| FT | Yokohama FC | 1-0 (0-0) | Avispa Fukuoka |
| FT | Millonarios | 0-0 (0-0) | Deportivo Pereira | ||
| FT | Tolima | 3-1 (2-0) | Union Magdalena | ||
| FT | Bucaramanga | 2-0 (1-0) | Independiente Medellin |
| FT | Orense | 1-0 (0-0) | Deportivo Cuenca |
| FT | Sportivo Trinidense | 2-1 (1-0) | 2 de Mayo | ||
| FT | Atletico Tembetary | 1-2 (1-2) | Nacional |
| FT | Feirense | 2-1 (0-0) | Mafra |
| FT | Coventry City | 1-2 (0-0) | Sunderland |
| FT | Las Palmas | 0-1 (0-0) | Rayo Vallecano |
| FT | Ayr United | 0-2 (0-1) | Partick Thistle |
| FT | Sporting Charleroi | 4-3 (1-2) | Westerlo |
| FT | Dundalk | 2-2 (1-1) | Bray Wanderers | ||
| FT | Finn Harps | 0-2 (0-1) | Athlone Town | ||
| FT | Kerry FC | 1-0 (1-0) | Treaty United | ||
| FT | UCD | 1-1 (1-1) | Longford Town | ||
| FT | Wexford FC | 0-2 (0-2) | Cobh Ramblers |
| FT | Cork City | 1-2 (0-1) | Derry City | ||
| FT | Shamrock Rovers | 3-0 (0-0) | Drogheda United | ||
| FT | Shelbourne | 2-1 (0-1) | St. Patrick's Athletic | ||
| FT | Waterford FC | 1-0 (1-0) | Galway United FC |
| FT | AC Milan | 3-1 (0-0) | Bologna |
| FT | Sliema Wanderers | 0-4 (0-1) | Floriana |
| FT | Cittadella | 3-1 (0-1) | Bari | ||
| FT | Cosenza | 0-1 (0-1) | Cesena | ||
| FT | Juve Stabia | 1-2 (0-2) | Reggiana | ||
| FT | Mantova | 2-1 (1-0) | Carrarese | ||
| FT | Modena | 2-2 (1-1) | Brescia | ||
| FT | Palermo | 2-0 (1-0) | Frosinone | ||
| FT | Pisa | 3-3 (1-2) | Sudtirol | ||
| FT | Sampdoria | 1-0 (1-0) | Salernitana | ||
| FT | Sassuolo | 0-2 (0-0) | Catanzaro | ||
| FT | Spezia | 2-3 (0-3) | Cremonese |
| FT | VFL Wolfsburg | 2-2 (1-1) | Hoffenheim |
| FT | Cadiz | 2-1 (0-1) | Almeria |
| FT | Motor Lublin | 1-4 (1-2) | Piast Gliwice | ||
| FT | Gornik Zabrze | 2-0 (1-0) | Slask Wroclaw |
| FT | Sloboda Tuzla | 2-2 (1-2) | Igman Konjic |
| FT | FC Gloria Buzau | 0-3 (0-1) | FC Unirea Slobozia | ||
| FT | Sepsi OSK | 2-0 (0-0) | Botosani |
| FT | Gyori ETO | 1-0 (0-0) | Videoton FC Fehervar |
| FT | Willem II | 1-2 (0-1) | Heracles |
| FT | Sturm Graz | 4-2 (2-1) | Red Bull Salzbourg |
| FT | PFK CSKA Sofia | 3-0 (2-0) | Botev Plovdiv |
| FT | Zalgiris Vilnius | 2-0 (1-0) | Riteriai | ||
| FT | Dziugas Telsiai | 0-1 (0-0) | FK Kauno Zalgiris |
| FT | Gaziantep FK | 0-1 (0-0) | Alanyaspor | ||
| FT | Istanbul Basaksehir | 1-4 (0-1) | Fenerbahce |
| FT | Ilves | 3-2 (2-1) | Haka |
| FT | Nuernberg | 1-2 (0-0) | FC Koeln | ||
| FT | Preussen Muenster | 2-0 (1-0) | Hertha Berlin |
| FT | Nea Salamis | 2-4 (0-2) | Anorthosis |
| FT | RFS | 5-1 (2-0) | BFC Daugavpils |
| FT | Harju Jalgpallikool | 0-3 (0-1) | Flora Tallinn |
| FT | Osijek | 1-1 (1-0) | NK Lokomotiva |
| FT | Sabah FK | 3-1 (1-1) | Shamakhi FK |
| FT | Zorya | 0-0 (0-0) | Shakhtar Donetsk | ||
| FT | Polissya Zhytomyr | 0-0 (0-0) | Dynamo Kyiv |
| FT | Arda Kardzhali | 1-1 (0-0) | Ludogorets Razgrad |
| FT | Shanghai Port | 3-1 (1-1) | Qingdao Hainiu |
| FT | Western United FC | 3-2 (2-1) | Adelaide United |
| FT | Necaxa | 0-0 (0-0) | Tigres | ||
| FT | Leon | 2-3 (1-3) | Cruz Azul |
| FT | Cienciano | 3-1 (1-1) | Caracas |
| FT | Barcelona SC | 2-3 (1-2) | River Plate | ||
| FT | Universitario de Deportes | 1-1 (1-1) | Independiente del Valle |
| FT | GV San Jose | 1-0 (0-0) | Fluminense |
| FT | Atletico Nacional | 3-1 (1-0) | Internacional |
