| Pen. | Toronto FC | 0-0(0-0) | Seattle Sounders FC* |
| FT | Rubio Nu | 0-1 (0-1) | Libertad | ||
| FT | Club River Plate | 2-4 (2-1) | Sol de America |
| FT | Sarmiento | 2-0 (2-0) | Tigre | ||
| FT | Temperley | 1-0 (0-0) | Godoy Cruz | ||
| FT | San Lorenzo | 3-2 (1-0) | Union | ||
| FT | Talleres | 1-1 (1-0) | Newell's Old Boys | ||
| FT | Velez Sarsfield | 2-0 (0-0) | Atletico Rafaela | ||
| FT | Gimnasia LP | 1-1 (0-0) | Belgrano | ||
| FT | Racing Club | 0-2 (0-1) | Olimpo |
| FT | Universidad de Chile | 2-2 (1-1) | Huachipato | ||
| FT | Everton CD | 0-3 (0-2) | Antofagasta |
| FT | Barcelona SC | 3-3 (3-0) | Aucas | ||
| FT | Delfin | 4-3 (2-3) | Emelec | ||
| FT | Deportivo Cuenca | 1-1 (1-1) | El Nacional | ||
| FT | Independiente del Valle | 3-2 (1-1) | Guayaquil City | ||
| FT | LDU de Quito | 1-2 (0-1) | Mushuc Runa | ||
| FT | Universidad Catolica | 2-2 (2-1) | Fuerza Amarilla SC |
| FT | Cova da Piedade SAD | 1-0 (1-0) | Maritimo | ||
| FT | Chaves | 2-1 (1-1) | Moreirense | ||
| FT | Boavista | 1-2 (1-1) | Vitoria de Guimaraes |
| FT | Crotone | 2-1 (1-0) | Pescara | ||
| FT | Sampdoria | 1-2 (0-2) | Lazio |
| FT | Osasuna | 0-3 (0-0) | Barcelona | ||
| FT | Real Sociedad | 3-2 (2-1) | Valencia | ||
| FT | Las Palmas | 1-1 (1-0) | Leganes | ||
| FT | Real Madrid | 3-2 (0-0) | Deportivo La Coruna |
| FT | NEC Nijmegen | 3-0 (3-0) | ADO La Haye | ||
| FT | PSV Eindhoven | 1-0 (0-0) | Go Ahead Eagles | ||
| FT | SC Heerenveen | 2-1 (0-1) | Excelsior | ||
| FT | PEC Zwolle | 0-0 (0-0) | Willem II |
| FT | Cercle Bruges | 0-1 (0-0) | Lierse | ||
| FT | OH Leuven | 1-2 (0-1) | Roeselare |
| FT | Gornik Leczna | 3-0 (0-0) | Termalica Nieciecza | ||
| FT | Wisla Plock | 4-3 (2-2) | Ruch Chorzow | ||
| FT | Wisla Krakow | 1-1 (1-0) | Cracovia |
| FT | Eupen | 2-2 (1-1) | Sporting Charleroi | ||
| FT | Kortrijk | 0-1 (0-1) | St.Truiden | ||
| FT | Royal Excel Mouscron | 1-4 (1-2) | KV Mechelen |
| FT | Gimnastic | 0-1 (0-0) | Rayo Vallecano | ||
| FT | Elche | 2-2 (0-2) | Getafe | ||
| FT | SD Huesca | 5-2 (2-1) | UCAM Murcia | ||
| FT | Levante | 1-0 (0-0) | Tenerife |
| FT | Academico Viseu | 1-0 (1-0) | AD Fafe | ||
| FT | Aves | 3-1 (2-0) | Uniao da Madeira | ||
| FT | Braga B | 2-0 (1-0) | Vitoria de Guimaraes B | ||
| FT | Freamunde | 1-1 (1-0) | Olhanense | ||
| FT | Gil Vicente | 0-0 (0-0) | Sporting Covilha | ||
| FT | Sporting CP B | 1-2 (0-1) | FC Porto B | ||
| FT | Academica | 2-1 (1-0) | Benfica B | ||
| FT | Varzim | 2-1 (1-1) | Cova da Piedade | ||
| FT | Santa Clara | 2-1 (0-0) | Penafiel |
| FT | FC Vaduz | 1-1 (0-0) | Lausanne | ||
| FT | FC Bâle | 1-0 (0-0) | Saint-Gall |
| FT | Dijon | 1-2 (0-1) | Marseille | ||
| FT | Bordeaux | 0-4 (0-2) | Monaco | ||
| FT | Lille | 2-1 (2-0) | Montpellier | ||
| FT | Nancy | 2-0 (1-0) | Angers | ||
| FT | SC Bastia | 2-0 (1-0) | Metz | ||
| FT | Toulouse | 3-2 (2-1) | Lorient |
