| FT | Gwangju FC | 1-0 (1-0) | Gimcheon Sangmu | ||
| FT | Ulsan HD FC | 1-1 (1-1) | Pohang Steelers | ||
| FT | Jeonbuk Hyundai Motors FC | 1-1 (0-0) | Daejeon Hana Citizen |
| FT | Avispa Fukuoka | 0-1 (0-1) | Kashima Antlers | ||
| FT | Urawa Red Diamonds | 0-1 (0-0) | Gamba Osaka | ||
| FT | Vissel Kobe | 1-3 (1-1) | Cerezo Osaka |
| FT | Aguilas Doradas | 3-3 (2-2) | Deportivo Pereira | ||
| FT | Chico FC | 1-0 (0-0) | Envigado |
| FT | Aucas | 2-0 (1-0) | Libertad |
| FT | Red Bull Bragantino | 1-0 (0-0) | Mirassol | ||
| FT | Juventude | 0-1 (0-1) | Atletico MG |
| FT | General Caballero JLM | 1-1 (1-1) | Sportivo Trinidense |
| FT | Afturelding | 3-0 (1-0) | Stjarnan | ||
| FT | Breidablik | 3-3 (0-0) | KR Reykjavik | ||
| FT | Vikingur Reykjavik | 3-2 (2-1) | Fram Reykjavik |
| FT | Rio Ave | 2-0 (0-0) | Estrela da Amadora | ||
| FT | AVS Futebol SAD | 1-2 (0-0) | Boavista |
| FT | Girona | 1-0 (1-0) | Mallorca |
| FT | Crystal Palace | 1-1 (0-0) | Nottingham |
| FT | Drogheda United | 3-2 (1-1) | Cork City | ||
| FT | Galway United FC | 1-2 (1-0) | Bohemian FC | ||
| FT | Shelbourne | 0-1 (0-1) | Waterford FC | ||
| FT | Shamrock Rovers | 2-0 (2-0) | Sligo Rovers | ||
| FT | Derry City | 1-0 (0-0) | St. Patrick's Athletic |
| FT | Genoa | 1-2 (0-0) | AC Milan |
| FT | Castellon | 4-3 (2-1) | Sporting Gijon |
| FT | Maccabi Tel Aviv | 1-1 (1-1) | Hapoel Beer Sheva |
| FT | FCSB | 3-1 (3-0) | Dinamo Bucarest |
| Pen. | Floriana | 0-0(0-0) | Hamrun Spartans* |
| FT | Malmoe FF | 1-2 (0-0) | Brommapojkarna | ||
| FT | Elfsborg | 2-0 (1-0) | GAIS |
| FT | Soenderjyske Fodbold | 2-2 (1-0) | AaB |
| FT | Athens Kallithea FC | 0-0 (0-0) | Panetolikos | ||
| FT | Panserraikos FC | 3-0 (1-0) | NFC Volos | ||
| FT | Lamia | 2-3 (1-3) | Levadiakos |
| FT | Kasimpasa | 1-1 (1-0) | Trabzonspor |
| FT | Penafiel | 0-1 (0-1) | Torreense |
| FT | Korona Kielce | 2-1 (1-0) | GKS Katowice |
| FT | Anorthosis | 1-2 (1-1) | Enosis Paralimni | ||
| FT | Karmiotissa Pano Polemidion | 1-0 (0-0) | Omonia Aradippou | ||
| FT | Omonia 29 Maiou | 0-1 (0-0) | Nea Salamis |
| FT | Krylya Sovetov Samara | 1-3 (1-1) | Dinamo Moscow |
| FT | UTA Arad | 2-0 (0-0) | Petrolul Ploiesti |
| FT | FK Jelgava | 2-2 (0-0) | RFS | ||
| FT | Auda | 1-3 (0-3) | Riga FC |
| FT | Dalian Yingbo | 0-2 (0-2) | Beijing Guoan | ||
| FT | Henan FC | 3-4 (2-2) | Tianjin Jinmen Tiger | ||
| FT | Wuhan Three Towns | 0-2 (0-2) | Shanghai Port | ||
| FT | Chengdu Rongcheng FC | 2-1 (1-0) | Zhejiang Professional | ||
| FT | Qingdao Hainiu | 3-0 (0-0) | Changchun Yatai | ||
| FT | Yunnan Yukun | 3-2 (0-2) | Shandong Taishan |
| FT | Monterrey | 2-0 (0-0) | Club Universidad Nacional |
| FT | CD Nublense | 1-1 (0-0) | Union La Calera |
