| FT | Houston Dynamo FC | 1-3 (1-1) | Los Angeles FC | ||
| FT | LA Galaxy | 1-3 (1-0) | San Jose Earthquakes | ||
| FT | CF Montreal | 0-2 (0-0) | Toronto FC | ||
| FT | Orlando City | 1-0 (0-0) | Columbus Crew | ||
| FT | Chicago Fire FC | 1-2 (1-1) | FC Cincinnati | ||
| FT | Minnesota United | 1-0 (0-0) | FC Dallas | ||
| FT | Real Salt Lake | 4-0 (1-0) | Philadelphia Union | ||
| FT | Vancouver Whitecaps | 0-3 (0-1) | Sporting Kansas City | ||
| FT | Portland Timbers | 2-2 (1-1) | Colorado Rapids |
| FT | Deportivo Cuenca | 3-1 (2-1) | Mushuc Runa | ||
| FT | Fuerza Amarilla SC | 1-4 (1-1) | Emelec | ||
| FT | LDU de Quito | 1-5 (0-2) | Universidad Catolica | ||
| FT | Tecnico Universitario | 1-1 (1-0) | Independiente del Valle |
| FT | Atletico Huila | 3-2 (0-0) | La Equidad | ||
| FT | Junior FC | 1-0 (0-0) | Tolima | ||
| FT | CD Jaguares | 1-0 (0-0) | Union Magdalena | ||
| FT | Once Caldas | 1-2 (0-1) | Atletico Nacional |
| FT | Rayo Vallecano | 2-2 (1-0) | Leganes | ||
| FT | Young Boys | 0-2 (0-1) | Kriens | ||
| FT | Toulouse | 1-0 (0-0) | AC Ajaccio | ||
| FT | Varzim | 1-1 (0-0) | Moreirense | ||
| FT | Aves | 2-1 (1-1) | Tondela | ||
| FT | Pacos de Ferreira | 1-0 (1-0) | Chaves | ||
| FT | Rio Ave | 3-0 (1-0) | Boavista | ||
| FT | Brentford | 0-0 (0-0) | Dynamo Kyiv | ||
| FT | Willem II | 2-0 (1-0) | TOP Oss | ||
| FT | Sportfreunde Lotte | 1-1 (0-0) | FC Groningen | ||
| FT | Werder Bremen | 1-1 (0-1) | Darmstadt | ||
| FT | Manchester United | 2-0 (0-0) | Perth Glory | ||
| FT | FC Liefering | 2-5 (2-3) | Brighton & Hove Albion | ||
| FT | KFC Uerdingen | 1-2 (0-1) | Sporting Charleroi | ||
| Pen. | Karlsruher SC | 0-0(0-0) | Sturm Graz* | ||
| FT | Lincoln City | 1-3 (0-2) | Sheffield Wednesday | ||
| FT | Preussen Muenster | 1-3 (0-0) | Heracles | ||
| FT | SC Heerenveen | 1-4 (0-1) | FC Volendam | ||
| Pen. | *MSV Duisburg | 1-1(1-1) | Stoke City | ||
| FT | Augsburg | 1-0 (1-0) | Greuther Fuerth | ||
| FT | BW Linz | 0-3 (0-0) | Union Berlin | ||
| FT | Mattersburg | 1-1 (1-0) | Holstein Kiel | ||
| FT | St. Patrick's Athletic | 0-4 (0-2) | Chelsea | ||
| FT | Bayer Leverkusen | 0-1 (0-1) | Fortuna Sittard | ||
| FT | Hertha Berlin | 1-0 (1-0) | Sturm Graz | ||
| FT | Hoffenheim | 3-0 (1-0) | Eintracht Braunschweig | ||
| FT | LASK | 1-1 (0-1) | FC Heidenheim | ||
| FT | VFL Wolfsburg | 2-2 (0-1) | VVV-Venlo | ||
| FT | AFC Fylde | 0-4 (0-3) | Preston North End | ||
| FT | Bedford Town | 1-2 (0-0) | Luton Town | ||
| FT | Borussia Moenchengladbach | 1-0 (1-0) | 1860 Munich | ||
| FT | Celtic | 0-0 (0-0) | Rennes | ||
| FT | Crawley Town | 2-3 (0-2) | Swansea City | ||
