| FT | Cruz Azul | 1-1 (1-1) | CF America |
| FT | Tolima | 3-0 (2-0) | Internacional de Bogota | ||
| FT | Santa Fe | 1-0 (0-0) | Once Caldas |
| FT | Amazonas FC | 0-1 (0-0) | Flamengo | ||
| FT | Botafogo SP | 0-0 (0-0) | Palmeiras | ||
| FT | Criciuma | 0-2 (0-0) | Bahia | ||
| Pen. | Cuiaba | 1-0(1-0) | Goias* | ||
| FT | Ceara | 0-1 (0-1) | CRB | ||
| FT | Sao Paulo | 2-0 (2-0) | Aguia de Maraba |
| FT | Cerro Porteno | 2-0 (0-0) | Guarani | ||
| FT | Sportivo Trinidense | 1-1 (1-0) | General Caballero JLM |
| FT | NEC Nijmegen | 1-2 (0-0) | Go Ahead Eagles | ||
| FT | FC Utrecht | 3-1 (1-1) | Sparta Rotterdam |
| FT | Raith Rovers | 1-2 (0-0) | Ross County |
| FT | Waterford FC | 4-2 (0-1) | Drogheda United |
| FT | Cagliari | 2-3 (0-1) | Fiorentina |
| FT | VFL Bochum | 0-3 (0-1) | Fortuna Duesseldorf |
| FT | Ternana | 0-3 (0-1) | Bari |
| FT | Abha | 2-1 (1-0) | Al Khaleej | ||
| FT | Al Akhdoud | 1-1 (1-1) | Al-Wehda | ||
| FT | Al Fateh FC | 2-1 (2-1) | Al Hazem | ||
| FT | Al Hilal | 3-1 (2-0) | Al Taee | ||
| FT | Al Ittihad | 4-1 (1-0) | Damac FC | ||
| FT | Al Riyadh | 2-2 (2-1) | Al Nassr FC | ||
| FT | Al-Ettifaq | 1-0 (1-0) | Al Shabab | ||
| FT | Al-Fayha | 1-1 (1-1) | Al-Taawoun | ||
| FT | Al-Raed | 0-0 (0-0) | Al Ahli |
| FT | PFK CSKA Sofia | 0-1 (0-0) | Cherno More Varna |
| FT | Nomme United | 1-3 (0-1) | Narva Trans | ||
| FT | Parnu JK Vaprus | 1-1 (0-1) | Tammeka |
| FT | TSC Backa Topola | 6-0 (2-0) | Napredak |
| FT | Samtredia | 0-0 (0-0) | Dila Gori | ||
| FT | Iberia 1999 | 0-2 (0-2) | Kolkheti-1913 Poti | ||
| FT | Dinamo Tbilisi | 1-2 (1-0) | Dinamo Batumi |
| FT | Auda | 0-1 (0-0) | FK Jelgava |
| FT | Arda Kardzhali | 3-1 (1-1) | Slavia Sofia | ||
| FT | CSKA 1948 | 2-1 (0-0) | Botev Plovdiv |
| FT | Deportivo Pereira | 0-0 (0-0) | Junior FC |
| FT | Atletico Tucuman | 1-2 (0-0) | Gimnasia LP |
| FT | Barcelona SC | 2-0 (1-0) | LDU de Quito |
