| FT | Real Salt Lake | 5-2 (1-1) | Atlanta United | ||
| FT | Austin FC | 2-1 (1-1) | New York City FC | ||
| FT | Seattle Sounders FC | 2-0 (1-0) | New England Revolution | ||
| FT | San Jose Earthquakes | 1-0 (0-0) | Chicago Fire FC | ||
| FT | Sporting Kansas City | 3-2 (2-1) | FC Dallas | ||
| FT | Colorado Rapids | 4-1 (2-1) | St. Louis City | ||
| FT | LA Galaxy | 2-1 (1-0) | Minnesota United | ||
| FT | Portland Timbers | 4-1 (4-0) | Nashville SC |
| FT | CD Guadalajara | 0-0 (0-0) | Toluca | ||
| FT | Tigres | 1-0 (1-0) | Necaxa | ||
| FT | Cruz Azul | 1-0 (0-0) | Mazatlan FC | ||
| FT | Club Universidad Nacional | 4-1 (2-1) | Leon | ||
| FT | Pachuca | 0-1 (0-1) | Monterrey |
| FT | Cruzeiro | 3-0 (2-0) | Corinthians | ||
| FT | Fortaleza | 1-0 (0-0) | Fluminense | ||
| FT | Juventude | 3-0 (2-0) | Gremio | ||
| FT | Internacional | 1-2 (0-0) | Vasco da Gama | ||
| FT | Atletico GO | 1-2 (0-0) | Athletico Paranaense | ||
| FT | Palmeiras | 2-0 (1-0) | Bahia | ||
| FT | Vitoria | 2-1 (2-1) | Criciuma | ||
| FT | Botafogo RJ | 3-0 (1-0) | Atletico MG |
| FT | Bodoe/Glimt | 5-1 (2-0) | Brann | ||
| FT | FK Haugesund | 1-2 (0-0) | Sarpsborg 08 | ||
| FT | Hamarkameratene | 0-0 (0-0) | Tromsoe | ||
| FT | KFUM | 1-2 (1-0) | Viking | ||
| FT | Molde | 3-0 (2-0) | Lillestroem | ||
| FT | Rosenborg | 2-1 (2-0) | Odds Ballklubb |
| FT | FC Minsk | 0-2 (0-1) | Neman Grodno | ||
| FT | Naftan Novopolotsk | 1-4 (0-1) | FK Slutsk | ||
| FT | Dnyapro Mogilev | 2-3 (1-1) | Shakhtyor Soligorsk |
| FT | Krylya Sovetov Samara | 6-0 (2-0) | Sokol Saratov | ||
| FT | Viborg | 2-0 (1-0) | Arka Gdynia | ||
| FT | FSV Hollenbach | 1-8 (0-4) | VfB Stuttgart | ||
| FT | FC Orenburg | 2-1 (0-1) | Sumqayit | ||
| FT | Union St.Gilloise | 2-2 (1-0) | Patro Eisden | ||
| FT | Almere City FC | 2-3 (0-1) | Go Ahead Eagles | ||
| FT | Rubin Kazan | 3-1 (1-0) | FC Yenisey Krasnoyarsk | ||
| FT | Novi Pazar | 0-1 (0-1) | Nizhny Novgorod | ||
| FT | CSKA Moscow | 3-0 (1-0) | Partizan Beograd |
| FT | IFK Mariehamn | 0-3 (0-2) | Haka | ||
| FT | KuPS | 3-1 (3-1) | IF Gnistan |
| FT | Suduva | 0-0 (0-0) | Dainava Alytus |
| FT | FS Metta/LU | 3-2 (2-1) | BFC Daugavpils | ||
| FT | FK Liepaja | 0-3 (0-1) | Riga FC |
| FT | AIK | 1-2 (0-1) | Kalmar FF | ||
| FT | IFK Vaernamo | 2-0 (0-0) | IFK Göteborg | ||
| FT | GAIS | 0-0 (0-0) | Hammarby | ||
| FT | Malmoe FF | 5-1 (2-1) | Halmstads BK |
| FT | Nantong Zhiyun FC | 0-1 (0-0) | Chengdu Rongcheng FC | ||
| FT | Beijing Guoan | 1-2 (0-1) | Wuhan Three Towns | ||
| FT | Qingdao Hainiu | 3-1 (3-1) | Qingdao West Coast | ||
| FT | Zhejiang Professional | 4-0 (3-0) | Meizhou Hakka |
| FT | Dalian Yingbo | 4-0 (1-0) | Qingdao Red Lions | ||
| FT | Liaoning Tieren | 2-0 (0-0) | Chongqing Tongliang Long | ||
| FT | Yanbian Longding | 0-5 (0-1) | Suzhou Dongwu |
| FT | Avispa Fukuoka | 1-2 (0-0) | Kyoto Sanga FC |
| FT | Ansan Greeners | 1-2 (0-1) | Jeonnam Dragons | ||
| FT | Cheongju FC | 2-3 (0-1) | Seoul E-Land FC |
| FT | Daejeon Hana Citizen | 2-2 (0-1) | Jeonbuk Hyundai Motors FC | ||
| FT | Gangwon FC | 2-0 (1-0) | Gwangju FC |
| Pen. | *Uruguay | 0-0(0-0) | Brésil |