| FT | Hamburger SV | 0-1 (0-1) | Huddersfield Town | ||
| Pen. | Karlsruher SC | 1-1(1-1) | Hertha Berlin* | ||
| FT | Kortrijk | 1-2 (0-0) | NAC Breda | ||
| FT | Sion | 0-0 (0-0) | Xamax | ||
| FT | Stocksbridge Park Steels | 0-5 (0-1) | Sheffield Wednesday | ||
| FT | Welling United | 0-2 (0-2) | Charlton Athletic | ||
| FT | Lyon | 1-2 (0-2) | Servette | ||
| FT | AZ Alkmaar | 0-3 (0-1) | Telstar | ||
| FT | Angers | 3-1 (1-0) | Les Herbiers | ||
| FT | Dijon | 2-1 (1-1) | Auxerre | ||
| FT | Royal Antwerp | 0-0 (0-0) | Valenciennes | ||
| FT | SKN St. Poelten | 3-0 (1-0) | Znojmo | ||
| FT | SV Gaflenz | 0-5 (0-3) | Austria Wien | ||
| FT | Wolfsberger AC | 3-1 (3-0) | Bordeaux | ||
| FT | Bayer Leverkusen | 3-4 (3-2) | Eupen | ||
| FT | Nice | 1-3 (1-1) | Thun | ||
| FT | Offenburger FV | 1-6 (1-3) | Freiburg | ||
| FT | SV Gonsenheim | 0-8 (0-3) | Mainz 05 | ||
| FT | Naples | 1-2 (1-1) | Benevento | ||
| FT | Standard Liege | 0-2 (0-1) | Strasbourg | ||
| FT | Augsburg | 1-0 (1-0) | Borussia Moenchengladbach | ||
| FT | Boluspor | 0-2 (0-1) | Fenerbahce | ||
| FT | Lausanne | 2-1 (0-0) | Monaco | ||
| FT | Lille | 1-1 (1-0) | Reims | ||
| FT | Red Bull Salzbourg | 4-0 (1-0) | Vorwaerts Steyr | ||
| FT | Slovan Bratislava | 4-0 (1-0) | Hartberg | ||
| FT | St-Etienne | 1-1 (1-0) | Clermont Foot | ||
| FT | St.Truiden | 4-2 (3-1) | La Gantoise | ||
| FT | Cercle Bruges | 1-1 (0-0) | Lens | ||
| FT | Lagun Onak | 0-5 (0-3) | Real Sociedad | ||
| FT | Lokeren | 2-2 (2-1) | Zulte Waregem | ||
| FT | Oostende | 0-4 (0-1) | Royal Excel Mouscron | ||
| FT | SC Heerenveen | 2-2 (1-1) | KV Mechelen | ||
| FT | Saint-Gall | 2-2 (1-2) | Sporting CP | ||
| FT | Santa Clara | 2-2 (1-0) | Sporting Covilha | ||
| FT | Villarreal | 3-0 (2-0) | West Bromwich Albion | ||
| Pen. | *Vitoria de Setubal | 2-2(2-2) | Birmingham City | ||
| FT | Atromitos | 0-3 (0-1) | Nottingham | ||
| FT | Portimonense | 0-1 (0-0) | Braga | ||
| FT | FC Bâle | 2-3 (2-2) | VfB Stuttgart | ||
| FT | FC Séville | 2-1 (0-0) | Reading | ||
| FT | Academica | 0-8 (0-3) | Benfica | ||
| FT | San Antonio FC | 0-1 (0-0) | Cardiff City |
| FT | Deportivo Santani | 0-2 (0-1) | Cerro Porteno | ||
| FT | Sol de America | 2-1 (2-1) | Nacional |
| FT | Fortaleza | 2-0 (1-0) | Avai FC | ||
| FT | Gremio | 2-1 (0-1) | Vasco da Gama | ||
| FT | Bahia | 0-1 (0-0) | Santos FC | ||
| FT | Sao Paulo | 1-1 (1-0) | Palmeiras |
| FT | Sligo Rovers | 0-0 (0-0) | Waterford FC |
| FT | Rosenborg | 5-1 (2-1) | Viking | ||
| FT | Bodoe/Glimt | 5-1 (1-0) | Ranheim |
| FT | Ural | 3-2 (1-0) | FC Ufa | ||