| FT | Hapoel Tel Aviv | 1-1 (0-0) | Bnei Sakhnin | ||
| FT | Hapoel Kfar Saba | 2-2 (1-1) | Hapoel Ironi Kiryat Shmona | ||
| FT | Hapoel Ashkelon | 1-0 (1-0) | Bnei Yehuda Tel Aviv | ||
| FT | Hapoel Raanana | 1-1 (1-0) | Maccabi Haifa |
| FT | Pandurii | 2-5 (2-1) | Gaz Metan Medias | ||
| FT | Botosani | 1-3 (0-2) | CSM Politehnica Iasi | ||
| FT | Dinamo Bucarest | 1-0 (1-0) | Tirgu Mures |
| FT | KAC Kenitra | 1-2 (0-0) | FAR Rabat | ||
| FT | Difaa El Jadida | 2-1 (1-0) | Chabab Atlas Khenifra | ||
| FT | FUS Rabat | 3-2 (3-1) | KACM |
| FT | Asteras Tripolis | 0-0 (0-0) | PAE Veria NFC 2019 | ||
| FT | Xanthi | 1-0 (0-0) | AE Larissa | ||
| FT | AEK Athens | 4-0 (1-0) | Levadiakos |
| FT | Bayern Munich | 5-0 (2-0) | VFL Wolfsburg | ||
| FT | FC Koeln | 1-1 (1-0) | Borussia Dortmund | ||
| FT | Freiburg | 1-0 (0-0) | Darmstadt | ||
| FT | Hamburger SV | 1-0 (0-0) | Augsburg | ||
| FT | Ingolstadt | 1-0 (1-0) | RB Leipzig | ||
| FT | Hertha Berlin | 0-1 (0-1) | Werder Bremen |
| FT | Aston Villa | 1-0 (0-0) | Wigan Athletic | ||
| FT | Barnsley | 2-1 (2-0) | Norwich City | ||
| FT | Brentford | 2-1 (1-1) | Burton Albion | ||
| FT | Huddersfield Town | 2-1 (1-1) | Bristol City | ||
| FT | Ipswich Town | 1-1 (0-1) | Cardiff City | ||
| FT | Newcastle United | 4-0 (2-0) | Birmingham City | ||
| FT | Reading | 2-1 (0-0) | Sheffield Wednesday | ||
| FT | Wolverhampton Wanderers | 4-4 (1-3) | Fulham | ||
| FT | Rotherham United | 1-0 (1-0) | Queens Park Rangers | ||
| FT | Preston North End | 3-2 (2-1) | Blackburn Rovers |
| FT | Watford | 3-2 (1-1) | Everton | ||
| FT | Arsenal | 3-1 (1-1) | Stoke City | ||
| FT | Burnley | 3-2 (2-1) | AFC Bournemouth | ||
| FT | Hull City | 3-3 (1-0) | Crystal Palace | ||
| FT | Swansea City | 3-0 (0-0) | Sunderland | ||
| FT | Leicester City | 4-2 (3-0) | Manchester City |
| FT | Altach | 2-1 (0-0) | Wolfsberger AC | ||
| FT | Mattersburg | 2-0 (1-0) | Admira Wacker |
| FT | TNS | 3-1 (1-1) | Cardiff Met University | ||
| FT | Rhyl | 1-3 (0-1) | Newtown | ||
| FT | Llandudno FC | 2-0 (1-0) | Carmarthen |
| FT | Anagennisi Deryneia | 1-3 (1-2) | AEL Limassol | ||
| FT | Apollon Limassol | 1-1 (1-0) | Nea Salamis | ||
| FT | Ermis Aradippou | 2-2 (0-1) | Omonia Nicosia |
| FT | Diosgyori VTK | 1-0 (1-0) | Gyirmót SE | ||
| FT | Haladas | 1-1 (0-1) | Fehervar FC | ||
| FT | Paksi SE | 1-0 (1-0) | Vasas Budapest | ||
| FT | Ujpest | 2-0 (0-0) | Debreceni VSC | ||
| FT | Budapest Honved | 1-0 (0-0) | Mezokovesd SE | ||
| FT | Ferencvarosi TC | 1-1 (1-0) | MTK Budapest |
| FT | Borac Cacak | 1-0 (1-0) | FK Radnik Surdulica | ||
| FT | FK Metalac | 0-2 (0-1) | Vozdovac | ||
| FT | FK Spartak Subotica | 0-0 (0-0) | Backa Backa Palanka | ||
| FT | Napredak | 0-0 (0-0) | Mladost Lucani | ||
| FT | Rad Beograd | 2-0 (2-0) | Novi Pazar | ||
| FT | FK Crvena Zvezda | 2-1 (2-1) | Radnicki Nis |
