| Pen. | Los Angeles FC | 2-2(2-2) | Vancouver Whitecaps* |
| FT | Fortaleza FC | 2-1 (1-0) | Deportivo Cali | ||
| FT | Aguilas Doradas | 3-2 (0-0) | Patriotas | ||
| FT | Atletico Nacional | 0-1 (0-1) | Internacional de Bogota |
| FT | Monterrey | 0-2 (0-0) | Austin FC |
| FT | Minnesota United | 1-0 (1-0) | Necaxa |
| FT | Sao Paulo | 2-0 (0-0) | Goias | ||
| FT | Botafogo RJ | 1-1 (1-1) | Bahia |
| FT | Estrela da Amadora | 3-1 (1-1) | Brentford | ||
| FT | Millwall | 0-1 (0-1) | Colchester United | ||
| FT | Sparta Rotterdam | 4-1 (3-1) | Lamia | ||
| FT | Besiktas | 2-1 (1-1) | Sakaryaspor | ||
| FT | Nk Brinje Grosuplje | 1-1 (0-0) | Konyaspor | ||
| FT | Hoffenheim | 2-2 (2-0) | Norwich City | ||
| FT | VFL Bochum | 1-3 (1-1) | Spezia | ||
| FT | Deportivo Alaves | 2-1 (0-0) | Tenerife | ||
| FT | Cagliari | 2-0 (1-0) | Catanzaro | ||
| FT | Lille | 3-1 (3-1) | Celta Vigo | ||
| FT | NAC Breda | 1-2 (0-2) | Aris Thessaloniki FC | ||
| FT | Bristol Rovers | 2-1 (2-0) | Plymouth Argyle | ||
| FT | Bolton Wanderers | 0-1 (0-1) | Stoke City | ||
| FT | Bradford City | 2-1 (2-0) | Sunderland | ||
| FT | Famalicao | 2-2 (1-0) | Deportivo La Coruna | ||
| FT | Milton Keynes Dons | 1-1 (0-1) | Portsmouth | ||
| FT | Salford City | 0-2 (0-1) | Preston North End | ||
| FT | Wycombe Wanderers | 3-2 (1-1) | Watford | ||
| FT | Coventry City | 3-0 (1-0) | Everton | ||
| FT | Hull City | 2-2 (0-1) | Fiorentina | ||
| FT | Louisville City FC | 0-4 (0-1) | Eintracht Frankfurt | ||
| Pen. | Manchester City | 2-2(2-2) | Barcelona* |
| Pen. | *Pachuca | 1-1(1-1) | New York Red Bulls |
| FT | Atletico de San Luis | 2-3 (0-2) | CF Montreal |
| FT | Drita | 1-0 (0-0) | Breidablik | ||
| AP | Flora Tallinn | AP 5-2 | Virtus Acquaviva | ||
| FT | Pyunik | 3-1 (2-1) | FK Struga | ||
| FT | Hamrun Spartans | 0-2 (0-0) | Ballkani | ||
| FT | Decic Tuzi | 0-0 (0-0) | Dinamo Batumi |
| FT | Israel U23 | 0-1 (0-0) | Japan U23 | ||
| FT | Paraguay U23 | 1-0 (1-0) | Mali U23 |
| FT | Qarabag FK | 5-0 (3-0) | Lincoln Red Imps FC | ||
| FT | CS Petrocub | 1-1 (0-0) | APOEL Nicosia | ||
| FT | Fenerbahce | 2-1 (0-1) | Lugano | ||
| FT | Sparta Prague | 4-2 (2-1) | Shamrock Rovers | ||
| FT | TNS | 1-2 (0-1) | Ferencvarosi TC | ||
| FT | Slovan Bratislava | 5-0 (2-0) | NK Celje | ||
| FT | Klaksvik | 3-2 (1-1) | Malmoe FF |
| FT | New Zealand U23 | 0-3 (0-1) | France U23 | ||
| FT | USA U23 | 3-0 (2-0) | Guinea U23 |
| FT | Liviy Bereh | 3-0 (2-0) | FC Minaj |
| FT | Morocco U23 | 3-0 (3-0) | Iraq U23 | ||
| FT | Ukraine U23 | 0-2 (0-0) | Argentina U23 |
| FT | Dominican Republic U23 | 1-1 (0-0) | Uzbekistan U23 | ||
| FT | Spain U23 | 1-2 (0-1) | Egypt U23 |
| FT | Cobreloa | 3-1 (0-1) | Palestino |
| FT | Argentinos Juniors | 2-0 (0-0) | Lanus | ||
| FT | Belgrano | 1-0 (1-0) | Godoy Cruz |
