| FT | Defensa y Justicia | 0-0 (0-0) | Velez Sarsfield | ||
| FT | Argentinos Juniors | 3-0 (0-0) | Godoy Cruz |
| FT | Libertad | 1-0 (0-0) | General Caballero JLM |
| FT | VFL Wolfsburg (F) | 1-1 (1-1) | Paris St-Germain (F) | ||
| Pen. | *Chelsea (F) | 1-2(0-1) | Lyon (F) |
| FT | Queretaro FC | 2-2 (0-1) | Cruz Azul |
| FT | Tolima | 1-1 (0-1) | Millonarios |
| FT | Red Bull Bragantino | 2-3 (2-0) | Cruzeiro |