| FT | Al Fateh FC | 2-4 (0-2) | Al Khaleej | ||
| FT | Al-Faisaly | 2-4 (1-2) | Al Ittihad |
| FT | Çaykur Rizespor | 0-1 (0-1) | Kasimpasa | ||
| FT | Besiktas | 2-1 (0-0) | Bursaspor | ||
| FT | Genclerbirligi | 0-0 (0-0) | Istanbul Basaksehir |
| FT | Zeleziarne Podbrezova | 1-1 (1-0) | Tatran Presov | ||
| FT | DAC 1904 Dunajska Streda | 1-0 (1-0) | Zlate Moravce | ||
| FT | Ruzomberok | 2-1 (1-0) | FK Senica |
| FT | Cibalia | 1-2 (1-0) | Hajduk Split | ||
| FT | NK Istra 1961 | 1-3 (1-0) | Osijek |
| FT | Aluminij | 2-1 (0-0) | NK Celje | ||
| FT | Gorica | 1-1 (0-1) | Radomlje | ||
| FT | Rudar Velenje | 2-2 (2-2) | Koper | ||
| FT | Domzale | 3-2 (2-2) | Maribor |
| FT | Slavia Sofia | 2-0 (1-0) | Montana | ||
| FT | Vereya | 0-1 (0-0) | Levski Sofia | ||
| FT | Ludogorets Razgrad | 1-0 (1-0) | Lokomotiv Plovdiv |
| FT | Floriana | 1-1 (1-0) | Tarxien Rainbows | ||
| FT | Gzira United | 3-0 (3-0) | Mosta | ||
| FT | Hibernians | 1-1 (0-0) | Pembroke Athleta F.C. | ||
| FT | Saint Andrews | 3-1 (1-1) | Hamrun Spartans |
| FT | CS Fola Esch | 2-2 (1-1) | F91 Dudelange |
| FT | DRB Tadjenanet | 1-1 (1-1) | MC Oran | ||
| FT | Olympique de Medea | 1-1 (1-1) | MC Alger | ||
| FT | CS Constantine | 1-2 (0-2) | NA Hussein Dey | ||
| FT | USM Bel Abbes | 2-0 (0-0) | JS Kabylie |
| FT | Ards | 0-2 (0-2) | Linfield | ||
| FT | Ballinamallard United | 0-1 (0-1) | Crusaders | ||
| FT | Cliftonville | 1-0 (1-0) | Portadown | ||
| FT | Dungannon Swifts | 3-1 (1-0) | Carrick Rangers | ||
| FT | Glenavon | 1-0 (0-0) | Coleraine | ||
| FT | Glentoran | 2-3 (2-0) | Ballymena United |
| FT | Aberdeen | 0-0 (0-0) | St. Johnstone | ||
| FT | Dundee FC | 0-0 (0-0) | Ross County | ||
| FT | Inverness CT | 1-1 (0-1) | Hamilton Academical | ||
| FT | Motherwell | 0-0 (0-0) | Kilmarnock | ||
| FT | Rangers | 2-0 (1-0) | Hearts |
| FT | Lyngby | 1-1 (1-1) | Silkeborg |
| FT | Cosmos | 5-1 (0-0) | San Giovanni | ||
| FT | FC Fiorentino | 2-2 (0-0) | Folgore | ||
| FT | Faetano | 0-3 (0-0) | Domagnano | ||
| FT | Virtus Acquaviva | 2-1 (0-0) | S.S. Murata |
| FT | AC Carpi | 1-1 (0-1) | Ternana | ||
| FT | Ascoli Calcio 1898 FC | 2-2 (0-0) | Latina | ||
| FT | Avellino | 1-1 (1-0) | Benevento | ||
| FT | Cesena | 3-0 (0-0) | Cittadella | ||
| FT | Frosinone | 1-3 (1-1) | Salernitana | ||
| FT | Perugia | 1-0 (0-0) | Pro Vercelli | ||
| FT | SPAL | 2-1 (1-1) | Spezia | ||
| FT | Vicenza | 1-0 (0-0) | Hellas Verona | ||
| FT | Virtus Entella | 2-2 (0-1) | Trapani |
| FT | Strasbourg | 3-1 (2-0) | Lens |
| FT | Volyn | 0-1 (0-0) | Vorskla |
| FT | Kaiserslautern | 0-0 (0-0) | Erzgebirge Aue | ||
| FT | VFL Bochum | 1-0 (0-0) | 1860 Munich |
| FT | Wellington Phoenix | 3-0 (1-0) | Central Coast Mariners | ||
| FT | Western Sydney Wanderers FC | 0-3 (0-1) | Melbourne Victory | ||
| FT | Perth Glory | 1-2 (1-2) | Newcastle Jets |
| FT | Dinamo Batumi | 1-0 (1-0) | Dinamo Tbilisi |
