| FT | Puebla | 4-1 (2-1) | Toluca | ||
| FT | Mazatlan FC | 1-1 (0-0) | Tigres |
| FT | Aucas | 1-0 (1-0) | CSD Macara |
| FT | CF Montreal | 0-1 (0-0) | Toronto FC |
| FT | Rayo Vallecano | 0-1 (0-0) | Eibar | ||
| FT | FC Midtjylland | 5-1 (4-0) | Fredericia | ||
| FT | FC Nordsjaelland | 5-4 (3-2) | HB Koege | ||
| FT | Schalke 04 | 1-0 (0-0) | Aris Thessaloniki FC | ||
| FT | FC Zürich | 1-0 (0-0) | Wil | ||
| FT | Meppen | 0-0 (0-0) | Soenderjyske Fodbold | ||
| FT | Borussia Dortmund | 1-1 (1-0) | Paderborn | ||
| FT | Fenerbahce | 1-1 (1-1) | Alanyaspor | ||
| FT | Feyenoord | 0-1 (0-0) | Hamburger SV | ||
| FT | Galatasaray | 1-0 (1-0) | Istanbulspor | ||
| FT | Tottenham Hotspur | 4-1 (3-0) | Reading | ||
| FT | Borussia Dortmund | 1-3 (0-2) | VFL Bochum | ||
| FT | Vitesse Arnhem | 2-2 (1-2) | Fortuna Duesseldorf | ||
| FT | Granada CF | 0-3 (0-0) | Real Valladolid | ||
| FT | Valencia | 2-1 (0-1) | Villarreal | ||
| FT | Portimonense | 1-2 (0-0) | Sporting CP |
| FT | Lyon | 4-1 (3-1) | Dijon |
| FT | Oostende | 2-2 (2-1) | Anderlecht |
| FT | Zaglebie Lubin | 1-0 (0-0) | Warta Poznan | ||
| FT | Stal Mielec | 0-2 (0-1) | Gornik Zabrze |
| FT | Gaz Metan Medias | 2-0 (1-0) | FC Arges Pitesti | ||
| FT | UTA Arad | 0-0 (0-0) | FC Voluntari |
| FT | HNK Gorica | 3-2 (1-0) | Sibenik |
| FT | Diosgyori VTK | 1-1 (1-0) | MTK Budapest |
| FT | FC Tsarsko Selo Sofia 2015 | 0-0 (0-0) | CSKA 1948 | ||
| FT | Beroe | 6-0 (3-0) | Botev Vratsa |
| FT | RFC Seraing | 3-2 (0-2) | Deinze |
| FT | Pafos FC | 0-1 (0-0) | Anorthosis | ||
| FT | AEL Limassol | 2-1 (1-1) | Nea Salamis |
| FT | Indjija | 3-2 (1-0) | Javor | ||
| FT | FK Metalac | 0-0 (0-0) | Cukaricki |
| FT | Banik Ostrava | 2-2 (1-2) | SK Dynamo Ceske Budejovice |
| FT | EC Sao Jose | 1-0 (1-0) | Atletico GO |
