| FT | Queretaro FC | 1-0 (1-0) | Monterrey | ||
| FT | Puebla | 2-0 (0-0) | Mazatlan FC | ||
| FT | CF America | 2-1 (0-0) | Santos Laguna | ||
| FT | Atlas | 0-0 (0-0) | Cruz Azul |
| FT | Club Atletico Platense | 1-1 (1-1) | Rosario Central | ||
| FT | Union | 1-1 (0-0) | Racing Club | ||
| FT | Patronato de Parana | 3-3 (2-2) | Defensa y Justicia | ||
| FT | Central Cordoba de Santiago | 1-2 (1-1) | Velez Sarsfield |
| FT | Audax Italiano | 0-3 (0-1) | CD Nublense | ||
| FT | O'Higgins | 1-2 (1-1) | Melipilla |
| FT | Ittihad Tanger | 0-2 (0-1) | FAR Rabat |
| FT | Faetano | 0-1 (0-0) | San Giovanni | ||
| FT | Juvenes/Dogana | 2-1 (1-0) | Domagnano |
| FT | Inter Milan | 3-1 (1-0) | FC Sheriff | ||
| FT | Shakhtar Donetsk | 0-5 (0-1) | Real Madrid |
| FT | Besiktas | 1-4 (1-3) | Sporting CP | ||
| FT | Ajax Amsterdam | 4-0 (2-0) | Borussia Dortmund |
| FT | Atletico Madrid | 2-3 (2-2) | Liverpool | ||
| FT | FC Porto | 1-0 (0-0) | AC Milan |
| FT | Club Brugge | 1-5 (0-2) | Manchester City | ||
| FT | Paris St-Germain | 3-2 (1-1) | RB Leipzig |
| FT | Cartagena | 1-0 (0-0) | Sporting Gijon | ||
| FT | SD Huesca | 0-0 (0-0) | Malaga | ||
| FT | Tenerife | 0-1 (0-0) | Eibar |
| FT | Bristol City | 1-2 (1-0) | Nottingham | ||
| FT | Derby County | 2-2 (1-0) | Luton Town | ||
| FT | Queens Park Rangers | 1-0 (0-0) | Blackburn Rovers | ||
| FT | Sheffield United | 1-2 (1-1) | Millwall | ||
| FT | Stoke City | 0-1 (0-0) | AFC Bournemouth |
| FT | Al Nassr FC | 1-2 (0-1) | Al Hilal |
| FT | Celtic | 2-0 (0-0) | Ferencvarosi TC |
| FT | Lokomotiv Plovdiv | 2-1 (1-0) | Pirin Blagoevgrad |
| FT | Cangzhou Mighty Lions F.C. | 1-3 (1-2) | Shenzhen FC | ||
| FT | Shaanxi Changan | 1-2 (0-1) | Shanghai Port | ||
| FT | Wuhan Yangtze River | 4-0 (0-0) | Qingdao FC | ||
| FT | Chengdu Rongcheng FC | 1-2 (0-1) | Shenzhen Peng City |
| FT | FC Prishtina | 2-1 (2-0) | Malisheva | ||
| FT | Feronikeli | 0-2 (0-0) | Drita | ||
| FT | Ulpiana | 0-6 (0-3) | Llapi |
| FT | Independiente del Valle | 1-1 (1-0) | Manta |
| FT | 12 de Octubre | 1-2 (1-1) | Guarani | ||
| FT | Cerro Porteno | 2-0 (0-0) | Club River Plate |
| FT | Sao Paulo | 1-0 (1-0) | Corinthians |
| FT | Envigado | 4-1 (1-1) | Aguilas Doradas |
