| FT | Wellington Phoenix | 1-0 (0-0) | Melbourne Victory | ||
| FT | Adelaide United | 1-2 (1-0) | Macarthur FC | ||
| FT | Western United FC | 0-2 (0-0) | Central Coast Mariners |
| FT | Kashiwa Reysol | 1-0 (0-0) | Urawa Red Diamonds | ||
| FT | Albirex Niigata | 1-1 (0-1) | Hokkaido Consadole Sapporo | ||
| FT | Avispa Fukuoka | 1-1 (1-1) | Sanfrecce Hiroshima | ||
| FT | Jubilo Iwata | 0-1 (0-1) | Nagoya Grampus | ||
| FT | Yokohama F.Marinos | 2-2 (1-1) | Shonan Bellmare |
| FT | Gyeongnam FC | 1-1 (0-1) | Cheongju FC |
| FT | FC Seoul | 2-4 (1-1) | Pohang Steelers | ||
| FT | Jeonbuk Hyundai Motors FC | 2-1 (1-0) | Gwangju FC |
| FT | Queretaro FC | 0-2 (0-1) | Mazatlan FC | ||
| FT | Necaxa | 2-0 (1-0) | Santos Laguna | ||
| FT | Puebla | 0-1 (0-0) | Cruz Azul |
| FT | Tolima | 2-1 (2-1) | Aguilas Doradas | ||
| FT | Deportivo Cali | 1-1 (0-1) | America de Cali |
| FT | Guarani | 1-0 (0-0) | Sol de America | ||
| FT | Sportivo Trinidense | 1-2 (1-0) | 2 de Mayo |
| FT | Deportivo Cuenca | 3-3 (0-1) | Aucas |
| FT | Estudiantes | 1-0 (0-0) | Boca Juniors |
| FT | Stjarnan | 1-3 (1-1) | KR Reykjavik |
| FT | Gil Vicente | 0-4 (0-4) | Sporting CP |
| FT | Drogheda United | 2-2 (1-2) | Derry City | ||
| FT | Dundalk | 0-0 (0-0) | St. Patrick's Athletic | ||
| FT | Shelbourne | 1-2 (0-2) | Bohemian FC | ||
| FT | Waterford FC | 0-0 (0-0) | Galway United FC | ||
| FT | Shamrock Rovers | 3-0 (1-0) | Sligo Rovers |
| FT | Paris FC (F) | 2-2 (0-1) | Reims |
| FT | Metz | 2-1 (2-1) | Lens |
| FT | Real Betis | 2-1 (0-0) | Celta Vigo |
| FT | Plymouth Argyle | 1-0 (1-0) | Leicester City |
| FT | Crusaders | 1-2 (0-1) | Linfield |
| FT | St.Truiden | 3-3 (1-1) | Standard Liege |
| FT | Connah's Quay Nomads | 0-0 (0-0) | Bala Town |
| FT | Athlone Town | 1-0 (1-0) | Finn Harps | ||
| FT | Cobh Ramblers | 2-4 (0-1) | Wexford FC | ||
| FT | Treaty United | 0-0 (0-0) | Kerry FC | ||
| FT | UCD | 0-0 (0-0) | Cork City |
| FT | Lazio | 4-1 (3-1) | Salernitana |
| FT | FK Tuzla City | 3-1 (1-1) | Siroki Brijeg | ||
| FT | Borac Banja Luka | 1-0 (1-0) | Sloga Doboj |
| FT | Modena | 1-3 (1-2) | Catanzaro |
| FT | Augsburg | 2-0 (0-0) | Union Berlin |
| FT | Leganes | 0-0 (0-0) | Espanyol |
| FT | Warta Poznan | 1-0 (1-0) | Korona Kielce | ||
| FT | Pogon Szczecin | 5-0 (2-0) | Ruch Chorzow |
| FT | Excelsior | 4-0 (2-0) | FC Volendam |
| FT | Club Brugge NXT | 1-2 (0-1) | FC Liege | ||
| FT | Genk U23 | 1-1 (0-1) | Francs Borains |
| FT | Universitatea Craiova | 1-2 (1-2) | FCV Farul Constanta |
| FT | LASK | 3-1 (2-0) | Red Bull Salzbourg |
| FT | Botev Plovdiv | 2-0 (1-0) | Botev Vratsa | ||
| FT | PFK CSKA Sofia | 1-2 (1-1) | Pirin Blagoevgrad |
| FT | OB | 1-3 (1-1) | Viborg |
| FT | Dinamo Tbilisi | 0-0 (0-0) | Kolkheti-1913 Poti | ||
| FT | Dila Gori | 0-0 (0-0) | Dinamo Batumi |
| FT | Haka | 2-1 (1-0) | EIF | ||
| FT | VPS | 1-1 (0-0) | SJK | ||
| FT | FC Inter Turku | 3-3 (1-1) | AC Oulu |
| FT | Trabzonspor | 0-1 (0-0) | Sivasspor |
| FT | Greuther Fuerth | 2-1 (0-1) | Kaiserslautern | ||
| FT | Hertha Berlin | 4-0 (2-0) | Hansa Rostock |
| FT | AEL Limassol | 3-2 (3-0) | Othellos Athienou |
| FT | Santa Lucia F.C. | 0-3 (0-0) | Marsaxlokk FC |
| FT | Riga FC | 2-0 (1-0) | BFC Daugavpils | ||
| FT | RFS | 5-0 (3-0) | FK Tukums 2000 |
| FT | Zilina | 0-0 (0-0) | Ruzomberok |
| FT | Sumqayit | 0-0 (0-0) | Zira |
| FT | Rudes | 1-3 (1-0) | Slaven |
| FT | UTA Arad | 1-3 (0-1) | Hermannstadt |
| FT | FK Vitebsk | 2-0 (0-0) | FK Slutsk |
| FT | Delfin | 1-1 (0-1) | Belgrano |
| FT | Cruzeiro | 3-3 (3-0) | Alianza FC |
| FT | Coquimbo Unido | 1-0 (1-0) | Luqueno |
| FT | River Plate | 2-0 (1-0) | Nacional |
| FT | Palmeiras | 3-1 (1-1) | Liverpool FC |
