| FT | FC Seoul | 0-3 (0-1) | Pohang Steelers | ||
| FT | Gangwon FC | 2-4 (0-1) | Daegu FC |
| FT | Vissel Kobe | 1-0 (0-0) | Cerezo Osaka | ||
| FT | FC Tokyo | 1-1 (0-1) | Shonan Bellmare | ||
| FT | Hokkaido Consadole Sapporo | 1-2 (0-1) | Jubilo Iwata | ||
| FT | Matsumoto Yamaga | 0-1 (0-1) | Yokohama F.Marinos | ||
| FT | Nagoya Grampus | 0-0 (0-0) | Sagan Tosu | ||
| FT | Sanfrecce Hiroshima | 0-0 (0-0) | Kashima Antlers | ||
| FT | Shimizu S-Pulse | 1-1 (0-1) | Oita Trinita |
| FT | Puebla | 3-0 (3-0) | Necaxa | ||
| FT | Tijuana | 1-2 (0-1) | Leon |
| FT | General Diaz | 1-1 (0-1) | Sportivo San Lorenzo | ||
| FT | Sol de America | 2-2 (1-0) | Deportivo Santani |
| FT | Leixoes | 1-4 (0-2) | Santa Clara | ||
| FT | Varzim | 1-0 (0-0) | Loures |
| FT | Pescara | 1-1 (0-0) | Cremonese |
| FT | Barry Town | 3-0 (1-0) | Penybont |
| FT | Sporting Gijon | 0-2 (0-0) | Tenerife |
| FT | Levante | 2-1 (0-0) | Mallorca |
| FT | Glenavon | 1-0 (1-0) | Linfield |
| FT | Fulham | 2-1 (1-1) | Queens Park Rangers |
| FT | Paris St-Germain | 2-0 (2-0) | Lille |
| FT | Westerlo | 1-2 (1-2) | OH Leuven |
| FT | Club Brugge | 2-0 (1-0) | Oostende |
| FT | Borussia Dortmund | 3-3 (0-3) | Paderborn |
| FT | Gornik Zabrze | 2-2 (1-2) | Wisla Plock | ||
| FT | Lech Poznan | 3-0 (1-0) | Piast Gliwice |
| FT | Linlithgow Rose | 1-4 (1-2) | Falkirk |
| FT | AC Ajaccio | 1-1 (1-0) | Clermont Foot | ||
| FT | Caen | 3-3 (2-1) | Le Mans | ||
| FT | Châteauroux | 1-3 (1-0) | Lorient | ||
| FT | Grenoble | 1-1 (0-0) | Nancy | ||
| FT | Niort | 2-1 (0-0) | Rodez | ||
| FT | Orléans | 0-1 (0-1) | Valenciennes | ||
| FT | Paris FC | 2-0 (0-0) | Auxerre | ||
| FT | Troyes | 0-4 (0-2) | Chambly |
| FT | CFR 1907 Cluj | 4-0 (1-0) | Chindia Targoviste |
| FT | Difaa El Jadida | 1-0 (0-0) | Raja Beni Mellal |
| FT | Hamrun Spartans | 0-0 (0-0) | Floriana |
| FT | FC Nordsjaelland | 3-0 (0-0) | Randers FC |
| FT | Galatasaray | 0-1 (0-0) | Istanbul Basaksehir |
| FT | Erzgebirge Aue | 3-1 (2-0) | St. Pauli | ||
| FT | VFL Bochum | 1-1 (1-1) | Osnabrueck |
| FT | Zalgiris Vilnius | 5-0 (3-0) | Atlantas Klaipeda |
| FT | Shakhtar Donetsk | 4-1 (1-1) | FC Lviv |
| FT | Sparta Prague | 3-3 (1-2) | SK Dynamo Ceske Budejovice |
| FT | Partizan Beograd | 6-2 (4-2) | Javor |
| FT | Dinamo Zagreb | 1-1 (1-1) | Hajduk Split |
| FT | Abha | 3-1 (2-0) | Al Fateh FC | ||
| FT | Al Hazem | 2-3 (0-2) | Al-Raed | ||
| FT | Al Shabab | 0-1 (0-0) | Al-Fayha |
| FT | FC Tambov | 2-3 (1-2) | Lokomotiv Moscow |
| FT | Union La Calera | 0-0 (0-0) | Deportes Iquique | ||
| FT | Cobresal | 3-2 (1-0) | Union Espanola |
| FT | Arda Kardzhali | 2-0 (1-0) | Vitosha Bistritsa |
| FT | Sumqayit | 2-1 (0-1) | Qarabag FK |
| FT | Ballkani | 2-1 (2-1) | Gjilani |
| FT | Henan FC | 2-1 (1-1) | Tianjin Tianhai | ||
| FT | Shandong Taishan | 2-0 (1-0) | Chongqing Liangjiang Athletic | ||
| FT | Shanghai Shenhua | 1-2 (0-1) | Beijing Guoan | ||
| FT | Wuhan Yangtze River | 2-1 (2-0) | Guangzhou City |
| FT | Western Sydney Wanderers FC | 2-3 (1-0) | Melbourne City FC |