| FT | Spartak Moscow | 1-0 (0-0) | PFC Sochi | ||
| FT | FC Rostov | 2-1 (2-0) | FC Orenburg |
| FT | Cobh Ramblers | 2-1 (1-0) | Athlone Town | ||
| FT | Longford Town | 2-1 (1-1) | Drogheda United |
| FT | Tabor | 0-2 (0-2) | Aluminij | ||
| FT | Maribor | 1-2 (0-1) | ND Triglav |
| FT | Astra Giurgiu | 2-2 (1-2) | Botosani | ||
| FT | CFR 1907 Cluj | 1-1 (1-0) | CSM Politehnica Iasi |
| FT | Ludogorets Razgrad | 2-0 (1-0) | FC Tsarsko Selo Sofia 2015 |
| FT | FC Torpedo Minsk | 1-2 (0-2) | Gomel | ||
| FT | Neman Grodno | 0-0 (0-0) | FK Slutsk | ||
| FT | BATE Borisov | 4-1 (2-0) | Torpedo Zhodino |
| FT | Banik Ostrava | 1-2 (1-0) | Slovan Liberec | ||
| FT | Pribram | 1-1 (1-0) | Teplice | ||
| FT | Viktoria Plzen | 3-1 (1-1) | Sigma Olomouc |
| FT | IBV Vestmannaeyjar | 1-2 (0-1) | FH Hafnarfjordur |
| FT | AIK | 3-0 (2-0) | Elfsborg | ||
| FT | Falkenbergs FF | 1-1 (0-0) | IFK Göteborg | ||
| FT | AFC Eskilstuna | 3-1 (2-0) | Kalmar FF |
| FT | Inde | 2-5 (0-3) | Corée du Nord |
| FT | East Kilbride | 0-1 (0-1) | Albion Rovers |
| FT | Berwick Rangers | 0-7 (0-5) | Ayr United | ||
| Pen. | Falkirk | 1-1(1-1) | Livingston* |
| Pen. | Hamilton Academical | 0-0(0-0) | Queen's Park* | ||
| FT | Partick Thistle | 1-0 (0-0) | Airdrieonians |
| FT | Peterhead | 2-1 (2-1) | Cove Rangers | ||
| FT | Raith Rovers | 0-3 (0-2) | Dundee FC |
| FT | Annan Athletic | 0-1 (0-0) | Dumbarton | ||
| FT | Queen of the South | 0-3 (0-0) | Motherwell |
| FT | Forfar Athletic | 3-0 (2-0) | Brechin City | ||
| FT | Ross County | 4-1 (2-0) | Montrose |
| FT | Cowdenbeath | 2-0 (2-0) | East Fife |
| FT | Arbroath | 2-1 (1-1) | Elgin City | ||
| Pen. | Stirling Albion | 1-1(1-1) | Hibernian* |
| FT | Honka | 3-0 (1-0) | HIFK | ||
| FT | SJK | 1-0 (0-0) | VPS |
| FT | Beijing Renhe | 0-2 (0-1) | Wuhan Yangtze River | ||
| FT | Jiangsu FC | 0-3 (0-2) | Shanghai Port | ||
| FT | Tianjin Tianhai | 2-2 (1-1) | Shenzhen FC |
| FT | Dingnan United | 1-1 (1-1) | Zhejiang Professional | ||
| FT | Qingdao FC | 0-0 (0-0) | Shaanxi Changan |
| FT | Matsumoto Yamaga | 0-1 (0-0) | Jubilo Iwata | ||
| FT | Cerezo Osaka | 3-0 (1-0) | Nagoya Grampus | ||
| FT | Gamba Osaka | 1-0 (0-0) | Shimizu S-Pulse | ||
| FT | Oita Trinita | 2-1 (1-1) | Hokkaido Consadole Sapporo | ||
| FT | Vegalta Sendai | 0-4 (0-2) | Kashima Antlers | ||
| FT | Yokohama F.Marinos | 3-1 (1-0) | Urawa Red Diamonds | ||
| FT | Sagan Tosu | 0-2 (0-0) | Sanfrecce Hiroshima |
| FT | FC Anyang | 4-1 (1-0) | Chungnam Asan FC | ||
| FT | Suwon FC | 0-1 (0-0) | Busan I'Park |
| FT | Incheon United | 0-2 (0-1) | FC Seoul | ||
| FT | Jeju SK | 1-1 (1-1) | Pohang Steelers |
