrkoeping | ||
| FT | Degerfors | 1-4 (0-2) | Malmoe FF | ||
| FT | Oesters IF | 0-1 (0-0) | Elfsborg |
| FT | Patro Eisden | 1-1 (1-1) | KSC Lokeren |
| FT | Drita | 0-1 (0-0) | Dukagjini | ||
| FT | FC Prishtina | 1-2 (0-1) | Gjilani | ||
| FT | Ferizaj | 2-3 (1-1) | Ballkani | ||
| FT | Malisheva | 1-0 (0-0) | Feronikeli | ||
| FT | Suhareka | 4-2 (2-1) | Llapi |
| FT | FCI Levadia | 2-1 (2-0) | Paide Linnameeskond | ||
| FT | Narva Trans | 4-2 (1-1) | Parnu JK Vaprus |
| FT | F91 Dudelange | 2-3 (1-1) | FC Mondercange | ||
| FT | FC Rodange 91 | 1-1 (0-1) | US Hostert | ||
| FT | Racing FC Union Luxembourg | 2-0 (0-0) | FC Victoria Rosport | ||
| FT | US Mondorf les Bains | 4-0 (3-0) | Swift Hesperange | ||
| FT | Una Strassen | 3-0 (2-0) | SC Bettembourg |
| FT | Zalaegerszegi TE | 0-0 (0-0) | Ujpest | ||
| FT | Nyiregyhaza Spartacus FC | 1-0 (0-0) | Diosgyori VTK |
| FT | Coleraine | 0-2 (0-1) | Cliftonville |
| FT | Slovan Liberec | 1-0 (0-0) | Bohemians 1905 |
| FT | Teplice | 1-0 (0-0) | Slovacko | ||
| FT | Mlada Boleslav | 2-3 (1-1) | Dukla Praha |
| FT | FF Jaro | 0-3 (0-0) | HJK |
| FT | Changchun Yatai | 0-1 (0-0) | Henan FC | ||
| FT | Tianjin Jinmen Tiger | 0-1 (0-1) | Yunnan Yukun | ||
| FT | Wuhan Three Towns | 2-2 (0-2) | Dalian Yingbo |
| FT | Liaoning Tieren | 2-1 (1-0) | Dalian Kuncheng | ||
| FT | Yanbian Longding | 2-0 (1-0) | Shaanxi Union | ||
| FT | Qingdao Red Lions | 0-1 (0-0) | Suzhou Dongwu | ||
| FT | Foshan Nanshi | 1-3 (1-3) | Nanjing City FC |
| FT | Hannover 96 | 1-1 (0-1) | Greuther Fuerth | ||
| FT | Jahn Regensburg | 2-2 (1-2) | Karlsruher SC | ||
| FT | Kaiserslautern | 2-1 (2-1) | Darmstadt |
| FT | Rangers | 4-0 (0-0) | Aberdeen |
| FT | Cheongju FC | 0-2 (0-0) | Busan I'Park | ||
| FT | Jeonnam Dragons | 2-1 (1-0) | Seongnam FC | ||
| FT | Suwon Samsung Bluewings | 2-0 (2-0) | Cheonan City |
| FT | Jeju SK | 1-2 (0-1) | Ulsan HD FC | ||
| FT | Gangwon FC | 0-4 (0-2) | Gimcheon Sangmu | ||
| FT | Gwangju FC | 0-1 (0-1) | Jeonbuk Hyundai Motors FC |
| FT | Kashima Antlers | 2-1 (1-1) | Kawasaki Frontale | ||
| FT | Shimizu S-Pulse | 2-2 (0-1) | Machida Zelvia | ||
| FT | Kyoto Sanga FC | 1-1 (0-0) | Nagoya Grampus | ||
| FT | Albirex Niigata | 1-1 (0-0) | Urawa Red Diamonds | ||
| FT | Cerezo Osaka | 1-0 (1-0) | Yokohama F.Marinos | ||
| FT | Gamba Osaka | 0-1 (0-1) | Sanfrecce Hiroshima | ||
| FT | Tokyo Verdy | 0-2 (0-0) | Shonan Bellmare |
